Zobrazeno 1 - 7
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pro vyhledávání: '"Michael Wortzman"'
Publikováno v:
Vaccine. 39(25)
Background In 2017, the two-dose recombinant zoster vaccine (RZV) was authorized for use in Canada for the prevention of herpes zoster (HZ) in adults ≥ 50 years of age (YOA), which is administered 2–6 months apart. The National Advisory Committee
Publikováno v:
The Journal of Immunology. 194:128.3-128.3
CD4 T cells are critical for control of persistent infections; however, the key signals that regulate CD4 T help during infection remain incompletely defined. Here we show that during lymphocytic choriomeningitis virus (LCMV) clone 13 infection, gluc
Publikováno v:
The Journal of Immunology. 192:191.1-191.1
During persistent infection, the immune system must be tightly regulated to balance immune control against pathology. The glucocorticoid-induced TNFR (GITR) is an important co-stimulatory molecule that plays a critical CD4 T cell-intrinsic role in th
Publikováno v:
The Journal of Immunology. 192:72.1-72.1
Influenza virus induces an acute respiratory infection responsible for up to 500,000 annual deaths, primarily in older persons. CD8+ T cells against conserved influenza proteins confer heterotypic protection, potentially providing a “universal vacc
Publikováno v:
The Journal of Immunology. 190:113.8-113.8
The immune system must be tightly balanced to control infection while avoiding immune pathology. We investigated the role of the glucocorticoid-induced tumour necrosis factor receptor (GITR) during infection of mice with persistent lymphocytic chorio
Autor:
Gloria Hoi Ying Lin, Laura Snell, Michael Wortzman, Mariana Vidric, Charles Surh, Tania Watts
Publikováno v:
The Journal of Immunology. 186:46.18-46.18
Following the resolution of an infection, memory lymphocytes can persist for the lifetime of the animal and play a critical role in protection from re-infection. Using mixed BM chimeras, we show that 4-1BB on the T cells is required for maximal CD8 m
Autor:
Dennis Ng, Leslie Summers deLuca, Yunfei Gao, Michael Wortzman, Tania Watts, Jennifer Gommerman
Publikováno v:
The Journal of Immunology. 186:100.40-100.40
During an acute infection, dendritic cells (DC) are triggered by pattern recognition receptors (PRR) to produce inflammatory molecules that are important for the expansion and function of CD8+ T lymphocytes in order to clear the infection. In contras