Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Michael Wornow"'
Autor:
Michael Wornow, Yizhe Xu, Rahul Thapa, Birju Patel, Ethan Steinberg, Scott Fleming, Michael A. Pfeffer, Jason Fries, Nigam H. Shah
Publikováno v:
npj Digital Medicine, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract The success of foundation models such as ChatGPT and AlphaFold has spurred significant interest in building similar models for electronic medical records (EMRs) to improve patient care and hospital operations. However, recent hype has obscur
Externí odkaz:
https://doaj.org/article/c0096bc125254d20b763e7c5fa711219
Autor:
Jonathan C. Chen, Jonathan P. Chen, Max W. Shen, Michael Wornow, Minwoo Bae, Wei-Hsi Yeh, Alvin Hsu, David R. Liu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
In vitro library screening is a powerful approach to identify functional biopolymers, but only covers a fraction of possible sequences. Here, the authors use experimental in vitro selection results to train a conditional variational autoencoder machi
Externí odkaz:
https://doaj.org/article/502e0dcaf2ca4731b191cf430212bb7e
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4, p e1009497 (2022)
The pathogenesis of many inflammatory diseases is a coordinated process involving metabolic dysfunctions and immune response-usually modulated by the production of cytokines and associated inflammatory molecules. In this work, we seek to understand h
Externí odkaz:
https://doaj.org/article/631f780dbc624201bf4f9d39b954ac1a
Publikováno v:
Journal of Biomedical Informatics. 139:104319
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f11266440c21badbf4b1c2b8a532cc3
https://doi.org/10.1016/j.jbi.2023.104319
https://doi.org/10.1016/j.jbi.2023.104319
Publikováno v:
PLoS computational biology. 18(4)
The pathogenesis of many inflammatory diseases is a coordinated process involving metabolic dysfunctions and immune response—usually modulated by the production of cytokines and associated inflammatory molecules. In this work, we seek to understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff98d9237d84068c0b9bf4ca802055e0
https://pubmed.ncbi.nlm.nih.gov/35404985
https://pubmed.ncbi.nlm.nih.gov/35404985
Autor:
Paige VonAchen, Mark I. Neuman, Chris A. Rees, Michael C. Monuteaux, Michael Wornow, Jayshree Sarathy, Kenneth A. Michelson
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Clinical Infectious Diseases
Clinical Infectious Diseases
Background Hospital inpatient and intensive care unit (ICU) bed shortfalls may arise due to regional surges in volume. We sought to determine how interregional transfers could alleviate bed shortfalls during a pandemic. Methods We used estimates of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34287c9b79687ed35d755233781b4655
http://europepmc.org/articles/PMC7665371
http://europepmc.org/articles/PMC7665371
Autor:
Jonathan C. Chen, Jonathan M. Levy, Rachel A. Burt, Gregory A. Newby, Olga Shubina-Oleinik, David R. Liu, Bifeng Pan, Jeffrey R. Holt, Michael Wornow, Wei-Hsi Yeh
Publikováno v:
Sci Transl Med
Most genetic diseases arise from recessive point mutations that require correction, rather than disruption, of the pathogenic allele to benefit patients. Base editing has the potential to directly repair point mutations and provide therapeutic restor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5995f41202f51f5730858371e3b394
https://pubmed.ncbi.nlm.nih.gov/32514099
https://pubmed.ncbi.nlm.nih.gov/32514099