Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Michael Wleklinski"'
Autor:
Michael Wleklinski, Paige M. Carpenter, Kevin D. Dykstra, Anthony Donofrio, Timothy Nowak, Shane W. Krska, Ronald D. Ferguson
Publikováno v:
SLAS Technology, Vol 29, Iss 2, Pp 100126- (2024)
High-throughput experimentation (HTE) has become more widely utilized in drug discovery for rapid reaction optimization and generation of large synthetic compound arrays. While this has accelerated medicinal chemistry design, make, test (DMT) iterati
Externí odkaz:
https://doaj.org/article/551f9a876fc040d694b69bd9e46488ad
Publikováno v:
ACS Catalysis. 12:3201-3210
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::170275bdc2c12a6fbd5946ffe8d11567
https://doi.org/10.1021/acscatal.1c05502
https://doi.org/10.1021/acscatal.1c05502
Publikováno v:
The Power of High-Throughput Experimentation: Case Studies from Drug Discovery, Drug Development, and Catalyst Discovery (Volume 2) ISBN: 9780841297555
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01a2675e5ccd188380a98d1d22587ccc
https://doi.org/10.1021/bk-2022-1420.ch003
https://doi.org/10.1021/bk-2022-1420.ch003
Autor:
Xingshuo Chen, Zhenwei Wei, Kai‐Hung Huang, Mycah Uehling, Michael Wleklinski, Shane Krska, Alexey A. Makarov, Timothy Nowak, R. Graham Cooks
Publikováno v:
ChemPlusChem. 87(3)
Palladium-catalyzed Suzuki-Miyaura (SM) coupling is widely utilized in the construction of carbon-carbon bonds. In this study, nanoelectrospray ionization mass spectrometry (nanoESI-MS) is applied to simultaneously monitor precatalysts, catalytic int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ceb456aa4530bc08eedfdfe2e90a92c
https://pubmed.ncbi.nlm.nih.gov/35112808
https://pubmed.ncbi.nlm.nih.gov/35112808
Autor:
Spencer D. Dreher, Michael R. Maser, Klavs F. Jensen, Abigail G. Doyle, Michael Wleklinski, Anton Kast, Steven Kearnes, Connor W. Coley, Joel M. Hawkins
Chemical reaction data in journal articles, patents, and even electronic laboratory notebooks are currently stored in various formats, often unstructured, which presents a significant barrier to downstream applications, including the training of mach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6438fc1ea7b025adab5183dd9c46ccc8
https://resolver.caltech.edu/CaltechAUTHORS:20211122-234818109
https://resolver.caltech.edu/CaltechAUTHORS:20211122-234818109
Autor:
Michael Wleklinski, Bradley P. Loren, Tiago J. P. Sobreira, David H. Thompson, Christina R. Ferreira, Larisa Avramova, R. Graham Cooks, Zinia Jaman
Publikováno v:
Chemical Science. 9:1647-1653
We report the high throughput analysis of reaction mixture arrays using methods and data handling routines that were originally developed for biological tissue imaging. Desorption electrospray ionization (DESI) mass spectrometry (MS) is applied in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bbaa29a06fa3aaf5305c9873e2c1d9a
https://doi.org/10.1039/c7sc04606e
https://doi.org/10.1039/c7sc04606e
Autor:
Marion H. Emmert, Matthieu Jouffroy, David C. Leitch, Alexander Buitrago Santanilla, Gemma Cook, Amanda Dombrowski, Nathan Gesmundo, Dipannita Kalyani, Mycah Uehling, Michael Wleklinski, Nicole C. Goodwin, Katherine Honicker, Jonathan Latham, Katherine M. P. Wheelhouse, Sabine Fenner, Matthew P. Whiting, Chunrui Sun, Ji Qi, Feng Peng, Niki R. Patel, Danielle Schultz, Orion Staples, Jacob S. Mohar, Daniel J. Mindiola, Victoria Dimakos, Stephen G. Newman, Stig D. Friis, Erik Weis, Magnus J. Johansson
'High-throughput experimentation (HTE) is an emerging and powerful approach to problems in organic chemistry and homogeneous catalysis. This book is targeted at both experts and those new to the field who are seeking general perspectives and design p
Autor:
Michael Wleklinski, David H. Thompson, H. Samuel Ewan, R. Graham Cooks, Kiran Iyer, Seok-Hee Hyun
Publikováno v:
Organic Process Research & Development. 21:1566-1570
Electrospray and Leidenfrost droplet accelerated reactions were used as a predictive tool for estimating the outcome of microfluidic synthesis as demonstrated by Wleklinski et al. Rapid analysis by electrospray-mass spectrometry (ESI-MS) also provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fee822e1ea9bc7ea3c755c3522364e04
https://doi.org/10.1021/acs.oprd.7b00218
https://doi.org/10.1021/acs.oprd.7b00218
Publikováno v:
Angewandte Chemie International Edition. 56:9386-9390
Thin film formats are used to study the Claisen-Schmidt base-catalyzed condensation of 6-hydroxy-1-indanone with substituted benzaldehydes and to compare reaction acceleration relative to bulk. Acceleration factors relative exceeded 103 initially and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebb99a57b48486e204a3afb4634d549
https://doi.org/10.1002/anie.201704520
https://doi.org/10.1002/anie.201704520
Autor:
R. Graham Cooks, Caitlin E. Falcone, Zinia Jaman, Andy Koswara, Michael Wleklinski, David H. Thompson
Publikováno v:
The Analyst. 142:2836-2845
Preparative electrospray (ES) exploits the acceleration of reactions in charged microdroplets to perform a small scale chemical synthesis. In combination with on-line mass spectrometric (MS) analysis, it constitutes a rapid screening tool to select r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b2166b284da8b54811924436cca000
https://doi.org/10.1039/c7an00622e
https://doi.org/10.1039/c7an00622e