Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Michael Wittekind"'
Autor:
Samantha Forrest, Sarah Ton, Samantha L. Sholes, Sarah Harrison, Roger D. Plaut, Kathleen Verratti, Michael Wittekind, Elham Ettehadieh, Bryan Necciai, Shanmuga Sozhamannan, Sarah L. Grady
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Bacteriophages such as γ and AP50c have been shown to infect strains of Bacillus anthracis with high specificity, and this feature has been exploited in the development of bacterial detection assays. To better understand the emergence of phage resis
Externí odkaz:
https://doaj.org/article/84dbb5ee88ac41deab93c082a9dfe2dd
Publikováno v:
Journal of Virology
Influenza causes widespread illness in humans and can result in morbidity and death, especially in the very young and elderly populations. Because influenza vaccination can be poorly effective some years, and the immune systems of the most susceptibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f009369f93d0e74f065cf8d2e6b2a2ec
https://doi.org/10.1128/jvi.00052-20
https://doi.org/10.1128/jvi.00052-20
Autor:
Raymond Schuch, Michael Wittekind
Publikováno v:
Current Opinion in Microbiology. 33:18-24
Cell wall hydrolases (CWH) are enzymes that build, remodel and degrade peptidoglycan within bacterial cell walls and serve essential roles in cell-wall metabolism, bacteriophage adsorption and bacteriolysis, environmental niche expansion, as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5651fcb350b89f6d199b9a1fa8e7b7f7
https://doi.org/10.1016/j.mib.2016.05.006
https://doi.org/10.1016/j.mib.2016.05.006
Publikováno v:
Molecular Pharmaceutics. 13:1636-1645
Successful development of monoclonal antibodies (mAbs) for therapeutic applications requires identification of mAbs with favorable biophysical properties (high solubility and low viscosity) in addition to potent bioactivities. Nevertheless, mAbs can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38fcd034c733d309ccc94090b441e9a
https://doi.org/10.1021/acs.molpharmaceut.6b00071
https://doi.org/10.1021/acs.molpharmaceut.6b00071
Autor:
Adam Vigil, Michael Wittekind, Scott Johnson, Lawrence M. Kauvar, Angeles Estelles, Ralph A. Tripp
Publikováno v:
Antimicrobial Agents and Chemotherapy
Although antibodies that effectively neutralize a broad set of influenza viruses exist in the human antibody repertoire, they are rare. We used a single-cell screening technology to identify rare monoclonal antibodies (MAbs) that recognized a broad s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b47c42dc2c9d39e2d85983284efd1d
https://pubmed.ncbi.nlm.nih.gov/29507069
https://pubmed.ncbi.nlm.nih.gov/29507069
Publikováno v:
Antimicrobial agents and chemotherapy. 61(7)
Biofilms pose a unique therapeutic challenge because of the antibiotic tolerance of constituent bacteria. Treatments for biofilm-based infections represent a major unmet medical need, requiring novel agents to eradicate mature biofilms. Our objective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313c9a3d404dcdbc3c95c82ad834c83a
https://pubmed.ncbi.nlm.nih.gov/28461319
https://pubmed.ncbi.nlm.nih.gov/28461319
Autor:
Michael Wittekind, Kannan Gunasekaran, Soo Bin Ng, Carla Forte, Min Shen, Marc W. Retter, Logan Garrett, Teresa L. Born, Kathy Manchulenko, Wei Yan, Anne Woodward, Heather Sweet, Ian Foltz, Martin Pentony
Publikováno v:
Journal of Biological Chemistry. 285:19637-19646
Naturally occurring IgG antibodies are bivalent and monospecific. Bispecific antibodies having binding specificities for two different antigens can be produced using recombinant technologies and are projected to have broad clinical applications. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ace3d28eb6604435f0114db01e110497
https://doi.org/10.1074/jbc.m110.117382
https://doi.org/10.1074/jbc.m110.117382
Autor:
Ronald E. Rose, Michael Wittekind, David R. Langley, Jacques Friborg, Kevin Kish, Qi Guo, Valentina Goldfarb, Herbert E. Klei, Pin-Fang M. Lin, Yaqun Zhang, Steven Sheriff
Publikováno v:
Journal of Virology. 81:9525-9535
Atazanavir, which is marketed as REYATAZ, is the first human immunodeficiency virus type 1 (HIV-1) protease inhibitor approved for once-daily administration. As previously reported, atazanavir offers improved inhibitory profiles against several commo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8c3c24fb58201b14d92ea4dbf9029b
https://doi.org/10.1128/jvi.02503-05
https://doi.org/10.1128/jvi.02503-05
Autor:
Herbert E. Klei, Chieh Ying J. Chang, Kevin Kish, Yaqun Zhang, John A. Newitt, John S. Tokarski, Dianlin Xie, Janet D. Cheng, Robert Borzillerri, Michael Wittekind, Francis Y.F. Lee, Louis J. Lombardo, Susan E. Kiefer
Publikováno v:
Cancer Research. 66:5790-5797
Chronic myeloid leukemia (CML) is caused by the constitutively activated tyrosine kinase breakpoint cluster (BCR)-ABL. Current frontline therapy for CML is imatinib, an inhibitor of BCR-ABL. Although imatinib has a high rate of clinical success in ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922018662cc96b8ff3a78820c26ccac2
https://doi.org/10.1158/0008-5472.can-05-4187
https://doi.org/10.1158/0008-5472.can-05-4187
Autor:
Martin J. Corbett, Daniel M. Camac, Lisa M. Kopcho, Randine Dowling, Paul E. Morin, Vidhyashankar Ramamurthy, Grace Lee, Jeffrey Tredup, Deepa Calambur, Amy L Lasut, Henry George, Subinay Ganguly, Zhihong Lai, Robert A. Copeland, Dharti Kothari, O Harold Ross, Michael Wittekind, Young B. Kim, Barbara Fish, Jovita Marcinkeviciene, Milton C Hillman, Dale Collins, Janet D. Cheng, Manjula Paruchuri, Andrew P. Combs, Mark R. Witmer, Keqiang Shen, Rob King, Joseph Yanchunas, Lorin A. Thompson, Nilsa R. Graciani, Jianhong Ma
Publikováno v:
Archives of Biochemistry and Biophysics. 410:307-316
Amyloid precursor protein (APP) cleaving enzyme (BACE) is the enzyme responsible for β-site cleavage of APP, leading to the formation of the amyloid-β peptide that is thought to be pathogenic in Alzheimer’s disease (AD). Hence, BACE is an attract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea05a173414a33c249027d3b4e45708e
https://doi.org/10.1016/s0003-9861(02)00690-2
https://doi.org/10.1016/s0003-9861(02)00690-2