Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Michael William Wilson"'
Autor:
Jeffrey E. Campbell, Robin Roof, Peter A. Boxer, Johnson Paul D, Ann M. Janssen, Jamie Singer, Jacob Bradley Schwarz, Nicole S. Roush, Leonard T. Meltzer, Chad L. Stoner, Michael William Wilson, Lisa H. Gold, Shelley R. Graham, Susan Hurst, Ti-Zhi Su, Leonard W. Cooke
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2409-2412
The synthesis and SAR of tolylamines with 5-HT6 receptor antagonist activity is presented. The amine, core aromatic, peripheral aromatic, and ether linker moieties of HTS hit 1 were modulated and the effect on potency at 5-HT6 examined. Tolylpiperidi
Autor:
Xinmin Gan, Laurence Philippe, Brian Sanchez, Karen M. Yates, Ziqiang Wang, Arun K. Agrawal, Pil H. Lee, Cho Ming Loi, Zhen Lou, Haile Tecle, Jo Ann Dumin, Sheila Guppy, Frank Riley, Joan K. Brieland, Christopher James Deur, Sally Przybranowski, Brian Samas, Amy Mae Bunker, Mark Morris, Michael William Wilson, John Richard Booth, Joseph A. Cornicelli, Susan E. Bove, Cleo J. C. Connolly, Gregg Kamilar, Kenneth S. Kilgore, Barry C. Finzel, Heidi Baum, Kathryn A. Welch
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4599-4603
It has been hypothesized that peripherally restricted NMDA receptor antagonists may be effective analgesics for osteoarthritis pain. A class of novel quinoxalinedione atropisomers, first discovered for an NMDA receptor antagonist program for the trea
Autor:
C. J. Blankley, B.R. Krause, Patrick Michael O'brien, Michael William Wilson, K. L. Hamelehle, R. L. Stanfield, D. R. Sliskovic, Bruce David Roth
Publikováno v:
Journal of Medicinal Chemistry. 37:1810-1822
A series of disubstituted ureas containing amide or amine groups was prepared and evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyl transferase in vitro and to lower plasma total cholesterol in a variety of cholesterol-fed rat models
Autor:
Michael William Wilson, Milton L. Hoefle, D. R. Sliskovic, Roger S. Newton, Bruce D. Roth, Charlotte D. Stratton, Daniel F. Ortwine
Publikováno v:
Journal of Medicinal Chemistry. 33:21-31
A novel series of trans-6-(2-pyrrol-1-ylethyl)-4-hydroxypyran-2-ones and their dihydroxy acid derivatives were prepared and evaluated for their ability to inhibit the enzyme HMG-CoA reductase in vitro. A systematic study of substitution at the 2- and