Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Michael Wigerius"'
Autor:
Dylan P. Quinn, Annette Kolar, Sydney A. Harris, Michael Wigerius, James P. Fawcett, Stefan R. Krueger
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Neuronal activity is thought to drive the remodeling of circuits in the mammalian cerebral cortex. However, its precise function in the underlying formation and elimination of glutamatergic synapses has remained controversial. To clarify the role of
Externí odkaz:
https://doaj.org/article/b3bce73cedbc45f99c1290ce9caf1939
Publikováno v:
Biomolecules, Vol 10, Iss 5, p 749 (2020)
Strategies to create functional organs and tissues is of great interest for use in regenerative medicine in order to repair or replace the lost tissues due to injury, disease, as well as aging. Several new treatment options, including stem cell treat
Externí odkaz:
https://doaj.org/article/097231fb1617450bb8171b9807c1e36b
Autor:
Antonios M. Diab, Michael Wigerius, Dylan P. Quinn, Jiansong Qi, Ibrahim Shahin, Julia Paffile, Kavita Krueger, Barbara Karten, Stefan R. Krueger, James P. Fawcett
Publikováno v:
The Journal of Neuroscience. 43:885-901
Memory formation and maintenance is a dynamic process involving the modulation of the actin cytoskeleton at synapses. Understanding the signaling pathways that contribute to actin modulation is important for our understanding of synapse formation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a6e8e95581f664a44d8c457563188d
https://doi.org/10.1523/jneurosci.0495-21.2022
https://doi.org/10.1523/jneurosci.0495-21.2022
Publikováno v:
Science Signaling. 13
Angiomotins are a family of molecular scaffolding proteins that function to organize contact points (called tight junctions in vertebrates) between adjacent cells. Some angiomotin isoforms bind to the actin cytoskeleton and are part of signaling path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc3c1b0f11a4e388ee348bbbcaf15f8
https://doi.org/10.1126/scisignal.abc0635
https://doi.org/10.1126/scisignal.abc0635
Publikováno v:
Biomolecules
Biomolecules, Vol 10, Iss 749, p 749 (2020)
Biomolecules, Vol 10, Iss 749, p 749 (2020)
Strategies to create functional organs and tissues is of great interest for use in regenerative medicine in order to repair or replace the lost tissues due to injury, disease, as well as aging. Several new treatment options, including stem cell treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe50245c053e4878ab2ec583abc59c71
https://pubmed.ncbi.nlm.nih.gov/32408488
https://pubmed.ncbi.nlm.nih.gov/32408488
Autor:
Antonios Diab, Jiansong Qi, James P. Fawcett, Leanne Clattenburg, Annette Kolar, Michael Wigerius, Dylan P. Quinn, Stefan R. Krueger
Publikováno v:
The Journal of Cell Biology
Wigerius et al. identify the polarity protein AMOT-130 as vital for dendritic spine morphogenesis. They show that reduced Lats1 kinase activity in the neonatal brain is required for the recruitment of AMOT-130 to postsynaptic compartments to stabiliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9649d0d10fcbebd00692d9ee6c92eb57
http://europepmc.org/articles/PMC5800806
http://europepmc.org/articles/PMC5800806
Autor:
James P. Fawcett, Blair A Williams, Jonathan Trites, Matthew H. Rigby, M. Elise Graham, Faisal Alzahrani, Leanne Clattenburg, Christopher J. Sinal, Robert D. Hart, Michael Wigerius, Martin Bullock, Shanmugam Muruganandan, S. Mark Taylor, Kaitlyn MacIsaac
Publikováno v:
Paediatrics Publications
Journal of Otolaryngology-Head & Neck Surgery
Journal of Otolaryngology-Head & Neck Surgery
Background: HPV infection causes cervical cancer, mediated in part by the degradation of Scribble via the HPV E6 oncoprotein. Recently, Scribble has been shown to be an important regulator of the Hippo signaling cascade. Deregulation of the Hippo pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2c30de02ab5f392bd1bb8ca2e37dc1
https://ir.lib.uwo.ca/context/paedpub/article/2426/viewcontent/s40463_017_0187_1.pdf
https://ir.lib.uwo.ca/context/paedpub/article/2426/viewcontent/s40463_017_0187_1.pdf
Autor:
James P. Fawcett, Rachel N. Gomm-Kolisko, Stefan R. Krueger, Annette Kolar, Michael Wigerius, Hanine Atwi, Dylan P. Quinn
Publikováno v:
Scientific Reports
Neurexins are a diverse family of cell adhesion molecules that localize to presynaptic specializations of CNS neurons. Heterologous expression of neurexins in non-neuronal cells leads to the recruitment of postsynaptic proteins in contacting dendrite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299809833c3be6edd118ed5460070324
https://doi.org/10.1038/srep42920
https://doi.org/10.1038/srep42920
Autor:
Michael Wigerius, Magnus Johansson, Christer Hedström, Annelie Elväng, Karin Ellencrona, Wessam Melik
Publikováno v:
Virus Research. 169:54-62
The flavivirus genus includes important human neurotropic pathogens like Tick-borne encephalitis virus (TBEV) and West-Nile virus (WNV). Flavivirus replication occurs at replication complexes, where the NS5 protein provides both RNA cap methyltransfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30bbfc119b4d44eda5f30d68dbe7c9cc
https://doi.org/10.1016/j.virusres.2012.07.001
https://doi.org/10.1016/j.virusres.2012.07.001
Autor:
James P. Fawcett, Leanne Clattenburg, Jillian L. Rourke, Jan K. Rainey, Jiansong Qi, Christopher J. Sinal, Shanmugam Muruganandan, Michael Wigerius
Deregulation of cellular polarity proteins and their associated complexes leads to changes in cell migration and proliferation. The nitric oxide synthase 1 adaptor protein (NOS1AP) associates with the tumor suppressor protein Scribble to control cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f5893b3888421e2637328c7b9d9837
https://europepmc.org/articles/PMC4456437/
https://europepmc.org/articles/PMC4456437/