Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Michael Wierer"'
Autor:
Elena Ethel Vidal-Calvo, Anne Martin-Salazar, Swati Choudhary, Robert Dagil, Sai Sundar Rajan Raghavan, Lara Duvnjak, Mie Anemone Nordmaj, Thomas Mandel Clausen, Ann Skafte, Jan Oberkofler, Kaituo Wang, Mette Ø Agerbæk, Caroline Løppke, Amalie Mundt Jørgensen, Daria Ropac, Joana Mujollari, Shona Willis, Agnès Garcias López, Rebecca Louise Miller, Richard Torbjörn Gustav Karlsson, Felix Goerdeler, Yen-Hsi Chen, Ana R. Colaço, Yong Wang, Thomas Lavstsen, Agnieszka Martowicz, Irina Nelepcu, Mona Marzban, Htoo Zarni Oo, Maj Sofie Ørum-Madsen, Yuzhuo Wang, Morten A. Nielsen, Henrik Clausen, Michael Wierer, Dominik Wolf, Ismail Gögenur, Thor G. Theander, Nader Al-Nakouzi, Tobias Gustavsson, Mads Daugaard, Ali Salanti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Molecular similarities between embryonic and malignant cells can be exploited to target tumors through specific signatures absent in healthy adult tissues. One such embryonic signature tumors express is oncofetal chondroitin sulfate (ofCS),
Externí odkaz:
https://doaj.org/article/b0285b53e90a45a8a481845883fadcba
Autor:
Jonathan Samuel Achter, Estefania Torres Vega, Andrea Sorrentino, Konstantin Kahnert, Katrine Douglas Galsgaard, Pablo Hernandez-Varas, Michael Wierer, Jens Juul Holst, Jørgen Frank Pind Wojtaszewski, Robert William Mills, Rasmus Kjøbsted, Alicia Lundby
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Background Insulin signaling regulates cardiac substrate utilization and is implicated in physiological adaptations of the heart. Alterations in the signaling response within the heart are believed to contribute to pathological conditions su
Externí odkaz:
https://doaj.org/article/7f7d63dc57134c099c235fc73a14ffc2
Autor:
Catherine Milne, Ralf Wagner, François Cano, Martijn Bruysters, Geneviève Waeterloos, Dieter Pullirsch, Michael Wierer, Laurent Mallet
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-9 (2023)
Abstract Vaccines have been a key tool in stemming the tide of the COVID-19 pandemic. The rapid development of effective vaccines against COVID-19, together with their regulatory approval and wide scale distribution has been achieved in an impressive
Externí odkaz:
https://doaj.org/article/be83019e34f24b46adbe438f6287ce2a
Autor:
Carmen Saenz, Qing Fang, Thiyagarajan Gnanasekaran, Samuel Addison Jack Trammell, Jesse Arnold Buijink, Paola Pisano, Michael Wierer, Frédéric Moens, Bettina Lengger, Asker Brejnrod, Manimozhiyan Arumugam
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT Clostridioides difficile infection (CDI) is a major health concern and one of the leading causes of hospital-acquired diarrhea in many countries. C. difficile infection is challenging to treat as C. difficile is resistant to multiple antibio
Externí odkaz:
https://doaj.org/article/6f829f01dd00429bb49ee1ed4f95b513
Autor:
Karl-Uwe Reusswig, Julia Bittmann, Martina Peritore, Mathilde Courtes, Benjamin Pardo, Michael Wierer, Matthias Mann, Boris Pfander
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Reusswig et al. use engineered systems to force DNA replication in the G1 phase of the cell cycle. This unscheduled G1 replication shows hallmarks of S phase replication, but leads to over-replication and DNA breaks from replication collisions.
Externí odkaz:
https://doaj.org/article/bfee13acd0e941099de2ced3aaee11a4
Autor:
Kai P. Hoefig, Alexander Reim, Christian Gallus, Elaine H. Wong, Gesine Behrens, Christine Conrad, Meng Xu, Lisa Kifinger, Taku Ito-Kureha, Kyra A. Y. Defourny, Arie Geerlof, Josef Mautner, Stefanie M. Hauck, Dirk Baumjohann, Regina Feederle, Matthias Mann, Michael Wierer, Elke Glasmacher, Vigo Heissmeyer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
An extensive RNA binding protein atlas (RBPome) for primary T cells would be a useful resource. Here the authors use two different methods to characterise the mouse and human T cell RBPome and show regulation of Roquin-1/2 dependent and independent p
Externí odkaz:
https://doaj.org/article/79f61fbb2db9463391f56fc5ab732e2e
Autor:
Christopher B. Mulholland, Atsuya Nishiyama, Joel Ryan, Ryohei Nakamura, Merve Yiğit, Ivo M. Glück, Carina Trummer, Weihua Qin, Michael D. Bartoschek, Franziska R. Traube, Edris Parsa, Enes Ugur, Miha Modic, Aishwarya Acharya, Paul Stolz, Christoph Ziegenhain, Michael Wierer, Wolfgang Enard, Thomas Carell, Don C. Lamb, Hiroyuki Takeda, Makoto Nakanishi, Sebastian Bultmann, Heinrich Leonhardt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-24 (2020)
Active and passive demethylation pathways have been implicated in the genome-wide erasure of 5mC accompanying mammalian preimplantation development. Here the authors reveal a recently evolved, mammalian-specific pathway in which global hypomethylatio
Externí odkaz:
https://doaj.org/article/de4c9930854d459f81d5177982c48222
Autor:
Alexander Reim, Roland Ackermann, Jofre Font-Mateu, Robert Kammel, Miguel Beato, Stefan Nolte, Matthias Mann, Christoph Russmann, Michael Wierer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Cross-linking mass spectrometry (MS) is an important tool in structural biology, but its application to protein-DNA complexes has been hampered by low cross-linking efficiency. Here, the authors develop a femtosecond UV-laser induced cross-linking MS
Externí odkaz:
https://doaj.org/article/92fea555226e4693b60d8da44e4a57ca
Autor:
Carolin Hoefner, Tenna Holgersen Bryde, Celina Pihl, Sylvia Naiga Tiedemann, Sophie Emilie Bresson, Hajira Ahmed Hotiana, Muhammad Saad Khilji, Theodore Dos Santos, Michele Puglia, Paola Pisano, Mariola Majewska, Julia Durzynska, Kristian Klindt, Justyna Klusek, Marcelo J. Perone, Robert Bucki, Per Mårten Hägglund, Pontus Emanuel Gourdon, Kamil Gotfryd, Edyta Urbaniak, Malgorzata Borowiak, Michael Wierer, Patrick Edward MacDonald, Thomas Mandrup-Poulsen, Michal Tomasz Marzec
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 152 (2023)
Apart from chaperoning, disulfide bond formation, and downstream processing, the molecular sequence of proinsulin folding is not completely understood. Proinsulin requires proline isomerization for correct folding. Since FK506-binding protein 2 (FKBP
Externí odkaz:
https://doaj.org/article/20ad96ddb7074192b89914e9a51cc41b
Autor:
M. Charlotte Hemmer, Michael Wierer, Kristina Schachtrup, Michael Downes, Norbert Hübner, Ronald M. Evans, N. Henriette Uhlenhaut
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Glucocorticoids (GCs) are widely used anti-inflammatory drugs; however, long-term treatment causes metabolic side effects. Here, the authors show that E47 is a modulator of glucocorticoid receptor activity for a subset of target genes in mouse liver,
Externí odkaz:
https://doaj.org/article/c66a0d65c60642e39dc4efc1ae62484e