Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Michael Wiedmann"'
Autor:
Katrin Bomans, Antje Lang, Veronika Roedl, Lisa Adolf, Kyrillos Kyriosoglou, Katharina Diepold, Gabriele Eberl, Michael Mølhøj, Ulrike Strauss, Christian Schmalz, Rudolf Vogel, Dietmar Reusch, Harald Wegele, Michael Wiedmann, Patrick Bulau
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81639 (2013)
Biotherapeutics are often produced in non-human host cells like Escherichia coli, yeast, and various mammalian cell lines. A major focus of any therapeutic protein purification process is to reduce host cell proteins to an acceptable low level. In th
Externí odkaz:
https://doaj.org/article/23d5cfa594f7468d982b8dc7374de449
Autor:
Katharina Diepold, Katrin Bomans, Michael Wiedmann, Boris Zimmermann, Andreas Petzold, Tilman Schlothauer, Robert Mueller, Bernd Moritz, Jan Olaf Stracke, Michael Mølhøj, Dietmar Reusch, Patrick Bulau
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30295 (2012)
The degradation of proteins by asparagine deamidation and aspartate isomerization is one of several chemical degradation pathways for recombinant antibodies. In this study, we have identified two solvent accessible degradation sites (light chain aspa
Externí odkaz:
https://doaj.org/article/63d2f5101a07455a8160942e9fc16b2b
Autor:
Sanjay K. Gupta, Tobias Graf, Franziska T. Edelmann, Helen Seelmann, Markus Reintinger, Lars Hillringhaus, Frank Bergmann, Michael Wiedmann, Roberto Falkenstein, Harald Wegele, Inn H. Yuk, Michael Leiss
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 187:120-129
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f14b2ffff50809d2441c373d1bab989
https://doi.org/10.1016/j.ejpb.2023.04.021
https://doi.org/10.1016/j.ejpb.2023.04.021
Publikováno v:
Educational technology research and development. 70:691-712
Educational technologies in mathematics typically focus on fostering either procedural knowledge by means of structured tasks or, less often, conceptual knowledge by means of exploratory tasks. However, both types of knowledge are needed for complete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd9c799c2167a9e957e304ca4af1fc3b
https://doi.org/10.1007/s11423-022-10104-0
https://doi.org/10.1007/s11423-022-10104-0
Autor:
Christina Seisenberger, Tobias Graf, Sarah Sticht, Markus Haindl, Ulrich Mohn, Harald Wegele, Michael Wiedmann, Stefanie Wohlrab
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 120(1)
Host cell proteins (HCPs) are inevitable process-related impurities in biotherapeutics commonly monitored by enzyme-linked immunosorbent assays (ELISAs). Of particular importance for their reliable detection are the anti-HCP polyclonal antibodies (pA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3537e19711f7abf13580d0e158c7b047
https://pubmed.ncbi.nlm.nih.gov/36251621
https://pubmed.ncbi.nlm.nih.gov/36251621
Publikováno v:
The European Physical Journal Special Topics. 230:851-857
Based on a recently developed non-perturbative platform designed to simulate the full quantum dynamics of quantum thermal machines, the situation of a quantum refrigerator operating according to an Otto cycle is studied. The periodic steady-state dyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30c027df291adcea772d8da447a5458f
https://doi.org/10.1140/epjs/s11734-021-00094-0
https://doi.org/10.1140/epjs/s11734-021-00094-0
Autor:
Harald Wegele, Michael Wiedmann, Christina Seisenberger, Tobias Graf, Stefanie Wohlrab, Markus Haindl
Publikováno v:
Biotechnology and Bioengineering. 118:1116-1126
Host cell proteins (HCPs) constitute a major class of process-related impurities, whose substantial clearance must be demonstrated by suitable analytical methods to warrant product quality and reduce potential safety risks for patients. In this regar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1f373e352a2e24a02460a8569ec0bb
https://doi.org/10.1002/bit.27635
https://doi.org/10.1002/bit.27635
Autor:
Christina Seisenberger, Tobias Graf, Markus Haindl, Harald Wegele, Michael Wiedmann, Stefanie Wohlrab
Publikováno v:
Biotechnology Progress. 38
In the control strategy for process related impurities in biopharmaceuticals, the enzyme linked immunosorbent assay (ELISA) is the method of choice for the quantification of host cell proteins (HCPs). Besides two dimensional-western blots (2D-WB), th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a221171c0311f4266cd5126b8d99990f
https://doi.org/10.1002/btpr.3244
https://doi.org/10.1002/btpr.3244
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 118(10)
The performance of immunoassays for the detection and quantification of host-cell proteins (HCPs) in biopharmaceuticals depends on the quality of the critical assay reagents. Not only their preparation, but also a stringent life-cycle management, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299a4003902db2322508200516640217
https://pubmed.ncbi.nlm.nih.gov/34241893
https://pubmed.ncbi.nlm.nih.gov/34241893
Autor:
Ulrich Hagel, Michael Wiedmann
Das Lieferkettensorgfaltspflichtengesetz verlangt von den in seinen Anwendungsbereich fallenden Unternehmen festzulegen, wer für die Überwachung des Risikomanagements zuständig ist. Die Geschäftsleitung erfüllt diese Pflicht durch die Benennung
