Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Michael Weinreich"'
Autor:
Jessica R. Eisenstatt, Lars Boeckmann, Wei-Chun Au, Valerie Garcia, Levi Bursch, Josefina Ocampo, Michael Costanzo, Michael Weinreich, Robert A. Sclafani, Anastasia Baryshnikova, Chad L. Myers, Charles Boone, David J. Clark, Richard Baker, Munira A. Basrai
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 6, Pp 2057-2068 (2020)
The evolutionarily conserved centromeric histone H3 variant (Cse4 in budding yeast, CENP-A in humans) is essential for faithful chromosome segregation. Mislocalization of CENP-A to non-centromeric chromatin contributes to chromosomal instability (CIN
Externí odkaz:
https://doaj.org/article/18406182fbf848b19238234c13a0f3b1
Publikováno v:
Interventional Cardiology: Reviews, Research, Resources, Vol 14, Iss 3, Pp 182-189 (2019)
Rotational atherectomy (RA) is an atheroablative technology that enables percutaneous coronary intervention for complex, calcified coronary lesions. RA works on the principle of ‘differential cutting’ and preferentially ablates hard, inelastic, c
Externí odkaz:
https://doaj.org/article/e86af9ab245549548c18cee2ac1b1eec
Autor:
Nanda Kumar Sasi, Flavie Coquel, Yea-Lih Lin, Jeffrey P MacKeigan, Philippe Pasero, Michael Weinreich
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 10, Pp 985-995 (2018)
Summary: CDC7-DBF4 kinase (DDK) initiates DNA replication in eukaryotes by activating the replicative MCM helicase. DDK has diverse and apparently conflicting roles in the replication checkpoint response in various organisms, but the underlying mecha
Externí odkaz:
https://doaj.org/article/bb1c67a26bea41f6b90ce1548bb39b94
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 5, Pp 439-450 (2017)
DBF4-dependent kinase (DDK) is a two-subunit kinase required for initiating DNA replication at individual origins and is composed of CDC7 kinase and its regulatory subunit DBF4. Both subunits are highly expressed in many diverse tumor cell lines and
Externí odkaz:
https://doaj.org/article/7cb955dcc1b5490eb08c9672b832c9d0
Autor:
Timothy A Hoggard, FuJung Chang, Kelsey Rae Perry, Sandya Subramanian, Jessica Kenworthy, Julie Chueng, Erika Shor, Edel M Hyland, Jef D Boeke, Michael Weinreich, Catherine A Fox
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007418 (2018)
Most active DNA replication origins are found within euchromatin, while origins within heterochromatin are often inactive or inhibited. In yeast, origin activity within heterochromatin is negatively controlled by the histone H4K16 deacetylase, Sir2,
Externí odkaz:
https://doaj.org/article/8d599bf378214fdca25d45a07be1710b
Autor:
Pedro A. Villablanca, Wilman Olmedo, Michael Weinreich, Tanush Gupta, Divyanshu Mohananey, Felipe N. Albuquerque, Ibrahim Kassas, David Briceño, Cristina Sanina, Thomas A. Brevik, Emily Ong, Harish Ramakrishna, Michael Attubato, Mark Menegus, Jose Wiley, Ankur Kalra
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 8 (2018)
BackgroundStudies have shown that chronic total occlusion (CTO) in a noninfarct‐related artery in patients with ST‐segment–elevation myocardial infarction is linked to increased mortality. It remains unclear whether staged revascularization of
Externí odkaz:
https://doaj.org/article/d3de2721cf944cae94fb059555ce02b6
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 9, Pp 920-931 (2008)
Cdc7 is a conserved serine/threonine kinase essential for the initiation of DNA replication, likely by activating the MCM DNA helicase at the G1- to S-phase transition. Cdc7 kinase activity requires association with its regulatory subunit Dbf4/activa
Externí odkaz:
https://doaj.org/article/742f7d10e357430ba3f2a9c35ac2c2ee
Autor:
FuJung Chang, Alberto Riera, Cecile Evrin, Jingchuan Sun, Huilin Li, Christian Speck, Michael Weinreich
Publikováno v:
eLife, Vol 4 (2015)
To initiate DNA replication, cells first load an MCM helicase double hexamer at origins in a reaction requiring ORC, Cdc6, and Cdt1, also called pre-replicative complex (pre-RC) assembly. The essential mechanistic role of Cdc6 ATP hydrolysis in this
Externí odkaz:
https://doaj.org/article/d9e1d9e63c5b46faace2699f92228e7e
Autor:
Nanda Kumar Sasi, Kanchan Tiwari, Fen-Fen Soon, Dorine Bonte, Tong Wang, Karsten Melcher, H Eric Xu, Michael Weinreich
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113300 (2014)
Cdc7-Dbf4 kinase or DDK (Dbf4-dependent kinase) is required to initiate DNA replication by phosphorylating and activating the replicative Mcm2-7 DNA helicase. DDK is overexpressed in many tumor cells and is an emerging chemotherapeutic target since D
Externí odkaz:
https://doaj.org/article/5b2e67871d134f41aeaf944fb28e5ee8
Autor:
Erika Shor, Christopher L Warren, Joshua Tietjen, Zhonggang Hou, Ulrika Müller, Ilaria Alborelli, Florence H Gohard, Adrian I Yemm, Lev Borisov, James R Broach, Michael Weinreich, Conrad A Nieduszynski, Aseem Z Ansari, Catherine A Fox
Publikováno v:
PLoS Genetics, Vol 5, Iss 12, p e1000755 (2009)
The origin recognition complex (ORC) marks chromosomal sites as replication origins and is essential for replication initiation. In yeast, ORC also binds to DNA elements called silencers, where its primary function is to recruit silent information re
Externí odkaz:
https://doaj.org/article/6789becc7c98478a9587243c67348fd3