Výsledky vyhledávání - "Michael W. Scherz"

Akademický článek

Pharmacological Profile of MP-101, a Novel Non-racemic Mixture of R- and S-dimiracetam with Increased Potency in Rat Models of Cognition, Depression and Neuropathic Pain

Autor: Tiziana Bonifacino, Laura Micheli, Carola Torazza, Carla Ghelardini, Carlo Farina, Giambattista Bonanno, Marco Milanese, Lorenzo Di Cesare Mannelli, Michael W. Scherz

Publikováno v: Cells, Vol 11, Iss 24, p 4027 (2022)

The racemic mixture dimiracetam negatively modulates NMDA-induced glutamate release in rat spinal cord synaptosomal preparations and is orally effective in models of neuropathic pain. In this study, we compared the effects of dimiracetam, its R- or S

Externí odkaz: https://doaj.org/article/0de4dabf2e514ac0b215c48ef46c7c05

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Three different up-titration regimens of ponesimod, an S1P1 receptor modulator, in healthy subjects

Autor: Michael W, Scherz, Patrick, Brossard, Daniele, D'Ambrosio, Murat, Ipek, Jasper, Dingemanse

Publikováno v: Journal of clinical pharmacology. 55(6)

Ponesimod is a selective S1P1 receptor modulator, and induces dose-dependent reduction of circulating lymphocytes upon oral dosing. Previous studies showed that single doses up to 75 mg or multiple doses up to 40 mg once daily are well tolerated, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b953b52d51ec985837f683a9fabfbd9f
https://pubmed.ncbi.nlm.nih.gov/25612299

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Synthesis and structure-activity relationships of N,N'-di-o-tolylguanidine analogues, high-affinity ligands for the haloperidol-sensitive sigma receptor

Autor: Fialeix M, J B Fischer, Eckard Weber, A C Server, John F. W. Keana, Sonders Ms, Tester Bc, Michael W. Scherz, S. T. Wong, N. L. Reddy

Publikováno v: Journal of medicinal chemistry. 33(9)

With an eye toward the development of novel atypical antipsychotic agents, we have studied the structure-affinity relationships of N,N'-di-o-tolylguanidine (DTG, 3) and its congeners at the haloperidol-sensitive sigma receptor. A number of DTG analog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71590327aea12951767523c51b7d619
https://pubmed.ncbi.nlm.nih.gov/1975275

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New Cyclooxygenase-2/5-Lipoxygenase Inhibitors. 2. 7-tert-Butyl-2,3-dihydro-3,3-dimethylbenzofuran Derivatives as Gastrointestinal Safe Antiinflammatory and Analgesic Agents: Variations of the Dihydrobenzofuran Ring

Autor: John M. Janusz, Patricia A. Young, Michael W. Scherz, Kevin Enzweiler, Laurence I. Wu, Lixian Gan, Stanislaw Pikul, Kelly L. McDow-Dunham, Carl R. Johnson, C. B. Senanayake, David E. Kellstein, Shelley A. Green, Jennifer L. Tulich, Theresa Rosario-Jansen, I. Jack Magrisso, Kenneth R. Wehmeyer, Deborah L. Kuhlenbeck, Thomas H. Eichhold, Roy L. M. Dobson

Publikováno v: Journal of Medicinal Chemistry. 41:3102-3102

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd4682d0f1c1c9b7f2e821d4bd9de5b1
https://doi.org/10.1021/jm980341b

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Synthesis and characterization of an affinity label for brain receptors to psychotomimetic benzomorphans: differentiation of σ-type and phencyclidine receptors

Autor: Joseph S. Esherick, Mark S. Sonders, Joanne T. Adams, Barbara C. Tester, Michael W. Scherz, Peter M. Teal, Eckard Weber, John F. W. Keana

Publikováno v: European Journal of Pharmacology. 142:61-71

Brain sigma-type receptors and phencyclidine receptors are thought to mediate the psychotomimetic effects of benzomorphans and phencyclidine in humans. Recently, we reported the characterization of a selective sigma receptor ligand, 1,3-di-o-tolyl-gu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e559e0fa50fa0c12fea155b07aa3fd
https://doi.org/10.1016/0014-2999(87)90654-6

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Synthesis and characterization of a radiolabelled derivative of the phencyclidine/N-methyl-D-aspartate receptor ligand (+) MK-801 with high specific radioactivity

Autor: Eckard Weber, Mark S. Sonders, John F. W. Keana, Merrit L. Quarum, Michael W. Scherz

Publikováno v: Life sciences. 43(12)

A [3H]-labelled derivative of the drug (+)MK-801 with a high specific radioactivity was synthesized by first preparing a tribromo derivative of (+)MK-801 followed by catalytic reduction in the presence of [3H]-gas and subsequent purification of the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873b1fe4602abf9d4369cfab52b804d4
https://pubmed.ncbi.nlm.nih.gov/2845205

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Synthesis and characterization of a series of diarylguanidines that are noncompetitive N-methyl-D-aspartate receptor antagonists with neuroprotective properties

Autor: Robert N. McBurney, John F. W. Keana, Michael W. Scherz, C Jahr, Steven Finkbeiner, J B Fischer, P N Hamilton, S M Smith, Courtney Stevens, A C Server

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 86(14)

Four diarylguanidine derivatives were synthesized. These compounds were found to displace, at submicromolar concentrations, 3H-labeled 1-[1-(2-thienyl)cyclohexyl]piperidine and (+)-[3H]MK-801 from phencyclidine receptors in brain membrane preparation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda77bd2dbfa0757af4d074f66124959
https://pubmed.ncbi.nlm.nih.gov/2546162

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