Výsledky vyhledávání - "Michael W. Rossi"

Functional status, healthcare utilization, and the costs of liver transplantation

Autor: Michael W. Rossi, Marina Serper, Kim M. Olthoff, Abraham Shaked, David S. Goldberg, Therese Bittermann, Arwin Thomasson

Publikováno v: American Journal of Transplantation. 18:1187-1196

The Model for End-Stage Liver Disease (MELD) score predicts higher transplant healthcare utilization and costs; however, the independent contribution of functional status towards costs is understudied. The study objective was to evaluate the associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083c0da5fb0bdda6ec5ff05734a2771b
https://doi.org/10.1111/ajt.14576

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Serine phosphorylation of p60 tumor necrosis factor receptor by PKC-δ in TNF-α-activated neutrophils

Autor: Young-Han Song, Helen M. Korchak, Michael W. Rossi, Laurie E. Kilpatrick

Publikováno v: Europe PubMed Central

Tumor necrosis factor-alpha (TNF-alpha) triggers degranulation and oxygen radical release in adherent neutrophils. The p60TNF receptor (p60TNFR) is responsible for proinflammatory signaling, and protein kinase C (PKC) is a candidate for the regulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bfe0b8a16c57e31a7c2e9d3b82f314
https://doi.org/10.1152/ajpcell.2000.279.6.c2011

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Selective Role for β-Protein Kinase C in Signaling for O⨪2 Generation but Not Degranulation or Adherence in Differentiated HL60 Cells

Autor: Laurie E. Kilpatrick, Michael W. Rossi, Helen M. Korchak

Publikováno v: Journal of Biological Chemistry. 273:27292-27299

A role for protein kinase C (PKC) isotypes is implicated in the activation of phagocytic cell functions. An antisense approach was used to selectively deplete beta-PKC, both betaI- and betaII-PKC, but not alpha-PKC, delta-PKC, or zeta-PKC in HL60 cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91125851e2b0e627a0715e2809550f72
https://doi.org/10.1074/jbc.273.42.27292

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Long chain acyl coenzyme A and signaling in neutrophils. An inhibitor of acyl coenzyme A synthetase, triacsin C, inhibits superoxide anion generation and degranulation by human neutrophils

Autor: Helen M. Korchak, L. H. Kane, Barbara E. Corkey, Michael W. Rossi

Publikováno v: Journal of Biological Chemistry. 269:30281-30287

Ligand-initiated activation of neutrophils triggers O2- generation, degranulation, phospholipid remodeling, and release of fatty acids such as arachidonate, oleate, and palmitate. Long chain acyl-CoA synthetase converts free fatty acids to acyl-CoA e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb08159ec893116c05e2cd150d1bf062
https://doi.org/10.1016/s0021-9258(18)43809-4

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Protein kinase C isotypes and signaling in neutrophils. Differential substrate specificities of a translocatable calcium- and phospholipid-dependent beta-protein kinase C and a phospholipid-dependent protein kinase which is inhibited by long chain fatty acyl coenzyme A

Autor: Barbara E. Corkey, Michael W. Rossi, R B Johnston, Wayne A. Phillips, Helen M. Korchak, T Fujiki, Subrata Majumdar, Ora M. Rosen, S Disa, C F Queen

Publikováno v: Journal of Biological Chemistry. 266:9285-9294

Neutrophils possess a classical Ca2+, phosphatidyl serine (PS) and diglyceride (DG)-dependent protein kinase C (beta-PKC) which was translocatable from cytosol to membrane in response to elevated Ca2+ in the physiologic range or to pretreatment with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26d193a6abfc6194273d2b264cce9961
https://doi.org/10.1016/s0021-9258(18)31582-5

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Inositol polyphosphate derivative inhibits Na+ transport and improves fluid dynamics in cystic fibrosis airway epithelia

Autor: Sharon McNamara, Michael W. Rossi, Carsten Schultz, Carlo Dinkel, Carey Pennington, Mark Moody, Ray A. Caldwell, Sherif E. Gabriel, Alexis Traynor-Kaplan, Jonathan Widdicombe

Publikováno v: American journal of physiology. Cell physiology. 289(3)

Amiloride-sensitive, epithelial Na+ channel (ENaC)-mediated, active absorption of Na+ is elevated in the airway epithelium of cystic fibrosis (CF) patients, resulting in excess fluid removal from the airway lumen. This excess fluid/volume absorption

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5312e8db09e4bc0dc3fbe9146cf928b
https://pubmed.ncbi.nlm.nih.gov/15857902

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Protein kinase C isotypes and signal-transduction in human neutrophils: selective substrate specificity of calcium-dependent beta-PKC and novel calcium-independent nPKC

Autor: Michael W. Rossi, Subrata Majumdar, William M. Nauseef, Bryan D. Volpp, Lauren H. Kane, Helen M. Korchak

Publikováno v: Biochimica et biophysica acta. 1176(3)

Neutrophils possess at least two phospholipid-dependent forms of protein kinase C, a classical Ca/PS/DG-dependent beta-isotype of protein kinase C and a Ca-independent but PS/DG-dependent novel protein kinase C (nPKC) which we now demonstrate to have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64088ecdf0022e8037090cb560651ad2
https://pubmed.ncbi.nlm.nih.gov/8471629

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