Zobrazeno 1 - 10 of 55 pro vyhledávání: '"Michael W. Nestor"'
1
Akademický článek
Transcriptomic analysis of isolated and pooled human postmortem cerebellar Purkinje cells in autism spectrum disorders
Autor: Cheryl Brandenburg, Anthony J. Griswold, Derek J. Van Booven, Michaela B. C. Kilander, Jeannine A. Frei, Michael W. Nestor, Derek M. Dykxhoorn, Margaret A. Pericak-Vance, Gene J. Blatt
Publikováno v: Frontiers in Genetics, Vol 13 (2022)
At present, the neuronal mechanisms underlying the diagnosis of autism spectrum disorder (ASD) have not been established. However, studies from human postmortem ASD brains have consistently revealed disruptions in cerebellar circuitry, specifically r
Externí odkaz: https://doaj.org/article/9c8a29bc29c94fb5b3d1ea6922b36b67
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2
Akademický článek
Postnatal expression profiles of atypical cadherin FAT1 suggest its role in autism
Autor: Jeannine A. Frei, Cheryl J. Brandenburg, Jonathan E. Nestor, Didier M. Hodzic, Celine Plachez, Helen McNeill, Derek M. Dykxhoorn, Michael W. Nestor, Gene J. Blatt, Yu-Chih Lin
Publikováno v: Biology Open, Vol 10, Iss 6 (2021)
Genetic studies have linked FAT1 (FAT atypical cadherin 1) with autism spectrum disorder (ASD); however, the role that FAT1 plays in ASD remains unknown. In mice, the function of Fat1 has been primarily implicated in embryonic nervous system developm
Externí odkaz: https://doaj.org/article/b1e950df02b1419bbe7fff1784d77123
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4
Akademický článek
PeakCaller: an automated graphical interface for the quantification of intracellular calcium obtained by high-content screening
Autor: Elena Artimovich, Russell K. Jackson, Michaela B. C. Kilander, Yu-Chih Lin, Michael W. Nestor
Publikováno v: BMC Neuroscience, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background Intracellular calcium is an important ion involved in the regulation and modulation of many neuronal functions. From regulating cell cycle and proliferation to initiating signaling cascades and regulating presynaptic neurotransmit
Externí odkaz: https://doaj.org/article/603de27e268840c499faed39fc78c3c0
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5
Akademický článek
iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease
Autor: Chris M. Woodard, Brian A. Campos, Sheng-Han Kuo, Melissa J. Nirenberg, Michael W. Nestor, Matthew Zimmer, Eugene V. Mosharov, David Sulzer, Hongyan Zhou, Daniel Paull, Lorraine Clark, Eric E. Schadt, Sergio Pablo Sardi, Lee Rubin, Kevin Eggan, Mathew Brock, Scott Lipnick, Mahendra Rao, Stephen Chang, Aiqun Li, Scott A. Noggle
Publikováno v: Cell Reports, Vol 9, Iss 4, Pp 1173-1182 (2014)
Parkinson’s disease (PD) has been attributed to a combination of genetic and nongenetic factors. We studied a set of monozygotic twins harboring the heterozygous glucocerebrosidase mutation (GBA N370S) but clinically discordant for PD. We applied i
Externí odkaz: https://doaj.org/article/f58586c88b724b98b595eefa2674fd1d
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6
Beyond Mendelian Genetics: Anticipatory Biomedical Ethics and Policy Implications for the Use of CRISPR Together with Gene Drive in Humans
Autor: Michael W. Nestor, Richard L. Wilson
Publikováno v: Journal of Bioethical Inquiry. 17:133-144
Clustered regularly interspaced short palindromic repeats (CRISPR) genome editing has already reinvented the direction of genetic and stem cell research. For more complex diseases it allows scientists to simultaneously create multiple genetic changes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f1226020b40d48901431fd0c8863ad
https://doi.org/10.1007/s11673-019-09957-7
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