Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Michael W. Nestor"'
Autor:
Cheryl Brandenburg, Anthony J. Griswold, Derek J. Van Booven, Michaela B. C. Kilander, Jeannine A. Frei, Michael W. Nestor, Derek M. Dykxhoorn, Margaret A. Pericak-Vance, Gene J. Blatt
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
At present, the neuronal mechanisms underlying the diagnosis of autism spectrum disorder (ASD) have not been established. However, studies from human postmortem ASD brains have consistently revealed disruptions in cerebellar circuitry, specifically r
Externí odkaz:
https://doaj.org/article/9c8a29bc29c94fb5b3d1ea6922b36b67
Autor:
Jeannine A. Frei, Cheryl J. Brandenburg, Jonathan E. Nestor, Didier M. Hodzic, Celine Plachez, Helen McNeill, Derek M. Dykxhoorn, Michael W. Nestor, Gene J. Blatt, Yu-Chih Lin
Publikováno v:
Biology Open, Vol 10, Iss 6 (2021)
Genetic studies have linked FAT1 (FAT atypical cadherin 1) with autism spectrum disorder (ASD); however, the role that FAT1 plays in ASD remains unknown. In mice, the function of Fat1 has been primarily implicated in embryonic nervous system developm
Externí odkaz:
https://doaj.org/article/b1e950df02b1419bbe7fff1784d77123
Autor:
Brooke A. DeRosa, Jimmy El Hokayem, Elena Artimovich, Catherine Garcia-Serje, Andre W. Phillips, Derek Van Booven, Jonathan E. Nestor, Lily Wang, Michael L. Cuccaro, Jefery M. Vance, Margaret A. Pericak-Vance, Holly N. Cukier, Michael W. Nestor, Derek M. Dykxhoorn
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/580894a60b8042c7adcb6bc7d574935b
Autor:
Elena Artimovich, Russell K. Jackson, Michaela B. C. Kilander, Yu-Chih Lin, Michael W. Nestor
Publikováno v:
BMC Neuroscience, Vol 18, Iss 1, Pp 1-15 (2017)
Abstract Background Intracellular calcium is an important ion involved in the regulation and modulation of many neuronal functions. From regulating cell cycle and proliferation to initiating signaling cascades and regulating presynaptic neurotransmit
Externí odkaz:
https://doaj.org/article/603de27e268840c499faed39fc78c3c0
Autor:
Chris M. Woodard, Brian A. Campos, Sheng-Han Kuo, Melissa J. Nirenberg, Michael W. Nestor, Matthew Zimmer, Eugene V. Mosharov, David Sulzer, Hongyan Zhou, Daniel Paull, Lorraine Clark, Eric E. Schadt, Sergio Pablo Sardi, Lee Rubin, Kevin Eggan, Mathew Brock, Scott Lipnick, Mahendra Rao, Stephen Chang, Aiqun Li, Scott A. Noggle
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1173-1182 (2014)
Parkinson’s disease (PD) has been attributed to a combination of genetic and nongenetic factors. We studied a set of monozygotic twins harboring the heterozygous glucocerebrosidase mutation (GBA N370S) but clinically discordant for PD. We applied i
Externí odkaz:
https://doaj.org/article/f58586c88b724b98b595eefa2674fd1d
Autor:
Michael W. Nestor, Richard L. Wilson
The future of gene editing in humans will involve the use of CRISPR. How we think about the combination of the scientific, ethical, and moral aspects of this technology is paramount to the success or failure of CRISPR in humans. Unfortunately, the cu
Autor:
Michael W. Nestor, Richard L. Wilson
Publikováno v:
Journal of Bioethical Inquiry. 17:133-144
Clustered regularly interspaced short palindromic repeats (CRISPR) genome editing has already reinvented the direction of genetic and stem cell research. For more complex diseases it allows scientists to simultaneously create multiple genetic changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f1226020b40d48901431fd0c8863ad
https://doi.org/10.1007/s11673-019-09957-7
https://doi.org/10.1007/s11673-019-09957-7
Autor:
Michael W. Nestor, Richard L. Wilson
Publikováno v:
Anticipatory Ethics and The Use of CRISPR in Humans ISBN: 9783030983673
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da839a9c8bee3e0f60ad10a531992037
https://doi.org/10.1007/978-3-030-98368-0_6
https://doi.org/10.1007/978-3-030-98368-0_6
Autor:
Michael W. Nestor, Richard L. Wilson
Publikováno v:
Anticipatory Ethics and The Use of CRISPR in Humans ISBN: 9783030983673
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::821b03227ba8fbecaa802526e26ec63d
https://doi.org/10.1007/978-3-030-98368-0_5
https://doi.org/10.1007/978-3-030-98368-0_5