Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michael W. Malloy"'
Autor:
Harvey G. Roweth, Michael W. Malloy, Gregory J. Goreczny, Isabelle C. Becker, Qiuchen Guo, Elizabeth A. Mittendorf, Joseph E. Italiano, Sandra S. McAllister, Elisabeth M. Battinelli
Publikováno v:
Science advances. 8(41)
Despite abundant research demonstrating that platelets can promote tumor cell metastasis, whether primary tumors affect platelet-producing megakaryocytes remains understudied. In this study, we used a spontaneous murine model of breast cancer to show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f465178ed95303a16a201dc42926927c
https://pubmed.ncbi.nlm.nih.gov/36223471
https://pubmed.ncbi.nlm.nih.gov/36223471
Autor:
Qiuchen Guo, Michael W. Malloy, Harvey G. Roweth, Sandra S. McAllister, Joseph E. Italiano, Elisabeth M. Battinelli
Publikováno v:
Blood advances. 6(20)
Programmed death ligand 1 (PD-L1) is an immune checkpoint protein that suppresses cytotoxic T lymphocytes and is often overexpressed in cancers. Due to favorable clinical trial results, immune checkpoint inhibition (ICI) is part of Food and Drug Admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d4228936ed973b9048ecda344b6f75
https://pubmed.ncbi.nlm.nih.gov/35482455
https://pubmed.ncbi.nlm.nih.gov/35482455
Autor:
Italo Faria do Valle, Michael W. Malloy, Albert-László Barabási, Elisabeth M. Battinelli, Joseph Loscalzo, Sofia Moco, Denis Barron, Harvey G. Roweth
Publikováno v:
Nature Food
Nature Food, 2(3), 143-155. Springer Nature
do Valle, I F, Roweth, H G, Malloy, M W, Moco, S, Barron, D, Battinelli, E, Loscalzo, J & Barabási, A-L 2021, ' Network medicine framework shows that proximity of polyphenol targets and disease proteins predicts therapeutic effects of polyphenols ', Nature Food, vol. 2, no. 3, pp. 143-155 . https://doi.org/10.1038/s43016-021-00243-7
Nature Food, 2(3), 143-155. Springer Nature
do Valle, I F, Roweth, H G, Malloy, M W, Moco, S, Barron, D, Battinelli, E, Loscalzo, J & Barabási, A-L 2021, ' Network medicine framework shows that proximity of polyphenol targets and disease proteins predicts therapeutic effects of polyphenols ', Nature Food, vol. 2, no. 3, pp. 143-155 . https://doi.org/10.1038/s43016-021-00243-7
Polyphenols, natural products present in plant-based foods, play a protective role against several complex diseases through their antioxidant activity and by diverse molecular mechanisms. Here we develop a network medicine framework to uncover mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de184bd30181a5b179d56cf5a5ec1ba6
Autor:
Harvey G. Roweth, Italo Faria do Valle, Sofia Moco, Michael W. Malloy, Albert-László Barabási, Denis Barron, Elisabeth M. Battinelli, Joseph Loscalzo
Polyphenols, natural products present in plant-based foods, play a protective role against several complex diseases through their antioxidant activity and by diverse molecular mechanisms. Here we developed a network medicine framework to uncover the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e97a590bab2c3a4b0ae73b92de098d3d
https://doi.org/10.1101/2020.08.27.270173
https://doi.org/10.1101/2020.08.27.270173
Autor:
Michael W. Malloy, Joseph E. Italiano, Elisabeth M. Battinelli, Harvey G. Roweth, Qiuchen Guo
Publikováno v:
Blood. 138:1006-1006
Introduction: Programmed cell death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1) are important immune checkpoint proteins in cancer immunotherapy and targeted therapies against PD-L1 have significantly prolonged many patients' lives. Recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9db16915b8985d279551563573ee6ae9
https://doi.org/10.1182/blood-2021-151339
https://doi.org/10.1182/blood-2021-151339
Autor:
Kelly E. Johnson, Wendy Y. Chen, Jodi A. Forward, Elisabeth M. Battinelli, Saleh El-Husayni, Julia R. Ceglowski, Mason D. Tippy, Michael W. Malloy, Kellie R. Machlus, Rajesh Kulenthirarajan, Joseph E. Italiano, Harvey G. Roweth
Publikováno v:
Blood advances. 3(2)
It is now recognized that compounds released from tumor cells can activate platelets, causing the release of platelet-derived factors into the tumor microenvironment. Several of these factors have been shown to directly promote neovascularization and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cdfbbd42a1065ec519683ab97e491e1
https://pubmed.ncbi.nlm.nih.gov/30670536
https://pubmed.ncbi.nlm.nih.gov/30670536
Autor:
Robert Flaumenhaft, Michael W. Malloy, Elisabeth M. Battinelli, Jodi A. Forward, Julia R. Ceglowski, Joseph E. Italiano, Harvey G. Roweth
Publikováno v:
Blood. 134:1058-1058
Almost every platelet-derived protein originates from either megakaryocytes (MKs), or the endocytosis of factors within blood circulation. These endocytosed factors can be locally released upon platelet activation to regulate hemostasis, or to promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f96d0ef40665d9a4a0c8211764ce1589
https://doi.org/10.1182/blood-2019-131912
https://doi.org/10.1182/blood-2019-131912
Autor:
Michael W. Malloy, Sandra S. McAllister, Joseph E. Italiano, Kelly E. Johnson, Harvey G. Roweth, Gregory J. Goreczny, Elisabeth M. Battinelli
Publikováno v:
Blood. 134:12-12
The first association between platelets and cancer dates back to the 19th century, where unexpected blood clots were perceived as a potential forewarning of occult malignancy. More recently, platelets have been shown to promote the progression of sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb8b8dca1d969cc6ccbb101800232fbc
https://doi.org/10.1182/blood-2019-124894
https://doi.org/10.1182/blood-2019-124894