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pro vyhledávání: '"Michael W. Konrad"'
Autor:
Michael W. Konrad
Publikováno v:
PeerJ, Vol 4, p e2771 (2016)
The body of the ascidian tunicate Corella inflata is relatively transparent. Thus, the circulatory system can be visualized by injecting high molecular weight fluorescein labeled dextran into the heart or the large vessels at the ends of the heart wi
Externí odkaz:
https://doaj.org/article/8597c532448a4a1a8f964e9f29c0d23b
Autor:
Michael W. Konrad
BackgroundTunicates comprise an invertebrate, chordate subphylum which has been shown to be the closest group to vertebrates. Colonial tunicates are clusters of genetic clones generated asexually from a single free swimming larval “tadpole”. Each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1269114e83924020314e1d6fe2dc2f
https://doi.org/10.21203/rs.3.rs-655370/v1
https://doi.org/10.21203/rs.3.rs-655370/v1
Autor:
Michael W Konrad
Development of the adult ascidian tunicate starts when the tadpole larvae attaches to a surface. In approximately two days the solid tadpole will metamorphose into two joined concentric hollow cylinders. The outer cylinder is the body and the inner c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9d5e33f3c3923c74d26862ba986466
Autor:
Michael W Konrad
The ascidian tunicate Corella inflata is relatively transparent compared to other solitary tunicates and the circulatory system can be visualized by injecting high molecular weight fluorescein labeled dextran into the beating heart or the large vesse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69cc6033823febaa02e9e804629c4be
Autor:
Michael W. Konrad
Publikováno v:
Annals of the New York Academy of Sciences. 84:678-684
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25106a0dc2aa739addbbeca3c1f5cd8d
https://doi.org/10.1111/j.1749-6632.1960.tb39100.x
https://doi.org/10.1111/j.1749-6632.1960.tb39100.x
Autor:
Michael W. Konrad, Joel I. Bolonick
Publikováno v:
Journal of the American Chemical Society. 118:10989-10994
Molecular dynamics simulations were used to model the response of several double-stranded dodecamers to gradually increasing tension applied to the opposing 3‘ ends of the two polynucleotide strands. At forces between 0.80 and 1.45 nN, depending on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::645b47f0758c78367d70b59fd30ff7a6
https://doi.org/10.1021/ja961751x
https://doi.org/10.1021/ja961751x
Autor:
Michael W. Konrad, Eric C. Groves, Alfred Rudolph, Edward C. Bradley, Gary Goodman, Susanne K. DeWitt, Robert L. Krigel, Evan M. Hersh
Publikováno v:
Journal of Immunotherapy. 12:55-63
The administration of recombinant interleukin-2 as an i.v. bolus at dose levels of from 1 to 30 MIU/m2 to patients with cancer induces easily measurable serum interferon-gamma levels of 1 to 500 U/ml. After a lag of 1 h, interferon-gamma rises to a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02c37a1a9c4191ba6a365c3538fb3bb
https://doi.org/10.1097/00002371-199207000-00007
https://doi.org/10.1097/00002371-199207000-00007
Autor:
Yihshing Shih, Frederick J. Meyers, Eric S. Groves, Michael W. Konrad, Anne Childs, Carolyn M. Paradise, M. Kim Warren
Publikováno v:
European Journal of Immunology. 22:727-733
Polyethylene glycolated (pegylated) interleukin-2 (PEG IL-2) was administered as a weekly i.v. bolus to patients with metastatic cancer in a phase-I trial. Efficacy, toxicity and pharmacokinetics have been described previously. To explore mechanism o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7388cad697608804d5fe3fc767091e1
https://doi.org/10.1002/eji.1830220316
https://doi.org/10.1002/eji.1830220316
Autor:
Jane Hudson, Michael W. Konrad, Alfred R. Rudolph, Anne Childs, Eric S. Groves, Kenneth W. Zamkoff
Publikováno v:
Journal of Immunotherapy. 11:103-110
Twenty patients with advanced cancer for which there was no effective standard therapy or whose disease was refractory to standard therapy were treated with recombinant macrophage colony-stimulating factor (rM-CSF). The rM-CSF was administered by int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bffeb61db317e4ffd526114ecfd6bf1
https://doi.org/10.1097/00002371-199202000-00004
https://doi.org/10.1097/00002371-199202000-00004
Autor:
Michael W. Konrad
Publikováno v:
Pharmaceutical Biotechnology ISBN: 9781461362562
Our immune system recognizes infecting organisms and protein toxins as foreign, and by inactivating them often protects us from harmful effects. However, a protein therapeutic may also be seen as foreign. The result of being perceived as foreign can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5a3fdf1efe502ca9ab67095445590ac
https://doi.org/10.1007/978-1-4615-2898-2_14
https://doi.org/10.1007/978-1-4615-2898-2_14