Výsledky vyhledávání - "Michael W. Hornung"

Characterization of the Mechanistic Linkages Between Iodothyronine Deiodinase Inhibition and Impaired Thyroid-Mediated Growth and Development in Xenopus laevis Using Iopanoic Acid

Autor: Jonathan T Haselman, Jennifer H Olker, Patricia A Kosian, Joseph J Korte, Jeffrey S Denny, Joseph E Tietge, Michael W Hornung, Sigmund J Degitz

Publikováno v: Toxicol Sci

Iodothyronine deiodinases (DIO) are key enzymes that influence tissue-specific thyroid hormone levels during thyroid-mediated amphibian metamorphosis. Within the larger context of evaluating chemicals for thyroid system disrupting potential, chemical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb6524a19ef791df91df42dd10d0e95
https://doi.org/10.1093/toxsci/kfac014

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Targeted Pathway-based In Vivo Testing Using Thyroperoxidase Inhibition to Evaluate Plasma Thyroxine as a Surrogate Metric of Metamorphic Success in Model Amphibian Xenopus laevis

Autor: Joseph J. Korte, Jeffrey S. Denny, Jennifer H Olker, Joseph A. Swintek, Patricia A. Kosian, Joseph E. Tietge, John W. Nichols, Sigmund J. Degitz, Jonathan T. Haselman, Michael W. Hornung

Publikováno v: Toxicol Sci

Chemical safety evaluation is in the midst of a transition from traditional whole-animal toxicity testing to molecular pathway-based in vitro assays and in silico modeling. However, to facilitate the shift in reliance on apical effects for risk asses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0f2fa073d9a14784133cb3ac98477b
https://doi.org/10.1093/toxsci/kfaa036

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Cross-species comparison of chemical inhibition of human and Xenopus iodotyrosine deiodinase

Autor: Jennifer H. Olker, Joseph J. Korte, Jonathan T. Haselman, Michael W. Hornung, Sigmund J. Degitz

Publikováno v: Aquatic toxicology (Amsterdam, Netherlands). 249

The transition to include in vitro-based data in chemical hazard assessment has resulted in the development and implementation of screening assays to cover a diversity of biological pathways, including recently added assays to interrogate chemical di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca00f1d4e60fbb442259ca1906b6de6
https://pubmed.ncbi.nlm.nih.gov/35767922

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Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases

Autor: Joseph J. Korte, Sigmund J. Degitz, Phillip C. Hartig, Jessica P Christensen, Jennifer H Olker, Paige M Kent, Carsten Knutsen, Mary C. Cardon, Michael W. Hornung, Jeffrey S. Denny

Publikováno v: Toxicological Sciences. 168:430-442

Deiodinase enzymes play an essential role in converting thyroid hormones between active and inactive forms by deiodinating the pro-hormone thyroxine (T4) to the active hormone triiodothyronine (T3) and modifying T4 and T3 to inactive forms. Chemical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8efb5fab58a9168c1f0124bb1a0ce01
https://doi.org/10.1093/toxsci/kfy302

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In vitro screening for chemical inhibition of the iodide recycling enzyme, iodotyrosine deiodinase

Autor: Sigmund J. Degitz, Jennifer H Olker, Phillip C. Hartig, Mary C. Cardon, Jonathan T. Haselman, Joseph J. Korte, Jeffrey S. Denny, Michael W. Hornung

Publikováno v: Toxicol In Vitro

The iodide recycling enzyme, iodotyrosine deiodinase (IYD), is a largely unstudied molecular mechanism through which environmental chemicals can potentially cause thyroid disruption. This highly conserved enzyme plays an essential role in maintaining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e32d38a329beb29a438f2710808fe4
https://pubmed.ncbi.nlm.nih.gov/33352258

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Xenopus laevis and human type 3 iodothyronine deiodinase enzyme cross-species sensitivity to inhibition by ToxCast chemicals

Autor: Joseph J. Korte, Sally A. Mayasich, Phillip C. Hartig, Michael W. Hornung, Jennifer H Olker, Joseph O’Flanagan, Sigmund J. Degitz, Jeffrey S. Denny, Philip DeGoey

Publikováno v: Toxicol In Vitro

Deiodinase enzymes are critical for tissue-specific and temporal control of activation or inactivation of thyroid hormones during vertebrate development, including amphibian metamorphosis. We previously screened ToxCast chemicals for inhibitory activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba790009f960d28137c71f33bef83c0
https://doi.org/10.1016/j.tiv.2021.105141

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Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches

Autor: Steven O. Simmons, Sigmund J. Degitz, Joseph E. Tietge, Susan C. Laws, Jonathan T. Haselman, Kevin M. Crofton, Michael W. Hornung, Tammy E. Stoker, Pamela D. Noyes, Patience Browne, Katie Paul Friedman, Mary E. Gilbert, Stan Barone

Publikováno v: Environmental Health Perspectives

Background: Extensive clinical and experimental research documents the potential for chemical disruption of thyroid hormone (TH) signaling through multiple molecular targets. Perturbation of TH signaling can lead to abnormal brain development, cognit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1666bd79e1fbad555d42289de3f5f71a
https://pubmed.ncbi.nlm.nih.gov/31487205

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Metabolism of cyclic phenones in rainbow trout

Autor: Jose, Serrano, Mark A, Tapper, Richard C, Kolanczyk, Barbara R, Sheedy, Tylor, Lahren, Dean E, Hammermeister, Jeffrey S, Denny, Michael W, Hornung, Alena, Kubátová, Patricia A, Kosian, Jessica, Voelker, Patricia K, Schmieder

Publikováno v: Xenobiotica

1. Cyclic phenones are chemicals of interest to the USEPA and international community due to their potential for endocrine disrupting activity. 2. Prior to this report, there was very limited information addressing metabolism of cyclic phenones by fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e53dc9b3fec4de446856b1e69f946dd1
https://pubmed.ncbi.nlm.nih.gov/30888238

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Metabolism of cyclic phenones in rainbow trout in vitro assays

Autor: Michael W. Hornung, Jessica Voelker, Tylor J. Lahren, Patricia K. Schmieder, Dean E. Hammermeister, Patricia A. Kosian, Mark A. Tapper, Jose Serrano, Alena Kubátová, Barbara R. Sheedy, Richard C. Kolanczyk, Jeffrey S. Denny

1. Cyclic phenones are chemicals of interest to the USEPA due to their potential for endocrine disruption to aquatic and terrestrial species. 2. Prior to this report, there was very limited information addressing metabolism of cyclic phenones by fish

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b2b217c66f4c2a80cf270577040aaf

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