Výsledky vyhledávání - "Michael W. Hager"

Simple In Vitro Assay To Evaluate the Incorporation Efficiency of Ribonucleotide Analog 5′-Triphosphates into RNA by Human Mitochondrial DNA-Dependent RNA Polymerase

Autor: Paul Collop, Kasinath Sana, Abel De La Rosa, Damien Kuiper, Gregory R. Bluemling, Alexander A. Kolykhalov, Shuli Mao, Bharat P. Gurale, Gaofei Lu, Michael W. Hager, George R. Painter

Publikováno v: Antimicrobial Agents and Chemotherapy

There is a growing body of evidence suggesting that some ribonucleoside/ribonucleotide analogs may be incorporated into mitochondrial RNA by human mitochondrial DNA-dependent RNA polymerase (POLRMT) and disrupt mitochondrial RNA synthesis. An assessm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9268686fe620921e77ca2d766f27f5
https://doi.org/10.1128/aac.01830-17

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Analysis of Ribonucleotide 5′-Triphosphate Analogs as Potential Inhibitors of Zika Virus RNA-Dependent RNA Polymerase by Using Nonradioactive Polymerase Assays

Autor: Damien Kuiper, Bharat P. Gurale, Paul Collop, Michael W. Hager, George R. Painter, Abel De La Rosa, Gregory R. Bluemling, Gaofei Lu, Alexander A. Kolykhalov

Zika virus (ZIKV) is an emerging human pathogen that is spreading rapidly through the Americas and has been linked to the development of microcephaly and to a dramatically increased number of Guillain-Barré syndrome cases. Currently, no vaccine or t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1a545c4f485ea11a8a29f1fae58301
https://europepmc.org/articles/PMC5328514/

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Synthesis and evaluation of 2′-substituted cyclobutyl nucleosides and nucleotides as potential anti-HIV agents

Autor: Dennis C. Liotta, Yongfeng Li, Raymond F. Schinazi, Shuli Mao, Kimberlynne D. Becnel, Michael W. Hager

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 17:3398-3401

A series of 2′-substituted cyclobutyl nucleoside analogs were efficiently prepared by constructing the core cyclobutyl ring using different [2+2] cycloaddition approaches. The triphosphate derivative of a cyclobutyl nucleoside was also synthesized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1ab0180a50e2da70e0f343d449ea6b
https://doi.org/10.1016/j.bmcl.2007.03.094

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Time-Resolved Fluorescence Investigation of Energy Transfer in Compact Phenylacetylene Dendrimers

Autor: Michael W. Hager, Theodore Goodson, and Christopher B. Gorman, Mahinda I. Ranasinghe

Publikováno v: The Journal of Physical Chemistry B. 108:8543-8549

Excitation energy transfer dynamics in light-harvesting dendritic macromolecules has generated a great deal of interest due to the fact that such systems can be used in photovoltaic and light-emitting devices. Studies on phenylacetylene-based dendrim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d811f0263c16ebed0b5aa3b8382e024c
https://doi.org/10.1021/jp036877c

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Molecular Structure−Property Relationships for Electron-Transfer Rate Attenuation in Redox-Active Core Dendrimers

Autor: and Hanna Sierzputowska-Gracz, Brandon L. Parkhurst, Christopher B. Gorman, Carol A. Haney, Jennifer C. Smith, Michael W. Hager

Publikováno v: Journal of the American Chemical Society. 121:9958-9966

Two series of redox-active, iron−sulfur core dendrimers of the general structure (nBu4N)2[Fe4S4(S-Dend)4] (Dend = dendrons of generations 1 through 4) were prepared. Heterogeneous electron-transfer rate constants indicated that the rigid series of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2dac94b609eea0d22351c099b1b5a24
https://doi.org/10.1021/ja990875h

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Use of a Paramagnetic Core to Affect Longitudinal Nuclear Relaxation in DendrimersA Tool for Probing Dendrimer Conformation

Autor: Christopher B. Gorman, Brandon L. Parkhurst, Jennifer C. Smith, Michael W. Hager

Publikováno v: Macromolecules. 31:815-822

The longitudinal relaxation time constants (T 1 ) of the protons in a series of dendrimers that alternatively had paramagnetic ([Fe 4 S 4 (SR) 4 ] 2- , R = dendron) and diamagnetic (tetraphenylmethane) cores were compared. The T 1 values of the pheny

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a20b3c323275b1f2e315049e9d9341c7
https://doi.org/10.1021/ma9714979

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