Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michael W. H. Coughtrie"'
Publikováno v:
ACS Omega, Vol 5, Iss 12, Pp 6872-6887 (2020)
Externí odkaz:
https://doaj.org/article/0b110f14fc6d4f0180b00a1b8ec71aef
Autor:
Yuejian Liu, Michael W. H. Coughtrie
Publikováno v:
Pharmaceutics, Vol 9, Iss 3, p 32 (2017)
Uridine diphosphate-glucuronosyltransferases (UGTs) are phase 2 conjugation enzymes mainly located in the endoplasmic reticulum (ER) of the liver and many other tissues, and can be recovered in artificial ER membrane preparations (microsomes). They c
Externí odkaz:
https://doaj.org/article/8d99ec3b95b342048cdc366c14790ce1
Publikováno v:
J Assist Reprod Genet
PURPOSE: Assisted reproduction technologies (ART) are associated with increased risks of pregnancy complications and obstetric interventions. Here, we aimed to determine if ART affects placental inflammation and oxidative stress as a mechanism for un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17478d1ff2c673990311baeaf410d07f
https://doi.org/10.1007/s10815-021-02371-2
https://doi.org/10.1007/s10815-021-02371-2
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 48(9)
1. The UDP-glucuronosyltransferase (UGT) enzymes are important in the metabolism, elimination and detoxification of many xenobiotics and endogenous compounds. As extrapolation of in vitro kinetics of drug metabolizing enzymes to predict in vivo clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50a8c529f844a970441847a36badbb7e
https://pubmed.ncbi.nlm.nih.gov/28868965
https://pubmed.ncbi.nlm.nih.gov/28868965
Autor:
A. Gerlienke Schuur, Ingeborg van Leeuwen-Bol, Willeke M. C. Jong, Åke Bergman, Michael W. H. Coughtrie, Abraham Brouwer, Theo J. Visser
Publikováno v:
Toxicological Sciences. 45:188-194
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::297c77c99603c5d9590457ee1c698895
https://doi.org/10.1093/toxsci/45.2.188
https://doi.org/10.1093/toxsci/45.2.188
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 640
Since phase II reactions quantitatively represent the most important pathways involved in drug biotransformation, the development and the use of in vitro approaches to predict glucuronidation and sulfation are currently attracting intense interest to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::943ebc21d6f9d4bc3d5b9febb104a99c
https://pubmed.ncbi.nlm.nih.gov/20645060
https://pubmed.ncbi.nlm.nih.gov/20645060
Publikováno v:
Methods in enzymology. 400
Five human hepatic UDP-glucuronosyltransferases (UGTs) catalyze the facilitated excretion of more than 90% of drugs eliminated by glucuronidation. The substrate specificity of these UGTs has been examined using cloned expressed enzymes and liquid chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::043d2972f90c2284bda6f986f101194d
https://pubmed.ncbi.nlm.nih.gov/16399342
https://pubmed.ncbi.nlm.nih.gov/16399342
Autor:
Christopher R, Ireson, Donald J L, Jones, Samantha, Orr, Michael W H, Coughtrie, David J, Boocock, Marion L, Williams, Peter B, Farmer, William P, Steward, Andreas J, Gescher
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 11(1)
Curcumin, the yellow pigment in turmeric, prevents malignancies in the intestinal tract of rodents. It is under clinical evaluation as a potential colon cancer chemopreventive agent. The systemic bioavailability of curcumin is low, perhaps attributab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58e29a9971f5d14afb4451ff7deffdc2
https://pubmed.ncbi.nlm.nih.gov/11815407
https://pubmed.ncbi.nlm.nih.gov/11815407
The existence of multiple sulfotransferases (SULTS) was first discovered in 1958. Since then, any attempts to create a comprehensive text dedicated to sulfation and sulfotransferases have been rare and, thanks to rapid advances in molecular biology a
