Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Michael W Schmitt"'
Autor:
Thomas F Gajewski, John A Thompson, Sanjay Goel, Brendan D Curti, Elisabeth I Heath, Olivier Rixe, David C Smith, Celine Jacquemont, Tycel Phillips, Martin Gutierrez, Sahar Ansari, Andrew L Coveler, Svetomir N Markovic, Timothy M Kuzel, Amitkumar N Mehta, David L Bajor, Hun Ju Lee, Ajay K Gopal, Paolo Caimi, Ariel Topletz-Erickson, Peigen Zhou, Michael W Schmitt, Juneko E Grilley-Olson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Background SEA-CD40 is an investigational, non-fucosylated, humanized monoclonal IgG1 antibody that activates CD40, an immune-activating tumor necrosis factor receptor superfamily member. SEA-CD40 exhibits enhanced binding to activating FcγRIIIa, po
Externí odkaz:
https://doaj.org/article/997d45d0420040f2a6abbe4400763c7d
Autor:
Jan Clement Santiago, Jason D Goldman, Hong Zhao, Alec P Pankow, Fred Okuku, Michael W Schmitt, Lennie H Chen, C Alexander Hill, Corey Casper, Warren T Phipps, James I Mullins
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1008594 (2021)
Intra-host tumor virus variants may influence the pathogenesis and treatment responses of some virally-associated cancers. However, the intra-host variability of Kaposi sarcoma-associated herpesvirus (KSHV), the etiologic agent of Kaposi sarcoma (KS)
Externí odkaz:
https://doaj.org/article/c6ffb8a03692414c8766637cbe300824
Publikováno v:
PLoS Genetics, Vol 9, Iss 9, p e1003794 (2013)
Mitochondrial DNA (mtDNA) is believed to be highly vulnerable to age-associated damage and mutagenesis by reactive oxygen species (ROS). However, somatic mtDNA mutations have historically been difficult to study because of technical limitations in ac
Externí odkaz:
https://doaj.org/article/e464454abd8047f597d337bbd6be20bf
Autor:
Ashwini S. Kamath-Loeb, Jiang-Cheng Shen, Michael W. Schmitt, Brendan F. Kohrn, Keith R. Loeb, Elihu H. Estey, Jin Dai, Sylvia Chien, Lawrence A. Loeb, Pamela S. Becker
Publikováno v:
Leuk Res
Mutations characterize diverse human cancers; there is a positive correlation between elevated mutation frequency and tumor progression. One exception is acute myeloid leukemia (AML), which has few clonal single nucleotide mutations. We used highly s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7390717a06a18a29bb52e0c9a7352b66
https://europepmc.org/articles/PMC9014797/
https://europepmc.org/articles/PMC9014797/
Autor:
David Lawrence Bajor, Martin Gutierrez, Gina M. Vaccaro, Ashiq Masood, Ursa Brown-Glaberman, Juneko E. Grilley-Olson, Hedy L. Kindler, Mark Zalupski, Elisabeth I. Heath, Sarina Anne Piha-Paul, Peigen Zhou, Hailing Lu, Sahar Ansari, Jonathan Hayman, Michael W. Schmitt, Andrew L. Coveler
Publikováno v:
Journal of Clinical Oncology. 40:559-559
559 Background: SEA-CD40 is an investigational nonfucosylated IgG1 monoclonal agonistic antibody targeted to CD40, expressed on antigen-presenting cells. SEA-CD40 binds with increased affinity to FcγRIIIa resulting in enhanced effector function and
Autor:
Clement Santiago, James I. Mullins, Michael W. Schmitt, Jason D Goldman, C. Alexander Hill, Fred Okuku, Hong Zhao, Lennie Chen, Corey Casper, Alec P. Pankow, Warren Phipps
Intra-host evolved tumor virus variants have provided insights into the risk, pathogenesis and treatment responses of associated cancers. However, the intra-host variability of Kaposi sarcoma-associated herpesvirus (KSHV), the etiologic agent of Kapo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ea1c4701e1f3f5513fc531f1ff6a2a
Autor:
Andrew L. Coveler, Gina M. Vaccaro, Mark M. Zalupski, Milind Javle, David L. Bajor, Hedy L. Kindler, Ursa Brown-Glaberman, Michael W. Schmitt, Anthony F. Shields, Juneko E. Grilley-Olson, Olumide B. Gbolahan, Martin Gutierrez, Ashiq Masood
Publikováno v:
Journal of Clinical Oncology. 39:TPS451-TPS451
TPS451 Background: SEA-CD40 is an investigational non-fucosylated, humanized IgG1 monoclonal antibody directed against CD40, a co-stimulatory receptor expressed on antigen-presenting cells (APCs). Activation of CD40 on APCs upregulates cytokine produ
Autor:
Hong Zhao, C. Alexander Hill, James I. Mullins, Alec P. Pankow, Michael W. Schmitt, Jason D Goldman, Jan Clement Santiago, Corey Casper, Fred Okuku, Lennie Chen, Warren Phipps
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1008594 (2021)
PLoS Pathogens
PLoS Pathogens
Intra-host tumor virus variants may influence the pathogenesis and treatment responses of some virally-associated cancers. However, the intra-host variability of Kaposi sarcoma-associated herpesvirus (KSHV), the etiologic agent of Kaposi sarcoma (KS)
Autor:
Olivier Rixe, Timothy M. Kuzel, David Smith, Martin Gutierrez, Sahar Ansari, John A. Thompson, Sanjay Goel, Andrew L. Coveler, Michael W. Schmitt, Thomas F. Gajewski, David L. Bajor, Haley Neff-LaFord, Shyra Gardai, Elisabeth I. Heath, Brendan D. Curti, Svetomir N. Markovic, Celine Jacquemont, Juneko E. Grilley-Olson
Publikováno v:
Cancer Research. 80:5535-5535
CD40 is a co-stimulatory receptor of the TNF receptor superfamily expressed on antigen presenting cells (APCs). Antibodies targeting CD40 may have therapeutic benefit via multiple mechanisms including innate immune activation that can support generat
Autor:
Maureen Ryan, Lori Westendorf, Michael W. Schmitt, Mechthild Jonas, Esther Trueblood, Roma C. Yumul, Christopher E. Franz, Robert P. Lyon
Publikováno v:
Cancer Research. 80:2906-2906
The integrins are a large family of cell surface receptors with diverse roles in cellular adhesion, motility, and cytokinesis. Functional integrins exist as heterodimers consisting of single alpha and beta chains. Within this family, integrin beta-6