Zobrazeno 1 - 10
of 276
pro vyhledávání: '"Michael W Salter"'
Autor:
Mark R Hutchinson, Ian Gilron, Amanda Ross-White, R Andrew Moore, Dwight E Moulin, Maggie Z X Xiao, Marielle Balanaser, Meg Carley, Nader Ghasemlou, Michael W Salter
Publikováno v:
BMJ Open, Vol 12, Iss 4 (2022)
Introduction Evidence suggests a role for Central nervous system glia in pain transmission and in augmenting maladaptive opioid effects. Identification of drugs that modulate glia has guided the evaluation of glial suppression as a pain management st
Externí odkaz:
https://doaj.org/article/2f386e8551c3418eb89851d366373b63
Autor:
Shahrzad Ghazisaeidi, Arun Ramani, Parisa Shooshtari, Amy Tu, Katherine Halievski, David Finn, Sofia Assi, Milind Muley, Vivian Wang, Ameet Sengar, Rosanna Weksberg, Michael Brudno, Michael W Salter
Publikováno v:
Canadian Journal of Pain, Vol 0, Iss 0 (2019)
Introduction/Aim: Chronic pain affects 1 in 5 Canadians and costs over $43B annually, yet effective and safe treatment options remain elusive. Recent discoveries have brought to the forefront sex differences in mechanisms of pain as a potential expla
Externí odkaz:
https://doaj.org/article/6db73026970f4312bb259d80a4c80c5c
Hippocampal protein kinase D1 is necessary for DHPG-induced learning and memory impairments in rats.
Autor:
Wei Wang, Florian Duclot, Bradley R Groveman, Nicole Carrier, Haifa Qiao, Xiao-Qian Fang, Hui Wang, Wenkuan Xin, Xing-Hong Jiang, Michael W Salter, Xin-Sheng Ding, Mohamed Kabbaj, Xian-Min Yu
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195095 (2018)
BackgroundUnderstanding molecular mechanisms underlying the induction of learning and memory impairments remains a challenge. Recent investigations have shown that the activation of group I mGluRs (mGluR1 and mGluR5) in cultured hippocampal neurons b
Externí odkaz:
https://doaj.org/article/715f30ef33074c678a955ad5a7673164
Autor:
Justin You, Katarina Maksimovic, Mark N. Metri, Anneka Schoeppe, Karin Chen, Jooyun Lee, Jhune Rizsan Santos, Mohieldin M.M. Youssef, Michael W. Salter, Jeehye Park
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e37926- (2024)
Microglia have been increasingly implicated in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Dectin-1, encoded by the Clec7a gene, is highly upregulated in a specific microglial response state called disease-associated mi
Externí odkaz:
https://doaj.org/article/caeeeb00c43a4748918e2e9af65f04d1
Autor:
Eleonora Maino, Ori Scott, Samar Z. Rizvi, Wing Suen Chan, Shagana Visuvanathan, Youssif Ben Zablah, Hongbin Li, Ameet S. Sengar, Michael W. Salter, Zhengping Jia, Janet Rossant, Ronald D. Cohn, Bin Gu, Evgueni A. Ivakine
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/102714651e424d538637bc0d58cdac43
Autor:
Theresa H. Tam, Wenbo Zhang, YuShan Tu, Janice L. Hicks, Sophia Farcas, Doyeon Kim, Michael W. Salter
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114293- (2024)
Summary: Chronic pain is associated with alterations in fundamental cellular processes. Here, we investigate whether Beclin 1, a protein essential for initiating the cellular process of autophagy, is involved in pain processing and is targetable for
Externí odkaz:
https://doaj.org/article/b7003184086941b8b3f90d3cb3df746e
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51433 (2012)
Kainate receptors (KARs) are a class of ionotropic glutamate receptors that are expressed throughout the central nervous system. The function and subcellular localization of KARs are tightly regulated by accessory proteins. We have previously identif
Externí odkaz:
https://doaj.org/article/ec21614981b44242a90f75645b11e2a7
Autor:
David Ng, Graham M Pitcher, Rachel K Szilard, Andréa Sertié, Marijana Kanisek, Steven J Clapcote, Tatiana Lipina, Lorraine V Kalia, Daisy Joo, Colin McKerlie, Miguel Cortez, John C Roder, Michael W Salter, Roderick R McInnes
Publikováno v:
PLoS Biology, Vol 7, Iss 2, p e41 (2009)
The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Here we report that neuropilin tolloid-like 1 (Neto1), a complement C1r/C1s, U
Externí odkaz:
https://doaj.org/article/3b93d0508888458dabaff426a1a4130a
Autor:
Kartik S. Pradeepan, Fraser P. McCready, Wei Wei, Milad Khaki, Wenbo Zhang, Michael W. Salter, James Ellis, Julio Martinez-Trujillo
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 2, Pp 100290- (2024)
Background: Mutations in MECP2 predominantly cause Rett syndrome and can be modeled in vitro using human stem cell–derived neurons. Patients with Rett syndrome have signs of cortical hyperexcitability, such as seizures. Human stem cell–derived ME
Externí odkaz:
https://doaj.org/article/bf64c74f1669454c9420b1a4508cfb26
Publikováno v:
Annual Review of Pharmacology and Toxicology. 63:565-583
The study of chronic pain continues to generate ever-increasing numbers of publications, but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex-specific mechanisms underlying chronic pain has resulted in a surge of st