Zobrazeno 1 - 10 of 152 pro vyhledávání: '"Michael W Pennington"'
1
Akademický článek
Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver.
Autor: Yuqing Wang, Ayrea Hurley, Marco De Giorgi, Mark R Tanner, Rong-Chi Hu, Michael W Pennington, William R Lagor, Christine Beeton
Publikováno v: PLoS ONE, Vol 18, Iss 4, p e0283996 (2023)
Targeting the Kv1.3 potassium channel has proven effective in reducing obesity and the severity of animal models of autoimmune disease. Stichodactyla toxin (ShK), isolated from the sea anemone Stichodactyla helianthus, is a potent blocker of Kv1.3. S
Externí odkaz: https://doaj.org/article/07bb24c77595445685048ba486dfdb66
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2
Akademický článek
Computational design of peptides to target NaV1.7 channel with high potency and selectivity for the treatment of pain
Autor: Phuong T Nguyen, Hai M Nguyen, Karen M Wagner, Robert G Stewart, Vikrant Singh, Parashar Thapa, Yi-Je Chen, Mark W Lillya, Anh Tuan Ton, Richard Kondo, Andre Ghetti, Michael W Pennington, Bruce Hammock, Theanne N Griffith, Jon T Sack, Heike Wulff, Vladimir Yarov-Yarovoy
Publikováno v: eLife, Vol 11 (2022)
The voltage-gated sodium NaV1.7 channel plays a key role as a mediator of action potential propagation in C-fiber nociceptors and is an established molecular target for pain therapy. ProTx-II is a potent and moderately selective peptide toxin from ta
Externí odkaz: https://doaj.org/article/61a7e4bc52cf45b98b9c1e6f378c835a
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3
Akademický článek
A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation.
Autor: M Harunur Rashid, Germano Heinzelmann, Redwan Huq, Rajeev B Tajhya, Shih Chieh Chang, Sandeep Chhabra, Michael W Pennington, Christine Beeton, Raymond S Norton, Serdar Kuyucak
Publikováno v: PLoS ONE, Vol 8, Iss 11, p e78712 (2013)
The voltage-gated potassium channel Kv1.3 is a well-established target for treatment of autoimmune diseases. ShK peptide from a sea anemone is one of the most potent blockers of Kv1.3 but its application as a therapeutic agent for autoimmune diseases
Externí odkaz: https://doaj.org/article/73645594ae5140279a19c58876314432
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4
Akademický článek
Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes.
Autor: Shyny Koshy, Danli Wu, Xueyou Hu, Rajeev B Tajhya, Redwan Huq, Fatima S Khan, Michael W Pennington, Heike Wulff, Patricia Yotnda, Christine Beeton
Publikováno v: PLoS ONE, Vol 8, Iss 10, p e76740 (2013)
Natural killer (NK) cells are large granular lymphocytes that participate in both innate and adaptive immune responses against tumors and pathogens. They are also involved in other conditions, including organ rejection, graft-versus-host disease, rec
Externí odkaz: https://doaj.org/article/9d49b71d5a4e498ba0b089b1c075835f
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7
Akademický článek
Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK
Autor: Michael W. Pennington, Shih Chieh Chang, Satendra Chauhan, Redwan Huq, Rajeev B. Tajhya, Sandeep Chhabra, Raymond S. Norton, Christine Beeton
Publikováno v: Marine Drugs, Vol 13, Iss 1, Pp 529-542 (2015)
ShK, from the sea anemone Stichodactyla helianthus, is a 35-residue disulfide-rich peptide that blocks the voltage-gated potassium channel Kv1.3 at ca. 10 pM and the related channel Kv1.1 at ca. 16 pM. We developed an analog of this peptide, ShK-186,
Externí odkaz: https://doaj.org/article/c1c30af770e04c0a8a922513e4d0220d
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