Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Michael W Pennington"'
Autor:
Yuqing Wang, Ayrea Hurley, Marco De Giorgi, Mark R Tanner, Rong-Chi Hu, Michael W Pennington, William R Lagor, Christine Beeton
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283996 (2023)
Targeting the Kv1.3 potassium channel has proven effective in reducing obesity and the severity of animal models of autoimmune disease. Stichodactyla toxin (ShK), isolated from the sea anemone Stichodactyla helianthus, is a potent blocker of Kv1.3. S
Externí odkaz:
https://doaj.org/article/07bb24c77595445685048ba486dfdb66
Autor:
Phuong T Nguyen, Hai M Nguyen, Karen M Wagner, Robert G Stewart, Vikrant Singh, Parashar Thapa, Yi-Je Chen, Mark W Lillya, Anh Tuan Ton, Richard Kondo, Andre Ghetti, Michael W Pennington, Bruce Hammock, Theanne N Griffith, Jon T Sack, Heike Wulff, Vladimir Yarov-Yarovoy
Publikováno v:
eLife, Vol 11 (2022)
The voltage-gated sodium NaV1.7 channel plays a key role as a mediator of action potential propagation in C-fiber nociceptors and is an established molecular target for pain therapy. ProTx-II is a potent and moderately selective peptide toxin from ta
Externí odkaz:
https://doaj.org/article/61a7e4bc52cf45b98b9c1e6f378c835a
Autor:
M Harunur Rashid, Germano Heinzelmann, Redwan Huq, Rajeev B Tajhya, Shih Chieh Chang, Sandeep Chhabra, Michael W Pennington, Christine Beeton, Raymond S Norton, Serdar Kuyucak
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78712 (2013)
The voltage-gated potassium channel Kv1.3 is a well-established target for treatment of autoimmune diseases. ShK peptide from a sea anemone is one of the most potent blockers of Kv1.3 but its application as a therapeutic agent for autoimmune diseases
Externí odkaz:
https://doaj.org/article/73645594ae5140279a19c58876314432
Autor:
Shyny Koshy, Danli Wu, Xueyou Hu, Rajeev B Tajhya, Redwan Huq, Fatima S Khan, Michael W Pennington, Heike Wulff, Patricia Yotnda, Christine Beeton
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76740 (2013)
Natural killer (NK) cells are large granular lymphocytes that participate in both innate and adaptive immune responses against tumors and pathogens. They are also involved in other conditions, including organ rejection, graft-versus-host disease, rec
Externí odkaz:
https://doaj.org/article/9d49b71d5a4e498ba0b089b1c075835f
Autor:
Hai M Nguyen, Phuong T Nguyen, Karen M Wagner, Robert G Stewart, Vikrant Singh, Parashar Thapa, Yi-Je Chen, Mark W Lillya, Anh Tuan Ton, Richard Kondo, Andre Ghetti, Michael W Pennington, Bruce Hammock, Theanne N Griffith, Jon T Sack, Heike Wulff, Vladimir Yarov-Yarovoy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33893d32f016b01de0ad9310c1b61a77
https://doi.org/10.7554/elife.81727.sa2
https://doi.org/10.7554/elife.81727.sa2
Autor:
Hai M Nguyen, Phuong T Nguyen, Karen M Wagner, Robert G Stewart, Vikrant Singh, Parashar Thapa, Yi-Je Chen, Mark W Lillya, Anh Tuan Ton, Richard Kondo, Andre Ghetti, Michael W Pennington, Bruce Hammock, Theanne N Griffith, Jon T Sack, Heike Wulff, Vladimir Yarov-Yarovoy
The voltage-gated sodium NaV1.7 channel plays a key role as a mediator of action potential propagation in C-fiber nociceptors and is an established molecular target for pain therapy. ProTx-II is a potent and moderately selective peptide toxin from ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0988b85ef375b455a45538fdc58e6c47
https://escholarship.org/uc/item/35r029z1
https://escholarship.org/uc/item/35r029z1
Autor:
Phuong T. Nguyen, Hai M. Nguyen, Karen M. Wagner, Robert G. Stewart, Vikrant Singh, Parashar Thapa, Yi-Je Chen, Mark W. Lillya, Anh Tuan Ton, Richard Kondo, Andre Ghetti, Michael W. Pennington, Bruce Hammock, Theanne N. Griffith, Jon T. Sack, Heike Wulff, Vladimir Yarov-Yarovoy
The voltage-gated sodium NaV1.7 channel plays a key role as a mediator of action potential propagation in C-fiber nociceptors and is an established molecular target for pain therapy. ProTx-II is a potent and moderately selective peptide toxin from ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2d947d4b583c02645779462fd248962
https://doi.org/10.1101/2022.07.21.500925
https://doi.org/10.1101/2022.07.21.500925
Autor:
Phuong T. Nguyen, Hai M. Nguyen, Karen M. Wagner, Robert Stewart, Vikrant Singh, Parashar Thapa, Anh Tuan Ton, Richard P. Kondo, Andre Ghetti, Michael W. Pennington, Bruce Hammock, Theanne N. Griffith, Jon T. Sack, Heike Wulff, Vladimir Yarov-Yarovoy
Publikováno v:
Biophysical Journal. 122:309a
Autor:
Robert A. Neff, Mack Flinspach, Alan Gibbs, Amy Y. Shih, Natali A. Minassian, Yi Liu, Ross Fellows, Ondrej Libiger, Stephanie Young, Michael W. Pennington, Michael J. Hunter, Alan D. Wickenden
Publikováno v:
Journal of Biological Chemistry. 295:1315-1327
Autor:
Amy Y. Shih, Ondrej Libiger, Stephanie Young, Alan Gibbs, Alan D. Wickenden, Michael J. Hunter, Ross Fellows, Yi Liu, Robert A. Neff, Michael W. Pennington, Natali A. Minassian, Mack Flinspach
Publikováno v:
Journal of Biological Chemistry. 295:1315-1327
Pain is a significant public health burden in the United States, and current treatment approaches rely heavily on opioids, which often have limited efficacy and can lead to addiction. In humans, functional loss of the voltage-gated sodium channel Nav