The power to detect recent fragmentation events using genetic differentiation methods.

Autor: Michael W Lloyd, Lesley Campbell, Maile C Neel

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63981 (2013)

Habitat loss and fragmentation are imminent threats to biological diversity worldwide and thus are fundamental issues in conservation biology. Increased isolation alone has been implicated as a driver of negative impacts in populations associated wit

Externí odkaz: https://doaj.org/article/31f10863a02145a182b3048ee92700f4

A Genomically and Clinically Annotated Patient-Derived Xenograft Resource for Preclinical Research in Non–Small Cell Lung Cancer

Autor: Xing Yi Woo, Anuj Srivastava, Philip C. Mack, Joel H. Graber, Brian J. Sanderson, Michael W. Lloyd, Mandy Chen, Sergii Domanskyi, Regina Gandour-Edwards, Rebekah A. Tsai, James Keck, Mingshan Cheng, Margaret Bundy, Emily L. Jocoy, Jonathan W. Riess, William Holland, Stephen C. Grubb, James G. Peterson, Grace A. Stafford, Carolyn Paisie, Steven B. Neuhauser, R. Krishna Murthy Karuturi, Joshy George, Allen K. Simons, Margaret Chavaree, Clifford G. Tepper, Neal Goodwin, Susan D. Airhart, Primo N. Lara, Thomas H. Openshaw, Edison T. Liu, David R. Gandara, Carol J. Bult

Publikováno v: Cancer Res
Cancer research, vol 82, iss 22

Patient-derived xenograft (PDX) models are an effective preclinical in vivo platform for testing the efficacy of novel drugs and drug combinations for cancer therapeutics. Here we describe a repository of 79 genomically and clinically annotated lung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9a3e541cdb6b192fdaa15aa6615a2a
https://doi.org/10.1158/0008-5472.can-22-0948

Data from A Genomically and Clinically Annotated Patient-Derived Xenograft Resource for Preclinical Research in Non–Small Cell Lung Cancer

Autor: Carol J. Bult, David R. Gandara, Edison T. Liu, Thomas H. Openshaw, Primo N. Lara, Susan D. Airhart, Neal Goodwin, Clifford G. Tepper, Margaret Chavaree, Allen K. Simons, Joshy George, R. Krishna Murthy Karuturi, Steven B. Neuhauser, Carolyn Paisie, Grace A. Stafford, James G. Peterson, Stephen C. Grubb, William Holland, Jonathan W. Riess, Emily L. Jocoy, Margaret Bundy, Mingshan Cheng, James Keck, Rebekah A. Tsai, Regina Gandour-Edwards, Sergii Domanskyi, Mandy Chen, Michael W. Lloyd, Brian J. Sanderson, Joel H. Graber, Philip C. Mack, Anuj Srivastava, Xing Yi Woo

Patient-derived xenograft (PDX) models are an effective preclinical in vivo platform for testing the efficacy of novel drugs and drug combinations for cancer therapeutics. Here we describe a repository of 79 genomically and clinically annotated lung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5cefc3df68748c1456699cbfa512e4c
https://doi.org/10.1158/0008-5472.c.6514248.v1

Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment

Autor: Li Chen, Jacqueline Mudd, Michael Ittmann, Carol J. Bult, Amanda R. Kirane, Jelena Randjelovic, Stephen Scott, Yige Wu, Li Ding, Vashisht G. Yennu-Nanda, Jing Wang, Christopher D. Lanier, Maihi Fujita, Emilio Cortes-Sanchez, Sienna Rocha, Susan G. Hilsenbeck, Kian-Huat Lim, Fernanda Martins Rodrigues, Jill Rubinstein, Nicholas Mitsiades, Haiyin Lin, Jayamanna Wickramasinghe, Andrew Butterfield, Bryan E. Welm, Alana L. Welm, Jose P. Zevallos, Jason Held, Nicole B. Coggins, Song Cao, Yuanxin Xi, Brenda C. Timmons, Paul Lott, David Menter, Shunqiang Li, Tina Primeau, Fei Yang, Andrea Wang-Gillam, Ramaswamy Govindan, Dali Li, Brandi Davis-Dusenbery, Sara Seepo, Michael C. Wendl, Jeffrey Grover, Brian S. White, Clifford G. Tepper, Peter N. Robinson, Michael A. Davies, Zhengtao Chu, Michael W. Lloyd, Hua Sun, Xiaoshan Zhang, Tamara Stankovic, Dylan Fingerman, Anuj Srivastava, Luis G. Carvajal-Carmona, Don L. Gibbons, Lijun Yao, Rebecca Aft, Hongyong Zhang, Ismail Meraz, John DiGiovanna, Scott Kopetz, Ling Zhao, Guadalupe Polanco-Echeverry, Feng Chen, Jeremy Hoog, Matthew A. Wyczalkowski, George Xu, John D. Minna, Yi Xu, Julie Belmar, Xiaowei Xu, Luc Girard, Dennis A. Dean, Tijana Borovski, Chong-xian Pan, Cynthia X. Ma, Alexa Morales Arana, Yize Li, Turcin Saridogan, Steven B. Neuhauser, Sandra Scherer, Vicki Chin, Rose Tipton, David R. Gandara, Sherri R. Davies, Argun Akcakanat, Rajesh Patidar, Julie K. Schwarz, Soner Koc, Gao Boning, Michael Kim, Bryce P. Kirby, Yvonne A. Evrard, Hyunsil Park, Christian Frech, Chia-Kuei Mo, Ran Zhang, Brian A. Van Tine, Jonathan W. Reiss, Min Xiao, Xing Yi Woo, Tiffany Le, Ana Estrada, Xiaofeng Zheng, Jeffrey A. Moscow, Mourad Majidi, Nadezhda V. Terekhanova, Katherine Fuh, Erkan Yuca, Timothy A. Yap, Jianhua Zhang, Matthew J. Ellis, Shannon Westin, James H. Doroshow, Vito W. Rebecca, Moon S. Chen, Coya Tapia, Reyka G Jayasinghe, Jack A. Roth, Jithesh Augustine, Ryan C. Fields, Michae T. Tetzlaff, Michael T. Lewis, Kurt W. Evans, Ralph W. deVere White, Brian J. Sanderson, May Cho, Jeffrey H. Chuang, Tiffany Wallace, Ryan Jeon, Ted Toal, Matthew H. Bailey, Bert W. O'Malley, Katherine L. Nathanson, Qin Liu, Benjamin J. Raphael, Jingqin Luo, Salma Kaochar, Huiqin Chen, Rajasekharan Somasundaram, Daniel Cui Zhou, John F. DiPersio, Andrew V. Kossenkov, Bingliang Fang, Vanessa Jensen, Simone Zaccaria, Alexey Sorokin, Ai-Hong Ma, Sidharth V. Puram, Min Jin Ha, Meenhard Herlyn, R. Jay Mashl, Kelly Gale, Bingbing Dai, Lacey E. Dobrolecki, Chieh-Hsiang Yang, Funda Meric-Bernstam

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications

Development of candidate cancer treatments is a resource-intensive process, with the research community continuing to investigate options beyond static genomic characterization. Toward this goal, we have established the genomic landscapes of 536 pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a532801486680203051ed293ca8f82
https://doaj.org/article/e6286532f9bc487a87943a142621d7a3

PDXNet portal: patient-derived Xenograft model, data, workflow and tool discovery

Autor: Soner, Koc, Michael W, Lloyd, Jeffrey W, Grover, Nan, Xiao, Sara, Seepo, Sai Lakshmi, Subramanian, Manisha, Ray, Christian, Frech, John, DiGiovanna, Phillip, Webster, Steven, Neuhauser, Anuj, Srivastava, Xing Yi, Woo, Brian J, Sanderson, Brian, White, Paul, Lott, Lacey E, Dobrolecki, Heidi, Dowst, Yvonne A, Evrard, Tiffany A, Wallace, Jeffrey A, Moscow, James H, Doroshow, Nicholas, Mitsiades, Salma, Kaochar, Chong-Xian, Pan, Moon S, Chen, Luis, Carvajal-Carmona, Alana L, Welm, Bryan E, Welm, Michael T, Lewis, Ramaswamy, Govindan, Li, Ding, Shunqiang, Li, Meenhard, Herlyn, Michael A, Davies, Jack, Roth, Funda, Meric-Bernstam, Peter N, Robinson, Carol J, Bult, Brandi, Davis-Dusenbery, Dennis A, Dean, Ai-Hong, Ma

Publikováno v: NAR Cancer. 4

We created the PDX Network (PDXNet) portal (https://portal.pdxnetwork.org/) to centralize access to the National Cancer Institute-funded PDXNet consortium resources, to facilitate collaboration among researchers and to make these data easily availabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d35aa85be082bce5d59f5970be2f586
https://doi.org/10.1093/narcan/zcac014