Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michael W Knitz"'
Autor:
Eric T Clambey, Jacob Gadwa, Thomas E Bickett, Laurel B Darragh, Shilpa Bhatia, Miles Piper, Benjamin Van Court, Shiv Bhuvane, Diemmy Nguyen, Varuna Nangia, Sana D Karam, Michael W Knitz, Ayman J Oweida, Adam C Mueller, Douglas G Osborne, Xiyuan Bai, Sarah E Ferrara, Mary-Keara Boss, Andrew Goodspeed, Matthew A Burchill, Beth A Jirón Tamburini, Edward D Chan, Curtis R Pickering
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)
Background Numerous trials combining radiation therapy (RT) and immunotherapy in head and neck squamous cell carcinoma (HNSCC) are failing. Using preclinical immune cold models of HNSCC resistant to RT-immune checkpoint inhibitors, we investigate the
Externí odkaz:
https://doaj.org/article/cbf79a9cbfcd4744b19d4b8a1b088264
Autor:
Laurel B. Darragh, Jacob Gadwa, Tiffany T. Pham, Benjamin Van Court, Brooke Neupert, Nicholas A. Olimpo, Khoa Nguyen, Diemmy Nguyen, Michael W. Knitz, Maureen Hoen, Sophia Corbo, Molishree Joshi, Yonghua Zhuang, Maria Amann, Xiao-Jing Wang, Steven Dow, Ross M. Kedl, Von Samedi, Mary-Keara Boss, Sana D. Karam
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/56d3e7c7ade74d0a8371f2100dd57477
Autor:
Benjamin Van Court, Brooke Neupert, Diemmy Nguyen, Richard Ross, Michael W. Knitz, Sana D. Karam
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Animal experiments are often used to determine effects of drugs and other biological conditions on cancer progression, but poor accuracy and reproducibility of established tumor measurement methods make results unreliable. In orthotopic mous
Externí odkaz:
https://doaj.org/article/1013c7e44d2d4b2da433122e0aee93dd
Autor:
Benjamin Van Court, Jacob Gadwa, Diemmy Nguyen, Shiv Bhuvane, Thomas E. Bickett, Laurel L. Lenz, Shilpa Bhatia, Laurel B. Darragh, Ayman Oweida, Alexander L. Dent, Michael W. Knitz, Miles Piper, Andy Phan, Sana D. Karam, Tiffany T. Pham, Sophia Corbo
Publikováno v:
Mol Ther
STAT3 signaling has been shown to regulate cellular function and cytokine production in the tumor microenvironment (TME). Within the head and neck squamous cell carcinoma (HNSCC) TME, we previously showed that therapeutic targeting of STAT3 in combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a883b5f80a0b774060ff79a508868af
https://doi.org/10.1016/j.ymthe.2021.11.011
https://doi.org/10.1016/j.ymthe.2021.11.011
Autor:
Benjamin Van Court, Miles Piper, Sana D. Karam, Thomas E. Bickett, Laurel L. Lenz, Kevin Barry, Hua Tu, Shiv Bhuvane, Eric T. Clambey, Shilpa Bhatia, Diemmy Nguyen, Michael W. Knitz, Laurel B. Darragh, Jacob Gadwa
Publikováno v:
Clin Cancer Res
Purpose:Natural killer (NK) cells are type I innate lymphoid cells that are known for their role in killing virally infected cells or cancer cells through direct cytotoxicity. In addition to direct tumor cell killing, NK cells are known to play funda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a545b520cba8162239a129cfca9b150
https://doi.org/10.1158/1078-0432.ccr-21-0971
https://doi.org/10.1158/1078-0432.ccr-21-0971
Autor:
Laurel B. Darragh, Jacob Gadwa, Tiffany T. Pham, Benjamin Van Court, Brooke Neupert, Nicholas A. Olimpo, Khoa Nguyen, Diemmy Nguyen, Michael W. Knitz, Maureen Hoen, Sophia Corbo, Molishree Joshi, Yonghua Zhuang, Maria Amann, Xiao-Jing Wang, Steven Dow, Ross M. Kedl, Von Samedi, Mary-Keara Boss, Sana D. Karam
Publikováno v:
Nature communications, vol 13, iss 1
In the setting of conventional radiation therapy, even when combined with immunotherapy, head and neck cancer often recurs locally and regionally. Elective nodal irradiation (ENI) is commonly employed to decrease regional recurrence. Given our develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f192aac4b517f7a93d6d16bfb7bb3ec
https://escholarship.org/uc/item/2nm864pp
https://escholarship.org/uc/item/2nm864pp
Autor:
Yuwen Zhu, Marco Del Chiaro, Ross M. Kedl, Miles Piper, Maxwell Mayeda, Sana D. Karam, Jung Jae Lee, Thomas E. Bickett, Laurel L. Lenz, Michael W. Knitz, Richard D. Schulick, Shilpa Bhatia, Laurel B. Darragh, Alexander L. Dent, Shuichi Watanabe, Rustain Morgan, Adam C. Mueller, Diemmy Nguyen, Sophia Corbo, Karyn A. Goodman, Wells A. Messersmith, Jacob Gadwa, Benjamin Van Court
Publikováno v:
Clin Cancer Res
Purpose: Metastasis remains a major hurdle in treating aggressive malignancies such as pancreatic ductal adenocarcinoma (PDAC). Improving response to treatment, therefore, requires a more detailed characterization of the cellular populations involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf45f65f952d85a73dc52627f2028bc4
https://europepmc.org/articles/PMC8898296/
https://europepmc.org/articles/PMC8898296/
Autor:
Michael W. Knitz, Benjamin Van Court, Ayman Oweida, Ahmed Gilani, Laurel B. Darragh, Sana D. Karam, Diana M. Cittelly, Rajeev Vibhakar, Sujatha Venkataraman, Miles Piper, Adam C. Mueller, Sanjana Bukkapatnam, Thomas E. Bickett, Adam L. Green, Jacob Gadwa, Shilpa Bhatia, Diemmy Nguyen, Andy Phan
Publikováno v:
Mol Carcinog
The aggressive nature of glioblastoma multiforme (GBM) may be attributed to the dysregulation of pathways driving both proliferation and invasion. EphrinB2, a membrane-bound ligand for some of the Eph receptors, has emerged as a critical target regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3383c691e8143c6f1bf2704e280c836e
https://doi.org/10.1002/mc.23237
https://doi.org/10.1002/mc.23237
Autor:
Sanjana Bukkapatnam, Laurel B. Darragh, Diemmy Nguyen, Benjamin Van Court, Michael W. Knitz, Sophia Corbo, Jacob Gadwa, Miles Piper, Sana D. Karam, Ayman Oweida, Thomas E. Bickett, Shilpa Bhatia
Publikováno v:
Cancer Immunol Immunother
Resistance to radiation therapy (RT) remains an obstacle in HPV-negative head and neck squamous cell carcinomas (HNSCCs)-even with a combined RT-immunotherapy approach. Jak-Stat proteins have long been studied for both their immune regulatory role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea59e07cea1c92ef7bfe3acbfdb3bc6c
https://europepmc.org/articles/PMC9987617/
https://europepmc.org/articles/PMC9987617/
Autor:
Shilpa Bhatia, Diemmy Nguyen, Laurel B. Darragh, Benjamin Van Court, Jaspreet Sharma, Michael W. Knitz, Miles Piper, Sanjana Bukkapatnam, Jacob Gadwa, Thomas E. Bickett, Shiv Bhuvane, Sophia Corbo, Brian Wu, Yichien Lee, Mayumi Fujita, Molishree Joshi, Lynn E. Heasley, Robert L. Ferris, Olga Rodriguez, Christopher Albanese, Mohit Kapoor, Elena B. Pasquale, Sana D. Karam
Publikováno v:
Nature communications. 13(1)
Differential outcomes of EphB4-ephrinB2 signaling offers formidable challenge for the development of cancer therapeutics. Here, we interrogate the effects of targeting EphB4 and ephrinB2 in head and neck squamous cell carcinoma (HNSCC) and within its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2ae9c2545256e07c467dce52cd6679
https://pubmed.ncbi.nlm.nih.gov/35725568
https://pubmed.ncbi.nlm.nih.gov/35725568