Výsledky vyhledávání - "Michael W Knitz"

Akademický článek

Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)

Background Numerous trials combining radiation therapy (RT) and immunotherapy in head and neck squamous cell carcinoma (HNSCC) are failing. Using preclinical immune cold models of HNSCC resistant to RT-immune checkpoint inhibitors, we investigate the

Externí odkaz: https://doaj.org/article/cbf79a9cbfcd4744b19d4b8a1b088264

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Akademický článek

Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Abstract In the setting of conventional radiation therapy, even when combined with immunotherapy, head and neck cancer often recurs locally and regionally. Elective nodal irradiation (ENI) is commonly employed to decrease regional recurrence. Given o

Externí odkaz: https://doaj.org/article/003c3639bcd64b89a4b408dd9a3666ed

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Dichotomous effects of cellular expression of STAT3 on tumor growth of HNSCC

Autor: Benjamin Van Court, Jacob Gadwa, Diemmy Nguyen, Shiv Bhuvane, Thomas E. Bickett, Laurel L. Lenz, Shilpa Bhatia, Laurel B. Darragh, Ayman Oweida, Alexander L. Dent, Michael W. Knitz, Miles Piper, Andy Phan, Sana D. Karam, Tiffany T. Pham, Sophia Corbo

Publikováno v: Mol Ther

STAT3 signaling has been shown to regulate cellular function and cytokine production in the tumor microenvironment (TME). Within the head and neck squamous cell carcinoma (HNSCC) TME, we previously showed that therapeutic targeting of STAT3 in combin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a883b5f80a0b774060ff79a508868af
https://doi.org/10.1016/j.ymthe.2021.11.011

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FLT3L Release by Natural Killer Cells Enhances Response to Radioimmunotherapy in Preclinical Models of HNSCC

Autor: Benjamin Van Court, Miles Piper, Sana D. Karam, Thomas E. Bickett, Laurel L. Lenz, Kevin Barry, Hua Tu, Shiv Bhuvane, Eric T. Clambey, Shilpa Bhatia, Diemmy Nguyen, Michael W. Knitz, Laurel B. Darragh, Jacob Gadwa

Publikováno v: Clin Cancer Res

Purpose:Natural killer (NK) cells are type I innate lymphoid cells that are known for their role in killing virally infected cells or cancer cells through direct cytotoxicity. In addition to direct tumor cell killing, NK cells are known to play funda

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a545b520cba8162239a129cfca9b150
https://doi.org/10.1158/1078-0432.ccr-21-0971

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The effects of ephrinB2 signaling on proliferation and invasion in glioblastoma multiforme

Autor: Michael W. Knitz, Benjamin Van Court, Ayman Oweida, Ahmed Gilani, Laurel B. Darragh, Sana D. Karam, Diana M. Cittelly, Rajeev Vibhakar, Sujatha Venkataraman, Miles Piper, Adam C. Mueller, Sanjana Bukkapatnam, Thomas E. Bickett, Adam L. Green, Jacob Gadwa, Shilpa Bhatia, Diemmy Nguyen, Andy Phan

Publikováno v: Mol Carcinog

The aggressive nature of glioblastoma multiforme (GBM) may be attributed to the dysregulation of pathways driving both proliferation and invasion. EphrinB2, a membrane-bound ligand for some of the Eph receptors, has emerged as a critical target regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3383c691e8143c6f1bf2704e280c836e
https://doi.org/10.1002/mc.23237

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Loss of cancer cell STAT1 improves response to radiation therapy and promotes T cell activation in head and neck squamous cell carcinoma

Autor: Sanjana Bukkapatnam, Laurel B. Darragh, Diemmy Nguyen, Benjamin Van Court, Michael W. Knitz, Sophia Corbo, Jacob Gadwa, Miles Piper, Sana D. Karam, Ayman Oweida, Thomas E. Bickett, Shilpa Bhatia

Publikováno v: Cancer Immunol Immunother

Resistance to radiation therapy (RT) remains an obstacle in HPV-negative head and neck squamous cell carcinomas (HNSCCs)-even with a combined RT-immunotherapy approach. Jak-Stat proteins have long been studied for both their immune regulatory role in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea59e07cea1c92ef7bfe3acbfdb3bc6c
https://europepmc.org/articles/PMC9987617/

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EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment

Publikováno v: Nature communications. 13(1)

Differential outcomes of EphB4-ephrinB2 signaling offers formidable challenge for the development of cancer therapeutics. Here, we interrogate the effects of targeting EphB4 and ephrinB2 in head and neck squamous cell carcinoma (HNSCC) and within its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2ae9c2545256e07c467dce52cd6679
https://pubmed.ncbi.nlm.nih.gov/35725568

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Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer

Autor: Diemmy Nguyen, Shiv Bhuvane, Benjamin Van Court, Laurel B. Darragh, Miles Piper, Jacob Gadwa, Michael W. Knitz, Sana D. Karam, Emily K Kleczko, Raphael A. Nemenoff, Thomas E. Bickett, Shilpa Bhatia, Varuna Nangia

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Journal for Immunotherapy of Cancer

BackgroundResistance to therapy is a major problem in treating head and neck squamous cell carcinomas (HNSCC). Complement system inhibition has been shown to reduce tumor growth, metastasis, and therapeutic resistance in other tumor models, but has y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330536d3f0f34fd8e1286eba89acee3b
https://jitc.bmj.com/content/9/3/e002585.full

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