Zobrazeno 1 - 10
of 559
pro vyhledávání: '"Michael W, Parker"'
Autor:
Belamy B. Cheung, Ritu Mittra, Jayne Murray, Qian Wang, Janith A. Seneviratne, Mukesh Raipuria, Iris Poh Ling Wong, David Restuccia, Andrew Gifford, Alice Salib, Selina Sutton, Libby Huang, Parisa Vahidi Ferdowsi, Joanna Tsang, Eric Sekyere, Chelsea Mayoh, Lin Luo, Darren L. Brown, Jennifer L. Stow, Shizhen Zhu, Richard J. Young, Benjamin J. Solomon, Stephane Chappaz, Benjamin Kile, Andrew Kueh, Marco J. Herold, Douglas J. Hilton, Tao Liu, Murray D. Norris, Michelle Haber, Daniel R. Carter, Michael W. Parker, Glenn M. Marshall
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract MYCN amplification predicts poor prognosis in childhood neuroblastoma. To identify MYCN oncogenic signal dependencies we performed N-ethyl-N-nitrosourea (ENU) mutagenesis on the germline of neuroblastoma-prone TH-MYCN transgenic mice to gene
Externí odkaz:
https://doaj.org/article/7aab45a11a28499aa2b12d59ee58078b
Autor:
Hunter L. Abrahamsen, Tristan C. Sanford, Casie E. Collamore, Bronte A. Johnstone, Michael J. Coyne, Leonor García-Bayona, Michelle P. Christie, Jordan C. Evans, Allison J. Farrand, Katia Flores, Craig J. Morton, Michael W. Parker, Laurie E. Comstock, Rodney K. Tweten
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Cholesterol-dependent cytolysins (CDCs) comprise a large family of pore-forming toxins produced by Gram-positive bacteria, which are used to attack eukaryotic cells. Here, we functionally characterize a family of 2-component CDC-like (CDCL)
Externí odkaz:
https://doaj.org/article/fa81631103bf486aa966a456bbef1768
Autor:
Rhynelle S. Dmello, Michelle Palmieri, Pathum S. Thilakasiri, Larissa Doughty, Tracy L. Nero, Ashleigh R. Poh, Sarah Q. To, Erinna F. Lee, W. Douglas Fairlie, Lisa Mielke, Michael W. Parker, Ivan K. H. Poon, Eduard Batlle, Matthias Ernst, Ashwini L. Chand
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-13 (2024)
Abstract Excessive STAT3 signalling via gp130, the shared receptor subunit for IL-6 and IL-11, contributes to disease progression and poor survival outcomes in patients with colorectal cancer. Here, we provide evidence that bazedoxifene inhibits tumo
Externí odkaz:
https://doaj.org/article/edd38efeaa4746be83b35dd07210b0bf
Autor:
Riley D. Metcalfe, Eric Hanssen, Ka Yee Fung, Kaheina Aizel, Clara C. Kosasih, Courtney O. Zlatic, Larissa Doughty, Craig J. Morton, Andrew P. Leis, Michael W. Parker, Paul R. Gooley, Tracy L. Putoczki, Michael D. W. Griffin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Interleukin (IL-)11, an IL-6 family cytokine, has pivotal roles in autoimmune diseases, fibrotic complications, and solid cancers. Despite intense therapeutic targeting efforts, structural understanding of IL-11 signalling and mechanistic in
Externí odkaz:
https://doaj.org/article/57a7cb56921f49669d1a14d82f0a823a
Autor:
KM Rifat Faysal, James C Walsh, Nadine Renner, Chantal L Márquez, Vaibhav B Shah, Andrew J Tuckwell, Michelle P Christie, Michael W Parker, Stuart G Turville, Greg J Towers, Leo C James, David A Jacques, Till Böcking
Publikováno v:
eLife, Vol 13 (2024)
The HIV-1 capsid has emerged as a tractable target for antiretroviral therapy. Lenacapavir, developed by Gilead Sciences, is the first capsid-targeting drug approved for medical use. Here, we investigate the effect of lenacapavir on HIV capsid stabil
Externí odkaz:
https://doaj.org/article/08ba42401fe84baebde255dedc84b832
Autor:
Johannes Zeller, Karen S Cheung Tung Shing, Tracy L Nero, James D McFadyen, Guy Krippner, Balázs Bogner, Sheena Kreuzaler, Jurij Kiefer, Verena K Horner, David Braig, Habiba Danish, Sara Baratchi, Mark Fricke, Xiaowei Wang, Michel G Kather, Bernd Kammerer, Kevin J Woollard, Prerna Sharma, Craig J Morton, Geoffrey Pietersz, Michael W Parker, Karlheinz Peter, Steffen U Eisenhardt
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 1, Pp n/a-n/a (2023)
Abstract C‐reactive protein (CRP) is an early‐stage acute phase protein and highly upregulated in response to inflammatory reactions. We recently identified a novel mechanism that leads to a conformational change from the native, functionally rel
Externí odkaz:
https://doaj.org/article/8b881686a26748449e95ec090389d914
Autor:
Caroline Dix, Johannes Zeller, Hannah Stevens, Steffen U. Eisenhardt, Karen S. Cheung Tung Shing, Tracy L. Nero, Craig J. Morton, Michael W. Parker, Karlheinz Peter, James D. McFadyen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
C-reactive protein (CRP) is a member of the highly conserved pentraxin superfamily of proteins and is often used in clinical practice as a marker of infection and inflammation. There is now increasing evidence that CRP is not only a marker of inflamm
Externí odkaz:
https://doaj.org/article/c4240389338e43d6a34173ed2f3b2938
Autor:
Conall McGuinness, James C Walsh, Charles Bayly-Jones, Michelle A Dunstone, Michelle P Christie, Craig J Morton, Michael W Parker, Till Böcking
Publikováno v:
eLife, Vol 11 (2022)
The cholesterol-dependent cytolysin perfringolysin O (PFO) is secreted by Clostridium perfringens as a bacterial virulence factor able to form giant ring-shaped pores that perforate and ultimately lyse mammalian cell membranes. To resolve the kinetic
Externí odkaz:
https://doaj.org/article/9c52c20469604be898a9fcf4065fd2d3
Autor:
Zsuzsanna Nagy, Janith A. Seneviratne, Maxwell Kanikevich, William Chang, Chelsea Mayoh, Pooja Venkat, Yanhua Du, Cizhong Jiang, Alice Salib, Jessica Koach, Daniel R. Carter, Rituparna Mittra, Tao Liu, Michael W. Parker, Belamy B. Cheung, Glenn M. Marshall
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Neuroblastoma (NB) is often driven by MYCN amplification. Here, the authors show that the most frequent genetic lesion, gain of 17q21-ter in NB leads to overexpression of ALYREF, which forms a complex with MYCN, regulating MYCN stability via the deub
Externí odkaz:
https://doaj.org/article/9758c1cb40dc42078fa4de67f4245a4d
Autor:
Leo Yi Yang Lee, Randy Suryadinata, Conor McCafferty, Vera Ignjatovic, Damian F. J. Purcell, Phil Robinson, Craig J. Morton, Michael W. Parker, Gary P. Anderson, Paul Monagle, Kanta Subbarao, Jessica A. Neil
Publikováno v:
Viruses, Vol 14, Iss 12, p 2620 (2022)
SARS-CoV-2 is the causative agent of the COVID-19 pandemic. Vaccination, supported by social and public health measures, has proven efficacious for reducing disease severity and virus spread. However, the emergence of highly transmissible viral varia
Externí odkaz:
https://doaj.org/article/da5ad53583874626aa4cd8c4e288da7b