Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Michael Vrkljan"'
Autor:
Neil W. Gibson, Patricia Beck, Andrew Cooke, Feng-Lei Sun, Vanessa Smith, Michael Vrkljan, Mark Bittner, Mark J. Mulvihill, Anthony Nigro, David M. Keane, Arlindo L. Castelhano, Cara Cesario, Julie L.C. Kan, David L. Emerson, Shannon L. Winski, Mary Srebernak, Christy Nillson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1669-1673
A series of [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines were designed and synthesized as CYP26 inhibitors, serving as retinoic acid metabolic blocking agents (RAMBA's).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da526572c07626658dcb08c905b6d524
https://doi.org/10.1016/j.bmcl.2005.01.044
https://doi.org/10.1016/j.bmcl.2005.01.044
Autor:
Uday Narahari, Thomas M. Foster, Jeffrey D. Meyer, Jonathon J. Dormish, Michael Vrkljan, Mark C. Manning, William Porter, John F. Carpenter, Jack Henkin, Harold Staack
Publikováno v:
International Journal of Pharmaceutics. 134:193-201
A turbidimetric assay was used to determine the extent of thermally-induced aggregation in low molecular weight urokinase (LMW-UK). Previous work has shown that, under 60°C heat treatment, LMW-UK denatures and the unfolded protein proceeds to form s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ac5f63113f8dfce69703acee3e0caec
https://doi.org/10.1016/0378-5173(95)04442-6
https://doi.org/10.1016/0378-5173(95)04442-6
Autor:
John F. Carpenter, Michael Vrkljan, William Porter, Harold Staack, Jack Henkin, Thomas M. Foster, Michael E. Powers, Mark C. Manning
Publikováno v:
Pharmaceutical Research. 11:1004-1008
Turbidimetric or light scattering assays can be used to determine the extent of aggregation in protein formulations. Using low molecular weight urokinase (LMW-UK) as a model protein, the effect of polymeric additives on heat-induced aggregation was e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1e22865e5a361081a80b6ee52c833fd
https://doi.org/10.1023/a:1018935420680
https://doi.org/10.1023/a:1018935420680
Autor:
Jeffrey D. Meyer, Brent S. Kendrick, Michael Vrkljan, Jonathon J. Dormish, James E. Matsuura, John F. Carpenter, James R. Ruth, Mark C. Manning, Eli Sheftert
Publikováno v:
Biotechnology and bioengineering. 48(5)
Stabilization of proteins through proper formulation is an important challenge for the pharmaceutical industry. Two approaches for stabilization of proteins in solution are discussed. First, work describing the effect of additives on the thermally in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8cb26a2c7db2d357edcb9ac166bceed
https://pubmed.ncbi.nlm.nih.gov/18623515
https://pubmed.ncbi.nlm.nih.gov/18623515