Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Michael Vacher"'
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
BackgroundComplex disorders, such as Alzheimer’s disease (AD), result from the combined influence of multiple biological and environmental factors. The integration of high-throughput data from multiple omics platforms can provide system overviews,
Externí odkaz:
https://doaj.org/article/1733a2f5fca247f1a4c6a1c9f2a90e35
Autor:
Gemma Cadby, Corey Giles, Phillip E. Melton, Kevin Huynh, Natalie A. Mellett, Thy Duong, Anh Nguyen, Michelle Cinel, Alex Smith, Gavriel Olshansky, Tingting Wang, Marta Brozynska, Mike Inouye, Nina S. McCarthy, Amir Ariff, Joseph Hung, Jennie Hui, John Beilby, Marie-Pierre Dubé, Gerald F. Watts, Sonia Shah, Naomi R. Wray, Wei Ling Florence Lim, Pratishtha Chatterjee, Ian Martins, Simon M. Laws, Tenielle Porter, Michael Vacher, Ashley I. Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Kevin Taddei, Matthias Arnold, Gabi Kastenmüller, Kwangsik Nho, Andrew J. Saykin, Xianlin Han, Rima Kaddurah-Daouk, Ralph N. Martins, John Blangero, Peter J. Meikle, Eric K. Moses
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Dysregulation of lipid metabolism is associated with coronary artery disease (CAD). Here, the authors perform GWAS of the serum lipidome to identify variants associated with lipid species that are putatively in the mechanistic pathway to CAD.
Externí odkaz:
https://doaj.org/article/1160229aa3d04cc8a6b15b682b0f47a7
Autor:
Michael Vacher, Vincent Doré, Tenielle Porter, Lidija Milicic, Victor L. Villemagne, Pierrick Bourgeat, Sam C. Burnham, Timothy Cox, Colin L. Masters, Christopher C. Rowe, Jurgen Fripp, James D. Doecke, Simon M. Laws
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-8 (2022)
Abstract Background With a growing number of loci associated with late-onset (sporadic) Alzheimer’s disease (AD), the polygenic contribution to AD is now well established. The development of polygenic risk score approaches have shown promising resu
Externí odkaz:
https://doaj.org/article/922fd30cfa5d4aa2bb78f823a53ae0a8
Publikováno v:
Biomolecules, Vol 12, Iss 3, p 464 (2022)
Relapse after surgery for oral squamous cell carcinoma (OSCC) contributes significantly to morbidity, mortality and poor outcomes. The current histopathological diagnostic techniques are insufficiently sensitive for the detection of oral cancer and m
Externí odkaz:
https://doaj.org/article/0cbc5fb275f54a738500218909dd56a9
Publikováno v:
Journal of Alzheimer's Disease Reports. :1-29
Epigenetic mechanisms such as DNA methylation have been implicated in a number of diseases including cancer, heart disease, autoimmune disorders, and neurodegenerative diseases. While it is recognized that DNA methylation is tissue-specific, a limita
Autor:
Lidija, Milicic, Michael, Vacher, Tenielle, Porter, Vincent, Doré, Samantha C, Burnham, Pierrick, Bourgeat, Rosita, Shishegar, James, Doecke, Nicola J, Armstrong, Rick, Tankard, Paul, Maruff, Colin L, Masters, Christopher C, Rowe, Victor L, Villemagne, Simon M, Laws, David, Ames
Publikováno v:
GeroScience. 44:1807-1823
The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer’s Disease (AD). Whilst studies have reported associations wi
Autor:
Cai Gillis, Marcela Ines Cespedes, Nancy Nairi Maserejian, Vincent Dore, Paul Maruff, Christopher Fowler, Stephanie Rainey‐Smith, Victor L Villemagne, Christopher Rowe, Ralph N Martins, Michael Vacher, Colin L Masters, James D Doecke
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Ying Xia, Vincent Dore, Victor L. Villemagne, Brendan S. Silbert, Jurgen Fripp, James D. Doecke, Elise J Harrison, Adrian Kamer, Robert Grenfell, Madeline Peretti, Simon McBride, Christopher C. Rowe, Paul Maruff, Lidija Milicic, Kelly K. Pertile, Steven J. Collins, Tania Taddei, Christine Thai, Andrea G. Louey, Michael Weinborn, Richard Head, Pierrick Bourgeat, Colin L. Masters, Olivier Salvado, Sabine Bird, S. Lance Macaulay, Rebecca L. Rumble, Michael Vacher, Simon Gibson, Lucy Lim, Amir Fazlollahi, Samantha C. Burnham, Kathryn A. Ellis, Yen Ying Lim, Regan Tyrrell, Julia Bomke, Michael Woodward, Belinda M. Brown, Joanne Robertson, Brett Trounson, Simon M. Laws, Carolyn Chadunow, Magdalene Soh, Liang Jin, Morgan Radler, Greg Savage, Christopher Fowler, Ralph N. Martins, Samantha L. Gardener, Fiona Lamb, Mark Rodrigues, Lucy Mackintosh, David Ames, Stephanie R. Rainey-Smith, Lis Evered, Alan Rembach, Tenielle Porter, Qiao-Xin Li, Nicola T. Lautenschlager, Shiji Varghese, Ashley I. Bush, Hamid R. Sohrabi, Kevin Taddei
Publikováno v:
Journal of Alzheimer's Disease Reports
Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in 2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild cognitive impairment (MCI), and 211 with Alzheimer’s disease dementi
Autor:
Michael Vacher, Tenielle Porter, Lidija Milicic, Pierrick Bourgeat, Vincent Dore, Victor L Villemagne, Simon M. Laws, James D. Doecke
Publikováno v:
Journal of Alzheimer's disease : JAD. 86(4)
Background: The blood-brain barrier (BBB) is formed by a high-density lining of endothelial cells, providing a border between circulating blood and the brain interstitial fluid. This structure plays a key role in protecting the brain microenvironment
Autor:
Henning Lenz, Michael Vacher, Santana Royan, Charles S. Bond, Mareike Schallenberg-Rüdinger, Ian Small, Julian Tonti-Filippini, Volker Knoop, Bernard Gutmann, Ian Castleden, Rose McDowell
Publikováno v:
Molecular Plant. 13:215-230
The RNA-binding pentatricopeptide repeat (PPR) family comprises hundreds to thousands of genes in most plants, but only a few dozen in algae, indicating massive gene expansions during land plant evolution. The nature and timing of these expansions ha