Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Michael V. Wiles"'
Autor:
Thomas J. Sproule, Robert Y. Wilpan, John J. Wilson, Benjamin E. Low, Yudai Kabata, Tatsuo Ushiki, Riichiro Abe, Michael V. Wiles, Derry C. Roopenian, John P. Sundberg
Publikováno v:
PLoS ONE, Vol 18, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/bb36004a0e2244fc95afb205ce007495
Functional analysis of Collagen 17a1: A genetic modifier of junctional epidermolysis bullosa in mice
Autor:
Thomas J. Sproule, Robert Y. Wilpan, Benjamin E. Low, Kathleen A. Silva, Deepak Reyon, J. Keith Joung, Michael V. Wiles, Derry C. Roopenian, John P. Sundberg
Publikováno v:
PLoS ONE, Vol 18, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/b35e2867765f469386053944e0c11913
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The development of mouse models of human disease and synthetic biology research by targeted transgenesis of large DNA constructs represent a significant genetic engineering hurdle. We developed an efficient, precise, single-copy integration
Externí odkaz:
https://doaj.org/article/5f22cb85ab5f473c9c26982747cd84dc
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/3aa63b687fae4633a049c778577a87f7
Autor:
Jennifer K. Sargent, Mark A. Warner, Benjamin E. Low, William H. Schott, Todd Hoffert, David Coleman, Xing Yi Woo, Todd Sheridan, Sonia Erattupuzha, Philipp P. Henrich, Vivek M. Philip, Jeffrey H. Chuang, Michael V. Wiles, Muneer G. Hasham
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 9 (2022)
Externí odkaz:
https://doaj.org/article/cd0b8ed3add94265be8d44e04d45e0f5
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
The inability to insert large DNA constructs into the genome efficiently and precisely is a key challenge in genomic engineering. Random transgenesis, which is widely used, lacks precision, and comes with a slew of drawbacks. Lentiviral and adeno-ass
Externí odkaz:
https://doaj.org/article/646a1d7039ed4d209202d2d1ea981c43
Autor:
M. Heath Farris, Pamela A. Texter, Agustin A. Mora, Michael V. Wiles, Ellen F. Mac Garrigle, Sybil A. Klaus, Kristine Rosfjord
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-22 (2020)
Abstract Background The development and application of CRISPR technologies for the modification of the genome are rapidly expanding. Advances in the field describe new CRISPR components that are strategically engineered to improve the precision and r
Externí odkaz:
https://doaj.org/article/e65e94ab16aa42fb85f120ae284d11d6
Autor:
Vishnu Hosur, Benjamin E. Low, Daniel Li, Grace A. Stafford, Vivek Kohar, Leonard D. Shultz, Michael V. Wiles
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-25 (2020)
Abstract Background Gene disruption in mouse embryonic stem cells or zygotes is a conventional genetics approach to identify gene function in vivo. However, because different gene disruption strategies use different mechanisms to disrupt genes, the s
Externí odkaz:
https://doaj.org/article/4542729f114f4a1997e48e7b8d00f056
Autor:
Vishal Kumar Sarsani, Narayanan Raghupathy, Ian T. Fiddes, Joel Armstrong, Francoise Thibaud-Nissen, Oraya Zinder, Mohan Bolisetty, Kerstin Howe, Doug Hinerfeld, Xiaoan Ruan, Lucy Rowe, Mary Barter, Guruprasad Ananda, Benedict Paten, George M. Weinstock, Gary A. Churchill, Michael V. Wiles, Valerie A. Schneider, Anuj Srivastava, Laura G. Reinholdt
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 6, Pp 1795-1805 (2019)
Isogenic laboratory mouse strains enhance reproducibility because individual animals are genetically identical. For the most widely used isogenic strain, C57BL/6, there exists a wealth of genetic, phenotypic, and genomic data, including a high-qualit
Externí odkaz:
https://doaj.org/article/79024ff2960542d287e71077cee81570
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
A major asset of many monoclonal antibody (mAb)-based biologics is their persistence in circulation. The MHC class I family Fc receptor, FCGRT, is primarily responsible for this extended pharmacokinetic behavior. Engagement of FCGRT with the crystall
Externí odkaz:
https://doaj.org/article/5aa92fa88344437d8a2364087366b7cf