Výsledky vyhledávání - "Michael V. Sefton"

Akademický článek

Neutrophil depletion for early allogeneic islet survival in a methacrylic acid (MAA) copolymer-induced, vascularized subcutaneous space

Autor: So-Yoon Won, Sean M. Kinney, Michael V. Sefton

Publikováno v: Frontiers in Transplantation, Vol 2 (2023)

Islet transplantation is a promising treatment for type I diabetes (T1D). Despite the high loss of islets during transplantation, current islet transplant protocols continue to rely on portal vein infusion and intrahepatic engraftment. Because of the

Externí odkaz: https://doaj.org/article/fece0d8a39a14871aba0e8d7ddb947eb

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Presentation modality of glycoconjugates modulates dendritic cell phenotypeThis paper is dedicated to Professor Michael V. Sefton in honour of his 65th Birthday and in recognition of his mentorship, service and leadership to the Biomaterials community.Electronic supplementary information (ESI) available: The supplemental contains a more in-depth description of statistics and statistical models used. Three tables (Tables S1a, S1b and S2). Tables S1a and S1b describe variables used in the modeling of this report. Table S2 shows comparisons between all surface area ratios compared. Finally the supplemental contains two ESI figures. ESI Fig. S1 shows cell apoptosis in response to the conjugates. Fig. S2 shows cell phagocytosis of control coated beads. Fig. S3 shows representative MALDI spectra of the conjugates. See DOI: 10.1039/c4bm00138a

Autor: Hotaling, N. A., Ratner, D. M., Cummings, R. D., Babensee, J. E.

Publikováno v: Biomaterials Science; 2014, Vol. 2 Issue: 10 p1426-1439, 14p

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Pharmacokinetics and transgene expression of implanted polyethylenimine-based pDNA complexesWe dedicate this manuscript to Prof. Michael V. Sefton on the occasion of his 65th birthday. Prof. Sefton, with his independent spirit and unique insight, has been a guiding light in our scientific endeavours.Electronic supplementary information (ESI) available. See DOI: 10.1039/c3bm60200a

Autor: Rose, Laura, Mahdipoor, Parvin, Kucharski, Cezary, Uluda, Hasan

Publikováno v: Biomaterials Science; 2014, Vol. 2 Issue: 6 p833-842, 10p

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Methacrylic Acid-Based Regenerative Biomaterials: Explorations into the MAAgic

Autor: Alaura M. Androschuk, Miranda M. Carleton, Ilana Talior-Volodarsky, Michael V. Sefton

Publikováno v: Regenerative Engineering and Translational Medicine. 9:4-21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e38de3245823023027b8328cc979d97
https://doi.org/10.1007/s40883-022-00263-0

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Akademický článek

Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair

Autor: Sibel Naska, Scott A. Yuzwa, Adam P.W. Johnston, Smitha Paul, Kristen M. Smith, Maryline Paris, Michael V. Sefton, Alessandro Datti, Freda D. Miller, David R. Kaplan

Publikováno v: Stem Cell Reports, Vol 6, Iss 1, Pp 74-84 (2016)

Here, we asked whether we could identify pharmacological agents that enhance endogenous stem cell function to promote skin repair, focusing on skin-derived precursors (SKPs), a dermal precursor cell population. Libraries of compounds already used in

Externí odkaz: https://doaj.org/article/4cd59b2569bd494892c8e39f93f2704b

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Hearts by design

Autor: Michael V. Sefton, Craig A. Simmons

Publikováno v: Science

Helical alignments within the heart’s musculature have been speculated to be important in achieving physiological pumping efficiencies. Testing this possibility is difficult, however, because it is challenging to reproduce the fine spatial features

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9652aadb8dea40e7f9f1ffe18a8ab83
https://pubmed.ncbi.nlm.nih.gov/35857545

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Promoting endogenous repair of skeletal muscle using regenerative biomaterials

Autor: Michael V. Sefton, Miranda M. Carleton

Publikováno v: Journal of Biomedical Materials Research Part A. 109:2720-2739

Skeletal muscles normally have a remarkable ability to repair themselves; however, large muscle injuries and several myopathies diminish this ability leading to permanent loss of function. No clinical therapy yet exists that reliably restores muscle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec66c8f03445d3169a7f43b88b129b7
https://doi.org/10.1002/jbm.a.37239

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Methacrylic acid-based biomaterials promote peripheral innervation in the subcutaneous space of mice

Autor: Alaura M. Androschuk, Theresa H. Tam, Redouan Mahou, Cheun Lo, Michael W. Salter, Michael V. Sefton

Peripheral nerve innervation is essential for regulating tissue repair and regeneration. MAA-based biomaterials have been previously shown to promote angiogenesis. Here we show a new role for MAA-based biomaterials in promoting terminal axon nerve gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7b70f628bc31cc0883b585ee0fcab9
https://doi.org/10.1101/2022.04.03.486876

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Poly-Methacrylic Acid Cross-Linked with Collagen Accelerates Diabetic Wound Closure

Autor: Yangshuo Hu, Virginie F. Coindre, Michael V. Sefton

Publikováno v: ACS Biomaterials Science & Engineering. 6:6368-6377

Impaired blood vessel formation limits the healing of diabetic ulcers and leaves patients at high risk for amputation. Nonbiologic vascular regenerative materials made of methacrylic acid (MAA) copolymer, such as MAA-co-methyl methacrylate beads, hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc484452343152f12f4ad41e0299e091
https://doi.org/10.1021/acsbiomaterials.0c01222

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Bone Marrow-Derived Macrophages Enhance Vessel Stability in Modular Engineered Tissues

Autor: Elana Sefton, Michael E. D. West, Michael V. Sefton

Publikováno v: Tissue Engineering Part A. 25:911-923

Macrophages play a central role in the host response to tissue engineered constructs and their resultant vascularization. With a diversity of phenotypes, it is important to control the macrophage r...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ebdd9cbf8e83de8d7585f246f10a6b
https://doi.org/10.1089/ten.tea.2018.0222

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