Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Michael V. Miles"'
Autor:
G. A. Thompson, Eric Lawitz, Peter G. Traber, Arun J. Sanyal, Brent A. Neuschwander-Tetri, T. D. Schiano, N. Chalasani, Rohit Kohli, William Irish, Stephen A. Harrison, Michael V. Miles, W. Aronstein, Stavra A. Xanthakos, M.S. Siddiqui, S. R. Marri, Mazen Noureddin
Publikováno v:
Alimentary Pharmacology & Therapeutics. 44:1183-1198
SummaryBackground Non-alcoholic steatohepatitis (NASH) and resultant liver fibrosis is a major health problem without approved pharmacotherapy. Pre-clinical results of GR-MD-02, a galectin-3 inhibitor, suggested potential efficacy in NASH with advanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde13b6bb3fc10c035e867297682d21d
https://doi.org/10.1111/apt.13816
https://doi.org/10.1111/apt.13816
Publikováno v:
Epilepsia. 55:1415-1422
Summary Objectives Metabolic imaging studies, such as positron emission tomography (PET), allow for an assessment of physiologic functioning of the brain, and [18F]fluoro-2-deoxyglucose (FDG)–PET is now a commonly used technique in presurgical epil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5feb369aa12784ddaff142560af7e52c
https://doi.org/10.1111/epi.12731
https://doi.org/10.1111/epi.12731
Autor:
Francesco T. Mangano, Hansel M. Greiner, Lili Miles, Ki Hyeong Lee, Paul S. Horn, Michael V. Miles, Joo Hee Seo, James L. Leach
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 72:884-891
To identify pathologic characteristics that are associated with outcome, we performed a retrospective analysis of the clinical, radiologic, and pathologic features of 44 children with isolated focal cortical dysplasia (FCD) after epilepsy surgery. Ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb7c2e16c326d85a423cc7fcea3fff4
https://doi.org/10.1097/nen.0b013e3182a38d88
https://doi.org/10.1097/nen.0b013e3182a38d88
Publikováno v:
Human Pathology. 43:1249-1257
The purpose of this study was to evaluate relationships between subsarcolemmal mitochondrial aggregates and electron transport chain deficiencies in skeletal muscle with the objective of establishing an association between mitochondrial accumulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbde025b605bb02094249357bb8840c7
https://doi.org/10.1016/j.humpath.2011.09.016
https://doi.org/10.1016/j.humpath.2011.09.016
Publikováno v:
Biomedical Chromatography. 22:1403-1408
Previous studies have indicated that analysis of coenzyme Q10 (CoQ10) in platelets may be clinically useful. The study objectives are to describe, validate and provide application of an HPLC-EC method for platelet CoQ10 analysis. This method analyzes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29861f46367d43c4b3b9a14f28c6e0a
https://doi.org/10.1002/bmc.1072
https://doi.org/10.1002/bmc.1072
Autor:
Lili Miles, Antonius J. DeGrauw, Paul S. Horn, Brenda Wong, Michael V. Miles, Kevin E. Bove, Peter H. Tang, Paul Steele
Publikováno v:
Mitochondrion. 8:170-180
Coenzyme Q10 content, pathology evaluation, and electron transport chain (ETC) enzyme analysis were determined in muscle biopsy specimens of 82 children with suspected mitochondrial myopathy. Data were stratified into three groups: "probable" ETC def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbada233899af128d525ea3c703a1325
https://doi.org/10.1016/j.mito.2008.01.003
https://doi.org/10.1016/j.mito.2008.01.003
Coenzyme Q10 (Ubiquinol-10) Supplementation Improves Oxidative Imbalance in Children With Trisomy 21
Autor:
Michael V. Miles, Peter H. Tang, Melinda Chalfonte-Evans, Bonnie Patterson, Stephanie L. Hotze, Paul S. Horn, Francis Hickey, Paul Steele, Mark B. Schapiro
Publikováno v:
Pediatric Neurology. 37:398-403
Endogenous coenzyme Q10 is an essential cofactor in the mitochondrial respiratory chain, a potent antioxidant, and a potential biomarker for systemic oxidative status. Evidence of oxidative stress was reported in individuals with trisomy 21. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67bcbe00c5672418e9c6975a5da4a0f5
https://doi.org/10.1016/j.pediatrneurol.2007.08.003
https://doi.org/10.1016/j.pediatrneurol.2007.08.003
Autor:
James L. Leach, Paul S. Horn, Francesco T. Mangano, Hansel M. Greiner, Michael V. Miles, Lili Miles
Publikováno v:
Metabolic brain disease. 30(5)
It has been postulated that mitochondrial dysfunction may be an important factor in epileptogenesis of intractable epilepsy. The current study tests the hypothesis that mitochondrial Complex IV (CIV) or cytochrome c oxidase dysfunction is associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7736c25b35a16cae2940040f96fbc81c
https://pubmed.ncbi.nlm.nih.gov/25957585
https://pubmed.ncbi.nlm.nih.gov/25957585
Autor:
Michael V. Miles, Bonnie Patterson, Francis Hickey, Mark B. Schapiro, Paul S. Horn, Stephanie L. Hotze, Melinda Chalfonte-Evans
Publikováno v:
Pediatric Neurology. 35:30-37
Controlled studies of coenzyme Q(10) dosing and tolerance have been reported in adults, but not in pediatric patients. This study compares low- and high-dose coenzyme Q(10) (LiQ-NOL syrup) absorption and tolerance in children with Down syndrome. Afte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7408bfdaa2cb5fa9925ba08a1683c894
https://doi.org/10.1016/j.pediatrneurol.2005.11.004
https://doi.org/10.1016/j.pediatrneurol.2005.11.004
Autor:
Michael V. Miles, Peter H. Tang, Alexandra Wenisch, Lili Miles, John G. Quinlan, Kevin E. Bove, Brenda Wong, Paul S. Horn
Publikováno v:
Clinica Chimica Acta. 360:87-96
Background Coenzyme Q (CoQ) has been suggested as a biomarker for tissue redox status. The aims are (1) to compare ubiquinol-9, ubiquinol-10, ubiquinone-9, ubiquinone-10, total CoQ content and CoQ redox ratio in quadriceps muscle, heart, brain and li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea661ae7fca32bcdd8b517f231bfaaf0
https://doi.org/10.1016/j.cccn.2005.04.009
https://doi.org/10.1016/j.cccn.2005.04.009