Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Michael V. Darby"'
Autor:
Robert W. Brueggemeier, Dwitiya B. Sawant, Yasuro Sugimoto, Somsundaram Chettiar, Michael V. Darby, Pui-Kai Li, Chenglong Li, Harold A. Fisk, Liguang Mao
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2156-2166
New targeted therapy approaches for certain subtypes of breast cancer, such as triple-negative breast cancers and other aggressive phenotypes, are desired. High levels of the mitotic checkpoint kinase Mps1/TTK have correlated with high histologic gra
Autor:
Hitesh K. Agarwal, Elena Sjuvarsson, Michael V. Darby, Werner Tjarks, Staffan Eriksson, Craig A. McElroy
Publikováno v:
European Journal of Medicinal Chemistry. 60:456-468
Four different libraries of overall twenty three N3-substituted thymidine (dThd) analogues, including eleven 3-carboranyl thymidine analogues (3CTAs), were synthesized. The latter are potential agents for Boron Neutron Capture Therapy (BNCT) of cance
Autor:
Sherifa Hasabelnaby, Youngjoo Byun, Michael V. Darby, Judith C. Gallucci, Werner Tjarks, Rolf F. Barth, Ayman Goudah, Antonio Toppino, Robert A. Baiocchi, Tianyao Huo, Hitesh K. Agarwal, Ahmed Khalil, Rohit Tiwari
Publikováno v:
Inorganic Chemistry. 51:629-639
The synthesis and initial biological evaluation of 3-carboranylthymidine analogues (3CTAs) that are (radio)halogenated at the closo-carborane cluster are described. Radiohalogenated 3CTAs have the potential to be used in the radiotherapy and imaging
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 118:207-210
Aromatase is a particularly attractive drug target in the treatment of hormone-responsive breast cancer, and aromatase activity in breast cancer patients is greater in or near the tumor tissue compared with the normal breast tissue. Complex regulatio
Publikováno v:
Journal of Combinatorial Chemistry. 10:475-483
Combinatorial chemistry approaches facilitate drug discovery processes and result in structural modifications of lead compounds that enhance pharmacological activity, improve pharmacokinetic properties, and/or reduce unwanted side effects. Epidemiolo
Publikováno v:
Journal of Medicinal Chemistry. 51:1126-1135
Aromatase converts androgens to estrogens and is a particularly attractive target in the treatment of estrogen receptor positive breast cancer. Previously, the COX-2 selective inhibitor nimesulide and analogs decreased aromatase expression and enzyme
Publikováno v:
Biochemical and Biophysical Research Communications. 363:229-234
Small-molecule inhibitors of tau fibrillization are under investigation as tools for interrogating the tau aggregation pathway and as potential therapeutic agents for Alzheimer's disease. Established inhibitors include thiacarbocyanine dyes, which ca
Autor:
Michael V. Darby, Anne L. Quinn, Carl J. Lovely, Xin Ju Gu, David C. Baker, Jill M. O'Reilly, Nancy E. Gilbert, Patrick J Ward, Robert W. Brueggemeier
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 61:247-254
The inhibition of aromatase, the enzyme responsible for converting androgens to estrogens, is therapeutically useful for the endocrine treatment of hormone-dependent breast cancer. Research by our laboratory has focused on developing competitive and
Autor:
Robert W. Brueggemeier, Yasuro Sugimoto, Hong Li, Yu Zheng, Longzhu Piao, Yicheng Mao, Bo Yu, Robert J. Lee, Wanlop Weecharangsan, L. James Lee, Michael V. Darby, Xiaojuan Yang, Songlin Xu, Rumiana Koynova
Transferrin (Tf)-conjugated lipid-coated poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles carrying the aromatase inhibitor, 7alpha-(4'-amino)phenylthio-1,4-androstadiene-3,17-dione (7alpha-APTADD), were synthesized by a solvent injection method. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65e927244802873b321a34687ebd4ce
https://europepmc.org/articles/PMC3807850/
https://europepmc.org/articles/PMC3807850/
Autor:
Jun, Yang, Zengru, Wu, Di, Wu, Michael V, Darby, Seoung Soo, Hong, Duane D, Miller, James T, Dalton
Publikováno v:
International journal of oncology. 36(1)
Knowledge of the presence and extent of disease plays a major role in clinical management of prostate cancer, as it provides meaningful information as to which therapy to choose and who might benefit from this therapy. The wide expression of androgen