Kinetics and MR-Based Monitoring of AAV9 Vector Delivery into Cerebrospinal Fluid of Nonhuman Primates

Autor: Kousaku Ohno, Lluis Samaranch, Piotr Hadaczek, John R. Bringas, Philip C. Allen, Vivek Sudhakar, Diane E. Stockinger, Christopher Snieckus, Michael V. Campagna, Waldy San Sebastian, Jerusha Naidoo, Haifeng Chen, John Forsayeth, Ernesto A. Salegio, Granger G.C. Hwa, Krystof S. Bankiewicz

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 47-54 (2019)

Here we evaluated the utility of MRI to monitor intrathecal infusions in nonhuman primates. Adeno-associated virus (AAV) spiked with gadoteridol, a gadolinium-based MRI contrast agent, enabled real-time visualization of infusions delivered either via

Externí odkaz: https://doaj.org/article/5a819b72674d4e9490c437bdab03d8bd

Targeted Delivery and Tolerability of MRI-Guided CED Infusion into the Cerebellum of Nonhuman Primates

Autor: Ernesto A. Salegio, Michael V. Campagna, Granger G.C. Hwa, Diane E. Stockinger, Philip C. Allen, Yuanquan Song

Publikováno v: Human gene therapy methods. 29(4)

This study explored the feasibility of intraparenchymal delivery (gadoteridol and/or Serotype 5 Adeno-Associated Viral Vector-enhanced Green Fluorescent Protein [AAV5-eGFP]) into the cerebellum of nonhuman primates using real-time magnetic resonance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3849b9bf1feb67067c8517a7be17aa87
https://pubmed.ncbi.nlm.nih.gov/29953257

Contributors

Autor: Beverley Ann Alderton, Jonathan W. Ball, Alberto Rodriguez Barbon, Margaret Batchelder, Hugues Beaufrère, Michelle Bingley, Michael C. Blanco, Teresa Bradley Bays, Cynthia J. Brown, Anne Burgdorf-Moisuk, Michael V. Campagna, Michelle L. Campbell-Ward, Brendan Carmel, Cathy T.T. Chan, Jaime Chin, John Chitty, Deborah Cottrell, David A. Crum, Julie DeCubellis, Stephen J. Divers, Thomas M. Donnelly, Michael Dutton, Will Easson, David Eshar, Brian A. Evans, Peter G. Fischer, James G. Fox, Amy J. Funk, Alexis García, Jennifer Graham, Caroline Hahn, Katleen Hermans, Candace Hersey-Benner, Gretta Howard, Gwendolyn R. Jankowski, Emma Keeble, Dominique L. Keller, Peter Kerr, Sharron M. Kirchain, Megan Kirchgessner, La'Toya Latney, John Henry Lewington, Brad A. Lock, Rebecca L. Malakoff, Caralee Manley, Christoph Mans, Robert P. Marini, Jorge Martínez, Jörg Mayer, Anna Meredith, Huynh Minh, Mark A. Mitchell, Holly S. Mullen, Jason Norman, Brian S. Palmeiro, Jean A. Paré, Mary M. Patterson, David Perpiñán, Carrie A. Phelps, Charly Pignon, Anthony A. Pilny, Chantale L. Pinard, Romain Pizzi, Christal Pollock, Lauren V. Powers, Aidan Raftery, Viviane Silva Raymundo, Drury R. Reavill, Virgina C.G. Richardson, Cecilia Robat, Helen E. Roberts, William Rosenblad, David Sanchez-Migallon Guzman, Richard A. Saunders, Shannon N. Shaw, James L. (Jay) Shelton, Alana Shrubsole-Cockwill, Nico J. Schoemaker, Jeffrey Smith, Scott J. Stahl, Simon R. Starkey, W. Michael Taylor, Thomas N. Tully, Molly Varga, David Vella, Wolf von Bomhard, Narelle Walter, James F.X. Wellehan, Cameron J.G. Whittaker, Katherine E. Whitwell, Bruce H. Williams, Kimberlee B. Wojick, Kevin M. Wright, Nicole R. Wyre, Trevor T. Zachariah

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da1689d10fab6a9ead9d453439b3fff0
https://doi.org/10.1016/b978-1-4160-3969-3.00428-5