Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Michael V. Airola"'
Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation
Autor:
Yong Mi Choi, Dalila Ajjaji, Kaelin D. Fleming, Peter P. Borbat, Meredith L. Jenkins, Brandon E. Moeller, Shaveen Fernando, Surita R. Bhatia, Jack H. Freed, John E. Burke, Abdou Rachid Thiam, Michael V. Airola
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated proteins called perilipins (PLINs). During LD biogenesis, perilipin
Externí odkaz:
https://doaj.org/article/88d19ef3aa294ad58ab797d027080ed5
Autor:
Nivea Pereira de Sa, Kalani Jayanetti, Dominick Rendina, Timothy Clement, Veronica Soares Brauer, Caroline Mota Fernandes, Iwao Ojima, Michael V. Airola, Maurizio Del Poeta
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Invasive fungal infections are a leading cause of death in immunocompromised patients. Current therapies have several limitations, and innovative antifungal agents are critically needed. Previously, we identified the fungus-specific enzyme s
Externí odkaz:
https://doaj.org/article/10a62aeb5767483fa4514f5d67e00b54
Autor:
Nivea Pereira de Sa, Adam Taouil, Jinwoo Kim, Timothy Clement, Reece M. Hoffmann, John E. Burke, Robert C. Rizzo, Iwao Ojima, Maurizio Del Poeta, Michael V. Airola
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Sterylglucosidase 1 (Sgl1) is a virulence factor in Cryptococcus neoformans that modulates fungal pathogenesis and host response. Here, the authors characterize Sgl1 structurally, identify Sgl1 inhibitors, and demonstrate Sgl1 inhibition has efficacy
Externí odkaz:
https://doaj.org/article/b7ad82af9ed844d79dd8c233ece7e3ff
Autor:
Weijing Gu, Shujuan Gao, Huan Wang, Kaelin D. Fleming, Reece M. Hoffmann, Jong Won Yang, Nimi M. Patel, Yong Mi Choi, John E. Burke, Karen Reue, Michael V. Airola
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Lipins need to bind cell membranes before they can function as phosphatidic acid phosphatases. Here, the authors elucidate the structural basis of lipin membrane-association and identify a lipin domain with a novel protein fold that is critical for m
Externí odkaz:
https://doaj.org/article/3b33c35036634db9ae0d9e4f5089b84e
Autor:
Valerie I. Khayyo, Reece M. Hoffmann, Huan Wang, Justin A. Bell, John E. Burke, Karen Reue, Michael V. Airola
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Lipin/Pah phosphatidic acid phosphatases generate diacylglycerol to regulate triglyceride synthesis and cellular signaling. Here authors determine structures of Tetrahymena thermophila Pah2 and identify an N-terminal amphipathic helix essential for m
Externí odkaz:
https://doaj.org/article/e7dcb21670bd4693b4f6bcddbb95ec7f
Autor:
Jihui Ren, Justin Snider, Michael V. Airola, Aaron Zhong, Nadia A. Rana, Lina M. Obeid, Yusuf A. Hannun
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 1, Pp 162-170 (2018)
Serine palmitoyltransferase (SPT) catalyzes the rate-limiting step of condensation of L-serine and palmitoyl-CoA to form 3-ketodihydrosphingosine (3KDS). Here, we report a HPLC-ESI-MS/MS method to directly quantify 3KDS generated by SPT. With this te
Externí odkaz:
https://doaj.org/article/5b938cc4aebb4269bf430a0899eb3290
Autor:
Valerie I. Khayyo, Reece M. Hoffmann, Huan Wang, Justin A. Bell, John E. Burke, Karen Reue, Michael V. Airola
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/90b221a0204e431f85c2fe2324110a3d
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0271540 (2022)
Human alkaline ceramidase 3 (ACER3) is one of three alkaline ceramidases (ACERs) that catalyze the conversion of ceramide to sphingosine. ACERs are members of the CREST superfamily of integral-membrane hydrolases. All CREST members conserve a set of
Externí odkaz:
https://doaj.org/article/7139b7e45a5f40da98594db007c6de6e
Autor:
Maurizio Del Poeta, Michael V. Airola, Jinwoo Kim, Timothy Clement, Reece M. Hoffmann, Robert C. Rizzo, John E. Burke, Iwao Ojima, Adam Taouil, Nivea Pereira de Sa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Pathogenic fungi exhibit a heavy burden on medical care and new therapies are needed. Here, we develop the fungal specific enzyme sterylglucosidase 1 (Sgl1) as a therapeutic target. Sgl1 converts the immunomodulatory glycolipid ergosterol 3β-D-gluco
Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation
Autor:
Yong Mi Choi, Dalila Ajjaji, Kaelin D. Fleming, Peter P. Borbat, Meredith L. Jenkins, Brandon E. Moeller, Shaveen Fernando, Surita R. Bhatia, Jack H. Freed, John E. Burke, Abdou Rachid Thiam, Michael V. Airola
Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated proteins called perilipins (PLINs). During LD biogenesis, perilipin 3 (PLIN3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ab694a4005bdbc94cab2b3f2a6bf6db
https://doi.org/10.1101/2022.11.17.516819
https://doi.org/10.1101/2022.11.17.516819