Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Michael V Rothberg"'
Autor:
Jasper E. Neggers, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Annan Yang, Radha L. Kalekar, John M. Krill-Burger, Neekesh V. Dharia, Guillaume Kugener, Jérémie Kalfon, Chen Yuan, Nancy Dumont, Alfredo Gonzalez, Mai Abdusamad, Yvonne Y. Li, Liam F. Spurr, Westley W. Wu, Adam D. Durbin, Brian M. Wolpin, Federica Piccioni, David E. Root, Jesse S. Boehm, Andrew D. Cherniack, Aviad Tsherniak, Andrew L. Hong, William C. Hahn, Kimberly Stegmaier, Todd R. Golub, Francisca Vazquez, Andrew J. Aguirre
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109367- (2021)
Externí odkaz:
https://doaj.org/article/ac506d36e0fc45f58afd5108c6469b14
Autor:
Jasper E. Neggers, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Annan Yang, Radha L. Kalekar, John M. Krill-Burger, Neekesh V. Dharia, Guillaume Kugener, Jérémie Kalfon, Chen Yuan, Nancy Dumont, Alfredo Gonzalez, Mai Abdusamad, Yvonne Y. Li, Liam F. Spurr, Westley W. Wu, Adam D. Durbin, Brian M. Wolpin, Federica Piccioni, David E. Root, Jesse S. Boehm, Andrew D. Cherniack, Aviad Tsherniak, Andrew L. Hong, William C. Hahn, Kimberly Stegmaier, Todd R. Golub, Francisca Vazquez, Andrew J. Aguirre
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108493- (2020)
Summary: Few therapies target the loss of tumor suppressor genes in cancer. We examine CRISPR-SpCas9 and RNA-interference loss-of-function screens to identify new therapeutic targets associated with genomic loss of tumor suppressor genes. The endosom
Externí odkaz:
https://doaj.org/article/8d45f5f857914e55852e4f26974a4071
Autor:
Kimberly Stegmaier, Francisca Vazquez, Todd R. Golub, David E. Root, Scott T. Younger, Joseph D. Mancias, Volker Hovestadt, Nancy Dumont, Brenton R. Paolella, Joshua M. Dempster, Amy Saur Conway, Amanda L. Robichaud, Miljan Kuljanin, Alfredo Gonzalez, Mai Abdusamad, Michael V. Rothberg, Alexandra B. Forman, Guillaume Kugener, Neekesh V. Dharia, Clare F. Malone
NXT1 is a selective and lethal dependency in neuroblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c007b460f4affa6e191fd02da49f312
https://doi.org/10.1158/2159-8290.22539461
https://doi.org/10.1158/2159-8290.22539461
Autor:
Kimberly Stegmaier, Francisca Vazquez, Todd R. Golub, David E. Root, Scott T. Younger, Joseph D. Mancias, Volker Hovestadt, Nancy Dumont, Brenton R. Paolella, Joshua M. Dempster, Amy Saur Conway, Amanda L. Robichaud, Miljan Kuljanin, Alfredo Gonzalez, Mai Abdusamad, Michael V. Rothberg, Alexandra B. Forman, Guillaume Kugener, Neekesh V. Dharia, Clare F. Malone
CRISPR guide sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f5c15a72ce13e9594b29f8a9df403d
https://doi.org/10.1158/2159-8290.22539446.v1
https://doi.org/10.1158/2159-8290.22539446.v1
Autor:
Kimberly Stegmaier, Francisca Vazquez, Todd R. Golub, David E. Root, Scott T. Younger, Joseph D. Mancias, Volker Hovestadt, Nancy Dumont, Brenton R. Paolella, Joshua M. Dempster, Amy Saur Conway, Amanda L. Robichaud, Miljan Kuljanin, Alfredo Gonzalez, Mai Abdusamad, Michael V. Rothberg, Alexandra B. Forman, Guillaume Kugener, Neekesh V. Dharia, Clare F. Malone
Cancer dependency maps, which use CRISPR/Cas9 depletion screens to profile the landscape of genetic dependencies in hundreds of cancer cell lines, have identified context-specific dependencies that could be therapeutically exploited. An ideal therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c0222ac2a2c6c22d60bba9034ffb48f
https://doi.org/10.1158/2159-8290.c.6549098.v1
https://doi.org/10.1158/2159-8290.c.6549098.v1
Autor:
Daniel P. Bondeson, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Carly Langan, Gabriel Mesa, Alfredo Gonzalez, Lauren E. Surface, Kentaro Ito, Mariya Kazachkova, William N. Colgan, Allison Warren, Joshua M. Dempster, John M. Krill-Burger, Maria Ericsson, Andrew A. Tang, Iris Fung, Emily S. Chambers, Mai Abdusamad, Nancy Dumont, John G. Doench, Federica Piccioni, David E. Root, Jesse Boehm, William C. Hahn, Michael Mannstadt, James M. McFarland, Francisca Vazquez, Todd R. Golub
Publikováno v:
Nature Cancer. 3:681-695
Despite advances in precision medicine, the clinical prospects for patients with ovarian and uterine cancers have not substantially improved. Here, we analyzed genome-scale CRISPR-Cas9 loss-of-function screens across 851 human cancer cell lines and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b13e208ef750cd5c03e21c08b68dab3
https://doi.org/10.1038/s43018-022-00360-7
https://doi.org/10.1038/s43018-022-00360-7
Autor:
Syed S Mahmood, Peter A Riedell, Stephanie Feldman, Gina George, Stephen A Sansoterra, Thomas Althaus, Mahin Rehman, Elena Mead, Jennifer E Liu, Richard B Devereux, Jonathan W Weinsaft, Jiwon Kim, Lauren Balkan, Tarek Barbar, Katherine Lee Chuy, Bhisham Harchandani, Miguel-Angel Perales, Mark B Geyer, Jae H Park, M Lia Palomba, Roni Shouval, Ana A Tomas, Gunjan L Shah, Eric H Yang, Daria L Gaut, Michael V Rothberg, Evelyn M Horn, John P Leonard, Koen Van Besien, Matthew J Frigault, Zhengming Chen, Bhoomi Mehrotra, Tomas G Neilan, Richard M Steingart
Publikováno v:
European Heart Journal.
Aims Chimeric antigen receptor T-cell therapy (CAR-T) harnesses a patient’s immune system to target cancer. There are sparse existing data characterizing death outcomes after CAR-T-related cardiotoxicity. This study examines the association between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0c52fc1ea53b14c6fb6e335d513734
https://doi.org/10.1093/eurheartj/ehad117
https://doi.org/10.1093/eurheartj/ehad117
Autor:
Joshua M. Dempster, Neekesh V. Dharia, Mai Abdusamad, David E. Root, Volker Hovestadt, Francisca Vazquez, Kimberly Stegmaier, Clare F. Malone, Amanda L. Robichaud, Amy Saur Conway, Alfredo Gonzalez, Todd R. Golub, Alexandra B. Forman, Joseph D. Mancias, Guillaume Kugener, Brenton R. Paolella, Miljan Kuljanin, Michael V. Rothberg, Scott T. Younger, Nancy Dumont
Publikováno v:
Cancer Discovery. 11:2282-2299
Cancer dependency maps, which use CRISPR/Cas9 depletion screens to profile the landscape of genetic dependencies in hundreds of cancer cell lines, have identified context-specific dependencies that could be therapeutically exploited. An ideal therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1eb356ec5e51a8a9178454cbf707bc
https://doi.org/10.1158/2159-8290.cd-20-1213
https://doi.org/10.1158/2159-8290.cd-20-1213
Autor:
Radha L. Kalekar, Francisca Vazquez, Jesse S. Boehm, Thomas A. Skipper, Andrew J. Aguirre, Andrew L. Hong, Chen Yuan, Todd R. Golub, Guillaume Kugener, Westley W. Wu, Kimberly Stegmaier, Adam D. Durbin, Nancy Dumont, Michael V. Rothberg, Jasper E. Neggers, David E. Root, Neekesh V. Dharia, Mai Abdusamad, Andrew D. Cherniack, Adhana Asfaw, Brian M. Wolpin, Jeremie Kalfon, Liam F. Spurr, Brenton R. Paolella, Alfredo Gonzalez, William C. Hahn, Aviad Tsherniak, John M. Krill-Burger, Federica Piccioni, Annan Yang, Yvonne Y. Li
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108493-(2020)
Cell reports
Cell Reports, Vol 36, Iss 2, Pp 109367-(2021)
Cell reports
Cell Reports, Vol 36, Iss 2, Pp 109367-(2021)
SUMMARY Few therapies target the loss of tumor suppressor genes in cancer. We examine CRISPR-SpCas9 and RNA-interference loss-of-function screens to identify new therapeutic targets associated with genomic loss of tumor suppressor genes. The endosoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a207b62c9fbaf84df26f5e3aeb7c669
http://www.sciencedirect.com/science/article/pii/S2211124720314820
http://www.sciencedirect.com/science/article/pii/S2211124720314820
Autor:
William Colgan, Itay Tirosh, Emily Chambers, Andrew Jones, James M. McFarland, Jennifer Roth, Aviad Tsherniak, Michael V. Rothberg, Samantha Bender, Todd R. Golub, Kathryn Geiger-Schuller, Francisca Vazquez, Mahmoud Ghandi, Andrew J. Aguirre, Allison Warren, Olena Kuksenko, Aviv Regev, Orit Rozenblatt-Rosen, Brenton R. Paolella, Danielle Dionne, Tsukasa Shibue, Brian M. Wolpin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Assays to study cancer cell responses to pharmacologic or genetic perturbations are typically restricted to using simple phenotypic readouts such as proliferation rate. Information-rich assays, such as gene-expression profiling, have generally not pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec36ee579d1fcfd5173d20cdf8331e0
https://doi.org/10.1038/s41467-020-17440-w
https://doi.org/10.1038/s41467-020-17440-w