Výsledky vyhledávání - "Michael V Rector"

Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction

Autor: Wenjie Yu, Thomas O. Moninger, Michael V. Rector, David A. Stoltz, Michael J. Welsh

Publikováno v: Developmental cell. 57(18)

Pulmonary neuroendocrine cells (PNECs) are rare airway cells with potential sensory capacity linked to vagal neurons and immune cells. How PNECs sense and respond to external stimuli remains poorly understood. We discovered PNECs located within pig a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb1cb0c9c6f3aee66a5e897a3f9fd66
https://pubmed.ncbi.nlm.nih.gov/36108628

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Akademický článek

Expression of human paraoxonase 1 decreases superoxide levels and alters bacterial colonization in the gut of Drosophila melanogaster.

Autor: Alejandro A Pezzulo, Emma E Hornick, Michael V Rector, Miriam Estin, Anna C Reisetter, Peter J Taft, Stephen C Butcher, A Brent Carter, J Robert Manak, David A Stoltz, Joseph Zabner

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e43777 (2012)

Paraoxonases (PON) are a family of proteins (PON1, 2 and 3) with multiple enzymatic activities. PON1 interferes with homoserine lactone-mediated quorum sensing in bacteria and with reactive oxygen species (ROS) in humans and mice. PON1 gene mutations

Externí odkaz: https://doaj.org/article/cef0308d5eca4bdf8db408f320867777

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CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia

Autor: Peter J. Taft, Michael V. Rector, Xiaopeng Li, Alejandro A. Pezzulo, Thomas O. Moninger, Nathan D. Rossen, Michael J. Welsh, David A. Stoltz, Alejandro P. Comellas, Philip H. Karp, Paul B. McCray, Nicholas D. Gansemer, Sarah E. Ernst, Joseph Zabner

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 303:L152-L160

A balance between alveolar liquid absorption and secretion is critical for maintaining optimal alveolar subphase liquid height and facilitating gas exchange in the alveolar space. However, the role of cystic fibrosis transmembrane regulator protein (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de178c7e442f5f8c1e4e4fb54724b970
https://doi.org/10.1152/ajplung.00116.2012

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Loss of Anion Transport without Increased Sodium Absorption Characterizes Newborn Porcine Cystic Fibrosis Airway Epithelia

Autor: David A. Stoltz, Michael V. Rector, Kathryn Chaloner, Philip H. Karp, Leah R. Reznikov, Jeng-Haur Chen, Alejandro A. Pezzulo, Sarah E. Ernst, Janice L. Launspach, Thomas O. Moninger, Michael J. Welsh, Joseph Zabner

Publikováno v: Cell. 143(6):911-923

Defective transepithelial electrolyte transport is thought to initiate cystic fibrosis (CF) lung disease. Yet, how loss of CFTR affects electrolyte transport remains uncertain. CFTR -/- pigs spontaneously develop lung disease resembling human CF. At

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed092b24195c045fe139e377d0f24cc5

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Loss of Cystic Fibrosis Transmembrane Conductance Regulator Function Produces Abnormalities in Tracheal Development in Neonatal Pigs and Young Children

Autor: Amanda R. Smith, Melissa J. Suter, Shyam Ramachandran, Eman Namati, David A. Stoltz, Guillermo J. Tearney, Alejandro A. Pezzulo, Geoffrey McLennan, Paul B. McCray, Simon C. Kao, Michael V. Rector, Michael J. Welsh, David K. Meyerholz, Joseph Zabner

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 182:1251-1261

Although airway abnormalities are common in patients with cystic fibrosis (CF), it is unknown whether they are all secondary to postnatal infection and inflammation, which characterize the disease.To learn whether loss of the cystic fibrosis transmem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f73ba695b7ec9e6bc1e5bd78cda5130
https://doi.org/10.1164/rccm.201004-0643oc

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Cystic Fibrosis Transmembrane Conductance Regulator in Sarcoplasmic Reticulum of Airway Smooth Muscle. Implications for Airway Contractility

Autor: Lynda S. Ostedgaard, Michael V. Rector, Drake C. Bouzek, Andrew S. Michalski, Y. S. Prakash, Chun Y. Seow, Leah R. Reznikov, Daniel P. Cook, Nicholas D. Gansemer, Xiaopeng Li, David K. Meyerholz, Michael A. Thompson, David A. Stoltz, Mallory R. Stroik, Mahmoud H. Abou Alaiwa, Ramaswamy Krishnan

Publikováno v: American journal of respiratory and critical care medicine. 193(4)

An asthma-like airway phenotype has been described in people with cystic fibrosis (CF). Whether these findings are directly caused by loss of CF transmembrane conductance regulator (CFTR) function or secondary to chronic airway infection and/or infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be1c4055a66ceaac2c577421384e597
https://pubmed.ncbi.nlm.nih.gov/26871669

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