Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michael V Morabito"'
Autor:
Michael V Morabito, Yann Ravussin, Bridget R Mueller, Alicja A Skowronski, Kazuhisa Watanabe, Kylie S Foo, Samuel X Lee, Anders Lehmann, Stephan Hjorth, Lori M Zeltser, Charles A LeDuc, Rudolph L Leibel
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0168226 (2017)
Diet-induced obesity (DIO) resulting from consumption of a high fat diet (HFD) attenuates normal neuronal responses to leptin and may contribute to the metabolic defense of an acquired higher body weight in humans; the molecular bases for the persist
Externí odkaz:
https://doaj.org/article/e03bbf78f86141cca32bc013562de4ed
Autor:
Uade B Olaghere Da Silva, Michael V Morabito, Clinton E Canal, David C Airey, Ronald B Emeson, Elaine Sanders-Bush
Publikováno v:
Frontiers in Neuroscience, Vol 4 (2010)
Transcripts encoding 5-HT2C receptors are modified posttranscriptionally by RNA editing, generating up to 24 protein isoforms. In recombinant cells, the fully edited isoform, 5-HT2C-VGV, exhibits blunted G-protein coupling and reduced constitutive ac
Externí odkaz:
https://doaj.org/article/ba24d819bba5466da6eb2677ee25a476
Autor:
Michael V. Morabito, Diego E. Berman, Remy T. Schneider, Yiying Zhang, Rudolph L. Leibel, Scott A. Small
Publikováno v:
Neurobiology of Disease, Vol 65, Iss , Pp 188-192 (2014)
Type 2 diabetes (T2D) is a major risk factor for late-onset Alzheimer's disease (AD). A variety of metabolic changes related to T2D (e.g. hyperinsulinemia, hyperglycemia, and elevated branched-chain amino acids) have been proposed as mechanistic link
Externí odkaz:
https://doaj.org/article/c3c10dfc217449f2a5a435e3c75ef1f8
Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader–Willi syndrome
Autor:
Michael V. Morabito, Atheir I. Abbas, Jennifer L. Hood, Robert A. Kesterson, Michelle M. Jacobs, David S. Kump, David L. Hachey, Bryan L. Roth, Ronald B. Emeson
Publikováno v:
Neurobiology of Disease, Vol 39, Iss 2, Pp 169-180 (2010)
RNA transcripts encoding the 2C-subtype of serotonin (5HT2C) receptor undergo up to five adenosine-to-inosine editing events to encode twenty-four protein isoforms. To examine the effects of altered 5HT2C editing in vivo, we generated mutant mice sol
Externí odkaz:
https://doaj.org/article/a3f569d7de2e4b4798f5df34f527274b
Autor:
Richard Rausch, Michael V. Morabito, Béatrice Dubern, Liheng Wang, Gabriela Hubner, Michael Rosenbaum, Lisa Cole Burnett, Daniel Paull, Jayne F. Martin Carli, Charles A. LeDuc, Dieter Egli, Matthew Zimmer, Sanaa Eddiry, Alicja A. Skowronski, Daniel J. Driscoll, Christine Poitou, Brynn Levy, Merlin G. Butler, Robert Day, Carlos R. Sulsona, Rudolph L. Leibel, Karine Clément, Jean Pierre Salles, Ilene Fennoy, Maithé Tauber
Publikováno v:
Journal of Clinical Investigation. 127:293-305
Prader-Willi syndrome (PWS) is caused by a loss of paternally expressed genes in an imprinted region of chromosome 15q. Among the canonical PWS phenotypes are hyperphagic obesity, central hypogonadism, and low growth hormone (GH). Rare microdeletions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd02a2e8871f3256c0c4f50e627141ea
https://doi.org/10.1172/jci88648
https://doi.org/10.1172/jci88648
Autor:
Michael V. Morabito, Gabriela Hubner, Lisa Cole Burnett, Charles A. LeDuc, Jayne F. Martin Carli, Rudolph L. Leibel
Publikováno v:
Human molecular genetics. 26(23)
Global neurodevelopmental delay is a prominent characteristic of individuals with Prader-Willi syndrome (PWS). The neuromolecular bases for these delays are unknown. We identified neuroanatomical changes in the brains of mice deficient for a gene in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab43af01a015972e53b246b308b815ab
https://pubmed.ncbi.nlm.nih.gov/28973544
https://pubmed.ncbi.nlm.nih.gov/28973544
Autor:
Bridget R. Mueller, Samuel X. Lee, Kylie S. Foo, Kazuhisa Watanabe, Yann Ravussin, Stephan Hjorth, Charles A. LeDuc, Alicja A. Skowronski, Lori M. Zeltser, Anders Lehmann, Michael V. Morabito, Rudolph L. Leibel
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0168226 (2017)
PLoS ONE, Vol 12, Iss 1, p e0168226 (2017)
Diet-induced obesity (DIO) resulting from consumption of a high fat diet (HFD) attenuates normal neuronal responses to leptin and may contribute to the metabolic defense of an acquired higher body weight in humans; the molecular bases for the persist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70dd06acc399da5d3e4955847ca805e
http://europepmc.org/articles/PMC5249166
http://europepmc.org/articles/PMC5249166
Autor:
Michael V. Morabito, Ronald B. Emeson, Charles R. Martinez, Jennifer L. Hood, James A. Gilbert, Elizabeth A. Ferrick, Gregory D. Ayers, James D. Chappell, Terence S. Dermody
Publikováno v:
Molecular and Cellular Neuroscience. 61:97-109
Transcripts encoding ADAR1, a double-stranded, RNA-specific adenosine deaminase involved in the adenosine-to-inosine (A-to-I) editing of mammalian RNAs, can be alternatively spliced to produce an interferon-inducible protein isoform (p150) that is up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4ce6727cdb46349a7b8f6c4a495d3c
https://doi.org/10.1016/j.mcn.2014.06.001
https://doi.org/10.1016/j.mcn.2014.06.001
Autor:
Charles A. LeDuc, Bridget R. Mueller, Stephan Hjorth, Yann Ravussin, Kazuhisa Watanabe, Samuel Lee, Rudolph L. Leibel, Michael Rosenbaum, Alicja A. Skowronski, Anders Lehmann, Michael V. Morabito, Lori M. Zeltser
Publikováno v:
Obesity. 22:1287-1295
Objective The physiology of the weight-reduced (WR) state suggests that pharmacologic agents affecting energy homeostasis may have greater efficacy in WR individuals. Our aim was to establish a protocol that allows for evaluation of efficacy of weigh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccd89c61a6f973af0fea99616af57c6b
https://doi.org/10.1002/oby.20678
https://doi.org/10.1002/oby.20678
Autor:
David C. Airey, Lily Wang, Ronald B. Emeson, Randi J. Ulbricht, Pengcheng Lu, Bing Zhang, Michael V. Morabito, Richard T. O’Neil
Publikováno v:
Molecular Pharmacology. 77:895-902
RNA editing is a post-transcriptional modification in which adenosine residues are converted to inosine (adenosine-to-inosine editing). Commonly used methodologies to quantify RNA editing levels involve either direct sequencing or pyrosequencing of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6392be957a8357584d98112c21df382d
https://doi.org/10.1124/mol.109.061903
https://doi.org/10.1124/mol.109.061903