Výsledky vyhledávání - "Michael U Musheev"

Akademický článek

NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress

Autor: Dandan Han, Lars Schomacher, Katrin M Schüle, Medhavi Mallick, Michael U Musheev, Emil Karaulanov, Laura Krebs, Annika von Seggern, Christof Niehrs

Publikováno v: eLife, Vol 8 (2019)

Base excision repair (BER) functions not only in the maintenance of genomic integrity but also in active DNA demethylation and epigenetic gene regulation. This dual role raises the question if phenotypic abnormalities resulting from deficiency of BER

Externí odkaz: https://doaj.org/article/bc4ad1438cc94abd8d81ba2802e6ceab

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Akademický článek

Mammalian N1-adenosine PARylation is a reversible DNA modification

Autor: Michael U. Musheev, Lars Schomacher, Amitava Basu, Dandan Han, Laura Krebs, Carola Scholz, Christof Niehrs

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Poly-ADP-ribosylation (PARylation) is a well-known posttranslational modification of proteins. Here the authors show that beyond proteins also mammalian single-stranded DNA is PARylated in vitro and in vivo.

Externí odkaz: https://doaj.org/article/7801bd41a0df4b28973c9b4b6ea84a97

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The origin of genomic N6-methyl-deoxyadenosine in mammalian cells

Autor: Laura Krebs, Anne Baumgärtner, Christof Niehrs, Michael U. Musheev

Publikováno v: Nature Chemical Biology. 16:630-634

The proposal that N6-methyl-deoxyadenosine (m6dA) acts as an epigenetic mark in mammals remains controversial. Using isotopic labeling coupled to ultrasensitive mass spectrometry, we confirm the presence of low-level m6dA in mammalian DNA. However, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c45ab1bf74b7825bb2579fd9164d5565
https://doi.org/10.1038/s41589-020-0504-2

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GADD45 promotes locus-specific DNA demethylation and 2C cycling in embryonic stem cells

Autor: Christof Niehrs, Tommaso Andreani, Manuel Leichsenring, Michael U. Musheev, Medhavi Mallick, Emil Karaulanov, Katrin M. Schüle, Viviana Vastolo

Publikováno v: Genes & Development. 33:782-798

Mouse embryonic stem cell (ESC) cultures contain a rare cell population of “2C-like” cells resembling two-cell embryos, the key stage of zygotic genome activation (ZGA). Little is known about positive regulators of the 2C-like state and two-cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2975130be7330701035d7b1b7b884968
https://doi.org/10.1101/gad.325696.119

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GADD45A binds R-loops and recruits TET1 to CpG island promoters

Autor: Emil Karaulanov, Philipp Trnka, Ingrid Grummt, Khelifa Arab, Andrea I. Schäfer, Michael U. Musheev, Christof Niehrs

Publikováno v: Nature genetics

R-loops are DNA-RNA hybrids enriched at CpG islands (CGIs) that can regulate chromatin states1-8. How R-loops are recognized and interpreted by specific epigenetic readers is unknown. Here we show that GADD45A (growth arrest and DNA damage protein 45

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58d426582fc5ebf7a849a8bb0339139
https://doi.org/10.1038/s41588-018-0306-6

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Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning

Autor: Jacob Haase, Christof Niehrs, Oliver Rausch, Antje Ostareck-Lederer, Mihika Pradhan, You Zhou, Dirk H. Ostareck, Kathi Zarnack, Cornelia Rücklé, Julian König, Michael U. Musheev, Peter Hoch-Kraft, Nadine Körtel, Dan Dominissini, F. X. Reymond Sutandy, Stefan Hüttelmaier, Anke Busch, Christoph Dieterich

Publikováno v: Nucleic Acids Research
Nucleic acids research : NAR 49(16), e92 (2021). doi:10.1093/nar/gkab485

Nucleic acids research : NAR 49(16), e92 (2021). doi:10.1093/nar/gkab485
Published by Oxford Univ. Press, Oxford

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fa69be8f0916546aa5dc6aae2e7101
https://pubmed.ncbi.nlm.nih.gov/34157120

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Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning

Autor: Dan Dominissini, Peter Hoch-Kraft, Stefan Hüttelmaier, You Zhou, Oliver Rausch, Christoph Dieterich, Jacob Haase, Dirk H. Ostareck, Cornelia Rücklé, Antje Ostareck-Lederer, Christof Niehrs, Michael U. Musheev, Julian König, Kathi Zarnack, F. X. Reymond Sutandy, Nadine Körtel, Mihika Pradhan, Anke Busch

N6-methyladenosine (m6A) is the most abundant internal RNA modification in eukaryotic mRNAs and influences many aspects of RNA processing. miCLIP (m6A individual-nucleotide resolution UV crosslinking and immunoprecipitation) is an antibody-based appr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa02c12e2b01eea965d9b60c9cc55f35
https://doi.org/10.1101/2020.12.20.423675

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The 18S ribosomal RNA m 6 A methyltransferase Mettl5 is required for normal walking behavior in Drosophila

Autor: Pablo Mier, Christof Niehrs, Ludivine Wacheul, Minh Anh Vu, Michael U. Musheev, Marc Graille, Mihika Pradhan, Jean-Yves Roignant, Miguel A. Andrade-Navarro, Mariangela Spagnuolo, Denis L. J. Lafontaine, Jessica Leismann

Publikováno v: EMBO Reports
EMBO Reports, EMBO Press, 2020, pp.e49443. ⟨10.15252/embr.201949443⟩
EMBO Rep
EMBO Reports, EMBO Press, 2020, 21 (7), pp.e49443. ⟨10.15252/embr.201949443⟩
EMBO reports, 21 (7

RNA modifications have recently emerged as an important layer of gene regulation. N6-methyladenosine (m6A) is the most prominent modification on eukaryotic messenger RNA and has also been found on noncoding RNA, including ribosomal and small nuclear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f065fc4f06e053fccad71289724593de
https://doi.org/10.15252/embr.201949443

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