Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Michael U, Shiloh"'
Autor:
Kathryn C. Rahlwes, Beatriz R.S. Dias, Priscila C. Campos, Samuel Alvarez-Arguedas, Michael U. Shiloh
Publikováno v:
Virulence, Vol 14, Iss 1 (2023)
ABSTRACT Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious disease with one of the highest morbidity and mortality rates worldwide. Leveraging its highly evolved repertoire of non-protein and protein virulence fac
Externí odkaz:
https://doaj.org/article/9b79781faf3e46ad93abb7640b0ff687
Autor:
Haaris S Khan, Vidhya R Nair, Cody R Ruhl, Samuel Alvarez-Arguedas, Jorge L Galvan Rendiz, Luis H Franco, Linzhang Huang, Philip W Shaul, Jiwoong Kim, Yang Xie, Ron B Mitchell, Michael U Shiloh
Publikováno v:
eLife, Vol 9 (2020)
Mycobacterium tuberculosis (Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. Here, we show that M cell tr
Externí odkaz:
https://doaj.org/article/d7ed44f0af13427d8e7d84d1abe3eaa6
Autor:
Priscila C. Campos, Danielle T. Cunha, Luiz P. Souza-Costa, Michael U. Shiloh, Luis H. Franco
Publikováno v:
Trends in Microbiology. 30:973-985
Infection with Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), remains a significant global epidemic. Host resistance to Mtb depends on both adaptive and innate immunity mechanisms, including development of antigen-speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d5a4b7586457304007533b32a9529a
https://doi.org/10.1016/j.tim.2022.03.010
https://doi.org/10.1016/j.tim.2022.03.010
Autor:
Chelsea E. Stamm, Breanna L. Pasko, Sujittra Chaisavaneeyakorn, Luis H. Franco, Vidhya R. Nair, Bethany A. Weigele, Neal M. Alto, Michael U. Shiloh
Publikováno v:
mSphere, Vol 4, Iss 3 (2019)
ABSTRACT Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is one of the most successful human pathogens. One reason for its success is that Mtb can reside within host macrophages, a cell type that normally functions to phagocyto
Externí odkaz:
https://doaj.org/article/159f05ea47384c9c90842d3b47c3a1cf
Autor:
Vidhya R. Nair, Luis H. Franco, Vineetha M. Zacharia, Haaris S. Khan, Chelsea E. Stamm, Wu You, Denise K. Marciano, Hideo Yagita, Beth Levine, Michael U. Shiloh
Publikováno v:
Cell Reports, Vol 16, Iss 5, Pp 1253-1258 (2016)
The prevailing paradigm is that tuberculosis infection is initiated when patrolling alveolar macrophages and dendritic cells within the terminal alveolus ingest inhaled Mycobacterium tuberculosis (Mtb). However, definitive data for this model are lac
Externí odkaz:
https://doaj.org/article/ad22e38945ad49b0a84e9a1b41892893
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185945 (2017)
Mycobacterium tuberculosis, the causative agent of tuberculosis, is a major cause of morbidity and mortality worldwide. However, an effective vaccine for M. tuberculosis is lacking. We panned a phage display library using monoclonal antibodies agains
Externí odkaz:
https://doaj.org/article/979f0396c7f54da5b4385290c763ce10
Publikováno v:
Annual review of physiology.
Coughing is a dynamic physiological process resulting from input of vagal sensory neurons innervating the airways and perceived airway irritation. Although cough serves to protect and clear the airways, it can also be exploited by respiratory pathoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cc52ade3845a3aa906f16d8a0cdc9c
https://pubmed.ncbi.nlm.nih.gov/36170660
https://pubmed.ncbi.nlm.nih.gov/36170660
Autor:
Josephine W. Thinwa, Zhongju Zou, Emily Parks, Salwa Sebti, Kelvin Hui, Yongjie Wei, Vibha Singh, Greg Urquhart, Jenna L. Jewell, Julie K. Pfeiffer, Beth Levine, Tiffany A. Reese, Michael U. Shiloh
Virophagy, the selective autophagosomal engulfment and degradation of viral components, is crucial for antiviral immunity. However, the mechanisms leading to viral antigen recognition and autophagy induction remain poorly understood. Here, we identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a14f446e39a5beb9926a75ec48ecd15
https://doi.org/10.1101/2022.09.20.508746
https://doi.org/10.1101/2022.09.20.508746
Publikováno v:
Autophagy.
Macroautophagy/autophagy is necessary for lifespan extension in multiple model organisms and autophagy dysfunction impacts age-related phenotypes and diseases. Introduction of an F121A mutation into the essential autophagy protein BECN1 constitutivel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5c6b531ec347798c46d7be0e2326fcc
https://pubmed.ncbi.nlm.nih.gov/35993269
https://pubmed.ncbi.nlm.nih.gov/35993269
Autophagy is necessary for lifespan extension in multiple model organisms and autophagy dysfunction impacts age-related phenotypes and diseases. Introduction of an F121A mutation into the essential autophagy protein BECN1 constitutively increases bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3df3d870aab4e03779c83e15deaaba45
https://doi.org/10.1101/2022.01.12.475960
https://doi.org/10.1101/2022.01.12.475960