Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Michael Tolar Martin"'
Autor:
Bernie O’Hare, Glynn D. Williams, Elie A. Tabet, Peng Liu, Matthew A. Toczko, Charles E. Wade, Neil R. Curtis, Michael Tolar Martin, Michel Journet, David C. Leitch, Charles A. Goss, Tony Shaw, Anna L. Dunn
Publikováno v:
Organometallics. 38:129-137
The iodination of 4-fluoro-2-(trifluoromethyl)benzonitrile via C–H lithiation and subsequent treatment with iodine under continuous flow conditions is described. Screening identified both LDA and PhLi as effective bases, giving the desired 3-iodo r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3d2eab15c627c2bc2aee4e4c317f3c4
https://doi.org/10.1021/acs.organomet.8b00538
https://doi.org/10.1021/acs.organomet.8b00538
Autor:
Boggs Sharon Davis, Matthew J. Sharp, Kristjan S. Gudmundsson, Michael Tolar Martin, Vassil I. Elitzin
Publikováno v:
Organic Process Research & Development. 13:781-785
An improved, scalable synthesis of the CXCR4 antagonist GSK812397 is described. This new route was recently scaled up in 50 L fixed equipment to afford 1.2 kg of drug substance in five steps with an overall yield of 20% and >99% chemical and enantiom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19a7d8b53e51228cdb290f9a64bc2e9d
https://doi.org/10.1021/op9000675
https://doi.org/10.1021/op9000675
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 19:297-327
Ziagen, (1S,cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]- 2-cyclopentene-1-methanol, was synthesized from (1S,4R)-azabicyclo[2.2.1]hept-5-en-3-one by efficient processes which bypass problematic steps in earlier routes. 2-Amino-4,6-dichloro-5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8cb4ca7ca450e3f6eaed39af9451144
https://doi.org/10.1080/15257770008033011
https://doi.org/10.1080/15257770008033011
Autor:
Craig S. Regitz, Eric E. Boros, Vicente Samano, John A. Ray, Paul L. Feldman, Cecilia S. Koble, Michael Tolar Martin, James B. Thompson, David Kendall Jung, Eric C. Bigham, Robert A. Mook
Publikováno v:
Organic Letters. 1:1993-1996
[formula: see text] The stereo- and regioselective synthesis of ultra-short-acting nondepolarizing neuromuscular blocker GW 0430 (5a) is described. Key steps involved the enantioselective transfer hydrogenation of imine 8 employing Noyori's catalyst,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb86af889e9e4887429827930208603
https://doi.org/10.1021/ol9911573
https://doi.org/10.1021/ol9911573
Publikováno v:
Tetrahedron Letters. 48:2555-2557
PMHS (polymethylhydrosiloxane) used in catalytic amounts has a remarkable ability to prevent catalyst poisoning by oxygen contamination during palladium catalyzed cyanation reactions. The procedure is applicable to a wide range of substrates and is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::706f63d4971ecef733db944f6a62dc6b
https://doi.org/10.1016/j.tetlet.2007.02.018
https://doi.org/10.1016/j.tetlet.2007.02.018
Publikováno v:
Tetrahedron Letters. 43:2145-2147
An efficient, safe one-pot synthesis of thioethers from aromatic sulfonyl chlorides and activated alcohols has been developed under non-aqueous conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adf68c71c9f31e08ce9a75f97ea15244
https://doi.org/10.1016/s0040-4039(02)00218-6
https://doi.org/10.1016/s0040-4039(02)00218-6
Publikováno v:
ChemInform. 31
Ziagen, (1S,cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]- 2-cyclopentene-1-methanol, was synthesized from (1S,4R)-azabicyclo[2.2.1]hept-5-en-3-one by efficient processes which bypass problematic steps in earlier routes. 2-Amino-4,6-dichloro-5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dde2397644ba45476f4f55226c603ed
https://doi.org/10.1002/chin.200029196
https://doi.org/10.1002/chin.200029196
Publikováno v:
ChemInform. 33
An efficient, safe one-pot synthesis of thioethers from aromatic sulfonyl chlorides and activated alcohols has been developed under non-aqueous conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf4b43bbf7e24f230c567f36ea2c7d6e
https://doi.org/10.1002/chin.200227118
https://doi.org/10.1002/chin.200227118
Publikováno v:
ChemInform. 38
PMHS (polymethylhydrosiloxane) used in catalytic amounts has a remarkable ability to prevent catalyst poisoning by oxygen contamination during palladium catalyzed cyanation reactions. The procedure is applicable to a wide range of substrates and is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7c8d60763b4ec850e257f028f0f8be5
https://doi.org/10.1002/chin.200729076
https://doi.org/10.1002/chin.200729076
Publikováno v:
ChemInform. 34
A highly efficient reaction between sterically and electronically diverse sulfonamides and carboxylic acid anhydrides to furnish monoacylated N-acylsulfonamides is described. This represents the first systematic disclosure of the scope of sulfuric ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d306d184488cedef356e9c6bea4f7ea0
https://doi.org/10.1002/chin.200341097
https://doi.org/10.1002/chin.200341097