Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Michael Tibshirani"'
Autor:
Andreas Hermann, Arun Pal, Heather D. Durham, Kyle St. Louis, Sandra Minotti, Mario Fernandez, Rachel Kuta, Josephine Nalbantoglu, Michael Tibshirani, Nancy Larochelle, Benoit J. Gentil
Publikováno v:
Cell Stress & Chaperones
Cell stress & chaperones 25(1), 173-191 (2020). doi:10.1007/s12192-019-01064-1
Cell stress & chaperones 25(1), 173-191 (2020). doi:10.1007/s12192-019-01064-1
Upregulation of heat shock proteins (HSPs) is an approach to treatment of neurodegenerative disorders with impaired proteostasis. Many neurons, including motor neurons affected in amyotrophic lateral sclerosis (ALS), are relatively resistant to stres
Autor:
Ekaterina Rogaeva, Julia Keith, Janice Robertson, Heather D. Durham, Benoit J. Gentil, Christine Marques, Beibei Zhao, Caroline Rouaux, Lorne Zinman, Sandra Minotti, Michael Tibshirani
Publikováno v:
Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2017, 26 (21), pp.4142-4152. ⟨10.1093/hmg/ddx301⟩
Human Molecular Genetics, 2017, 26 (21), pp.4142-4152. ⟨10.1093/hmg/ddx301⟩
Human Molecular Genetics, Oxford University Press (OUP), 2017, 26 (21), pp.4142-4152. ⟨10.1093/hmg/ddx301⟩
Human Molecular Genetics, 2017, 26 (21), pp.4142-4152. ⟨10.1093/hmg/ddx301⟩
International audience; Amyotrophic lateral sclerosis is a fatal neurodegenerative disease with paralysis resulting from dysfunction and loss of motor neurons. A common neuropathological finding is attrition of motor neuron dendrites, which make cent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131ff34cb0fcb1cd5c047a64d916b0e8
https://www.hal.inserm.fr/inserm-03375235/document
https://www.hal.inserm.fr/inserm-03375235/document
Publikováno v:
Cell and Tissue Research. 360:609-620
Neurons are extremely polarised cells in which the cytoskeleton, composed of microtubules, microfilaments and neurofilaments, plays a crucial role in maintaining structure and function. Neurofilaments, the 10-nm intermediate filaments of neurons, pro
Autor:
Michael J. Strong, Hongru Zhou, Sandra Minotti, Lawrence J. Hayward, Katie R. Mattina, Heather D. Durham, Wencheng Yang, Miranda L. Tradewell, Michael Tibshirani
Publikováno v:
Human Molecular Genetics. 24:773-786
Mutations in the RNA-binding protein FUS/TLS (FUS) have been linked to the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Although predominantly nuclear, this heterogenous nuclear ribonuclear protein (hnRNP) has multiple functions in
Autor:
Stéphane Richard, Zhenbao Yu, Michael Tibshirani, Marie-Chloé Boulanger, Miranda L. Tradewell, Heather D. Durham
Publikováno v:
Human molecular genetics. 21(1)
Mutations in FUS/TLS (fused in sarcoma/translated in liposarcoma) cause an inheritable form of amyotrophic lateral sclerosis (ALS6). In contrast to FUS(WT), which is concentrated in the nucleus, these mutants are abnormally distributed in the cytopla