Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Michael Teifel"'
Autor:
Daniel Moj, Nicola Ammer, Babette Aicher, Jan-Georg Wojtyniak, Thorsten Lehr, Michael Teifel, Herbert Sindermann, Hannah Britz, Nina Hanke
Zoptarelin doxorubicin is a fusion molecule of the chemotherapeutic doxorubicin and a luteinizing hormone-releasing hormone receptor (LHRHR) agonist, designed for drug targeting to LHRHR positive tumors. The aim of this study was to establish a physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c5e9a18956370d7aca5ee1061fd910
Autor:
Pascal Marchand, Matthias Gerlach, Irene Seipelt, Michael Teifel, Maud Antoine, Eckhard Günther, Tilmann Schuster, Babette Aicher
Publikováno v:
MedChemComm. 7:224-229
A novel family of disubstituted pyrido[3,4-b]pyrazine-based compounds was discovered as valuable series for the design of promising protein kinase inhibitors. SAR study allowed the identification of 4-(piperidin-1-yl)aniline moiety as pharmacophoric
Autor:
Babette Aicher, Eckhard Günther, Tilmann Schuster, Maud Antoine, Irene Seipelt, Marc Le Borgne, Julien Defaux, Michael Teifel, Pascal Marchand, Cédric Logé, Matthias Gerlach
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3748-3752
A novel series of (7-aryl-1,5-naphthyridin-2-yl)ureas was discovered as dual ERK2 and Aurora B kinases inhibitors. Several analogues were active at micromolar and submicromolar range against ERK2 and Aurora B, associated with very promising antiproli
Autor:
Tilmann Schuster, Maud Antoine, Irene Seipelt, Marc Le Borgne, Babette Aicher, Michael Teifel, Eckhard Günther, Pascal Marchand, Julien Defaux, Matthias Gerlach
Publikováno v:
ChemMedChem. 9:217-232
As part of our research projects to identify new chemical entities of biological interest, we developed a synthetic approach and the biological evaluation of (7-aryl-1,5-naphthyridin-4-yl)ureas as a novel class of Aurora kinase inhibitors for the tre
Autor:
Jean Martinez, Babette Aicher, Peter Schmidt, Jacky Marie, Jean-Louis Banères, Gilbert Müller, Sophie Mary, Anne-Laure Blayo, Didier Gagne, Séverine Denoyelle, Eckhard Günther, Mathieu Maingot, Michael Teifel, Céline M'Kadmi, Jean-Alain Fehrentz, Marjorie Damian, Pierre Sanchez
Publikováno v:
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2016, 26 (10), pp.2408-2412. ⟨10.1016/j.bmcl.2016.04.003⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2016, 26 (10), pp.2408-2412. ⟨10.1016/j.bmcl.2016.04.003⟩
Introducing a second chiral center on our previously described 1,2,4-triazole, allowed us to increase diversity and elongate the 'C-terminal part' of the molecule. Therefore, we were able to explore mimics of the substance P analogs described as inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2453d99aed9b729a5b8511691d7dca67
https://hal.archives-ouvertes.fr/hal-02871896
https://hal.archives-ouvertes.fr/hal-02871896
Publikováno v:
Cancer Research. 71:P3-18
Introduction: Overexpression of MAPK has been detected in 34 % of TNBC and has been found to be associated with anthracycline resistance (1). AEZS-131 is a highly selective orally active ERK1/2-inhibitor, which has shown in vivo activity (first in cl
Autor:
Marc Dellian, Sebastian Strieth, Alexander Berghaus, Claudia Nussbaum, Martin Fuhrmann, Uwe Michaelis, Martin E. Eichhorn, Michael Teifel
Publikováno v:
International Journal of Cancer. 122:452-460
Paclitaxel encapsulated in cationic liposomes (EndoTAG-1) significantly impairs tumor growth by a significant reduction of functional tumor microcirculation and induction of endothelial cell apoptosis. The aim of the study was to analyze whether plat
Autor:
Céline M'Kadmi, Peter Schmidt, Eckhard Günther, Anne-Laure Blayo, Mathieu Maingot, Michael Teifel, Jean Martinez, Gilbert Müller, Babette Aicher, Jean-Alain Fehrentz, Didier Gagne, Séverine Denoyelle
Publikováno v:
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2015, 25 (1), pp.20-24. ⟨10.1016/j.bmcl.2014.11.031⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2015, 25 (1), pp.20-24. ⟨10.1016/j.bmcl.2014.11.031⟩
International audience; Ghrelin receptor ligands based on a trisubstituted 1,2,4-triazole scaffold were recently synthesized and evaluated for their in vitro affinity for the GHS-R1a receptor and their biological activity. In this study, replacement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4361224b8765441c6dfbe5027681ad5e
https://hal.archives-ouvertes.fr/hal-01090274
https://hal.archives-ouvertes.fr/hal-01090274
Autor:
Martin E. Eichhorn, Brita Schulze, Michael Teifel, Sascha Pahernik, Birgitta Sauer, Marc Dellian, Kurt Naujoks, A. Werner, Senat Krasnici, Uwe Michaelis, Marcus Schmitt-Sody
Publikováno v:
International Journal of Cancer. 105:561-567
Recently, cationic liposomes have been shown to preferentially target the angiogenic endothelium of tumors. It was the aim of our study to investigate the influence of liposomal surface charge on the uptake and kinetics of liposomes into solid tumors
Autor:
Peter Petzelbauer, W. Umek, Uwe Michaelis, Michael Teifel, Kurt Naujoks, Georg Wickenhauser, Klaus Wolff, Rainer Kunstfeld
Publikováno v:
Journal of Investigative Dermatology. 120(3):476-482
Paclitaxel is an alkaloid that inhibits endothelial cell proliferation, motility, and tube formation at nanomolar concentrations. Cationic liposome preparations have been shown to target blood vessels. We wished to explore the possibility that paclit