Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michael T. Rooney"'
Autor:
Robert E. McLaughlin, Elise Gorseth, Michael T. Rooney, Ann E. Eakin, Aryun Kim, Asha S. Nayar, Andy S. Tsai, Kerry E. Murphy-Benenato, Alita A. Miller, Jared L. Crandon, David P. Nicolau, Christina M. Blinn, April Chen, David E. Ehmann, Amy Kutschke, Brian Dangel, Sara A. Patey
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:7743-7752
The objective of this study was to investigate the risk of attenuated efficacy due to adaptive resistance for the siderophore-conjugated monocarbam SMC-3176 in Pseudomonas aeruginosa by using a pharmacokinetic/pharmacodynamic (PK/PD) approach. MICs w
Autor:
Jamal Carlos Saeh, Vibha Oza, Kate Byth, Michael T. Rooney, Lucienne Ronco, Paul Lyne, Danyang Li, Qibin Su, Gurmit Grewal, Victor Kamhi, Edward J. Hennessy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:2041-2045
We have discovered a novel class of heterocyclic sulfonamides that act as antagonists of the S1P1 receptor. While members of this series identified from a high-throughput screen showed promising levels of potency in a cell-based assay measuring the i
Autor:
Amy Kutschke, C. Cederberg, Michael T. Rooney, Boudewijn L. M. de Jonge, Wei Yang, Joseph V. Newman
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:2337-2342
A pyridodiazepine amine inhibitor of Helicobacter pylori glutamate racemase (MurI) was characterized. The compound was selectively active against H. pylori , and growth suppression was shown to be mediated through the inhibition of MurI by several me
Autor:
Terry MacIntyre, Brian Aquila, Edward J. Hennessy, Naomi Laing, Vibha Oza, David Whitston, Victor Kamhi, Jamal Carlos Saeh, Lillian Castriotta, Li Sha, Troy Patterson, Christopher Huntington, Danyang Li, Haiyun Wang, Charles A. Omer, Alexander Hird, Melissa Vasbinder, Donald J. Cook, Michael T. Rooney, Galina Repik, Maureen Hattersley, Ammar Adam
Publikováno v:
Journal of Medicinal Chemistry. 56:9897-9919
A series of dimeric compounds based on the AVPI motif of Smac were designed and prepared as antagonists of the inhibitor of apoptosis proteins (IAPs). Optimization of cellular potency, physical properties, and pharmacokinetic parameters led to the id
Autor:
Li Sha, Kerry E. Murphy-Benenato, Frank Wu, Thomas F. Durand-Reville, Haris Jahic, Hajnalka E. Davis, Ning Gao, Mark Sylvester, Shannon X. Zhao, Olga Quiroga, Erika L. Manyak, Michael T. Rooney, John P. Mueller, Brian Dangel, Andrew D. Ferguson, Mark Zambrowski
A main challenge in the development of new agents for the treatment of Pseudomonas aeruginosa infections is the identification of chemotypes that efficiently penetrate the cell envelope and are not susceptible to established resistance mechanisms. Si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250216b54c9993a14170a724d0151038
https://europepmc.org/articles/PMC4434466/
https://europepmc.org/articles/PMC4434466/
Autor:
David E. Ehmann, Mark Zambrowski, Adam B. Shapiro, Pratik R. Bhagunde, Beesan Tan, Kerry E. Murphy-Benenato, Li Sha, Olga Quiroga, Vincent Galullo, Hajnalka E. Davis, M. R. Manjunatha, Holia Hatoum-Mokdad, Mark Sylvester, Aryun Kim, Haris Jahic, Shannon X. Zhao, Ye Wu, April Chen, Andy S. Tsai, Jennifer J. Harris, Sara A. Patey, Michael T. Rooney, Erika L. Manyak, Thomas F. Durand-Reville, Maria Uria-Nickelsen, John P. Mueller
Publikováno v:
Journal of medicinal chemistry. 58(5)
To identify new agents for the treatment of multi-drug-resistant Pseudomonas aeruginosa, we focused on siderophore-conjugated monocarbams. This class of monocyclic β-lactams are stable to metallo-β-lactamases and have excellent P. aeruginosa activi
Autor:
Brendan Chen, Joseph V. Newman, Robert Albert, Min Lu, Michael T. Rooney, Haiqing Hu, George B. Mullen, Hoan Huynh, Suzanne Stokes, Madhusudhan Reddy Gowravaram, Thomas J. O’Shea, Scott D. Mills
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(1)
Optimization of clearance of adenosine inhibitors of bacterial NAD(+)-dependent DNA ligase is discussed. To reduce Cytochrome P-450-mediated metabolic clearance, many strategies were explored; however, most modifications resulted in compounds with re
Autor:
Terry MacIntyre, Brian Aquila, Edward J. Hennessy, Daniel John Russell, Bin Yang, Dave Witson, Jamal Carlos Saeh, Maureen Hattersley, Paula Lewis, Michael T. Rooney, Charles A. Omer, Galina Repik, Victor Kamhi, Li Sha, Danyang Li, Haiyun Wang, John Lee, Troy Patterson, Naomi Laing, Melissa Vasbinder, Donald J. Cook, Andrew D. Ferguson, Vibha Oza, Alexander Hird
Publikováno v:
Molecular Cancer Therapeutics. 12:B100-B100
Both monomeric and dimeric SMAC (Second Mitochondria-derived Activator of Caspaces) mimetics acting as IAP (Inhibitor of apoptosis proteins) anatgonists have been reported in the clinic as well as extensively in the literature (1). The first four ami
Autor:
Xiaolan Zheng, Michael T. Rooney, Michael Howard Block, James E. Dowling, Michelle Lamb, Les A. Dakin, Jon Read, Erika Krasnickas Keeton, Tao Zhang, Paul Lyne, Tina Howard, Allan Wu, Isabelle Green, Erin Code, Xiaomei Feng, Dennis Huszar, Alexander Hird, Andrew D. Ferguson, Hannah Pollard, Huawei Chen
Publikováno v:
Cancer Research. 73:2353-2353
The PIM serine/threonine kinase family, composed of three highly homologous members, PIM-1, PIM-2 and PIM-3, are upregulated in leukemias and lymphomas, including AML, NHL and CLL, highlighting the potential of these kinases as therapeutic targets in
Publikováno v:
International Journal of Antimicrobial Agents. 29:S200