Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Michael T. Lin"'
Autor:
Claudia G. Almeida, Davide Tampellini, Reisuke H. Takahashi, Paul Greengard, Michael T. Lin, Eric M. Snyder, Gunnar K. Gouras
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 187-198 (2005)
Synaptic dysfunction is increasingly viewed as an early manifestation of Alzheimer's disease (AD), but the cellular mechanism by which β-amyloid (Aβ) may affect synapses remains unclear. Since cultured neurons derived from APP mutant transgenic mic
Externí odkaz:
https://doaj.org/article/fe6d6879e48d4dce974c0d4687b5270c
Autor:
Reisuke H Takahashi, Estibaliz Capetillo-Zarate, Michael T Lin, Teresa A Milner, Gunnar K Gouras
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e51965 (2013)
Pathologic aggregation of β-amyloid (Aβ) peptide and the axonal microtubule-associated protein tau protein are hallmarks of Alzheimer's disease (AD). Evidence supports that Aβ peptide accumulation precedes microtubule-related pathology, although t
Externí odkaz:
https://doaj.org/article/f2d0a2b809744636960a60dd305d20fc
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15546 (2010)
Rod-like structures composed of actin and the actin-binding protein cofilin are found in Alzheimer's disease (AD) patients. However, the mechanisms underlying formation of these structures and their pathological consequences are still largely unknown
Externí odkaz:
https://doaj.org/article/31a0e9274eda4838bb228557c7a3fc9d
Autor:
Tao Ma, Charles A Hoeffer, Estibaliz Capetillo-Zarate, Fangmin Yu, Helen Wong, Michael T Lin, Davide Tampellini, Eric Klann, Robert D Blitzer, Gunnar K Gouras
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
The mammalian target of rapamycin (mTOR) is an evolutionarily conserved Ser/Thr protein kinase that plays a pivotal role in multiple fundamental biological processes, including synaptic plasticity. We explored the relationship between the mTOR pathwa
Externí odkaz:
https://doaj.org/article/7bb58ed8478441b6814903076fbbea7a
Autor:
Michael T. Lin, Alan Roy Jacobs, Rahman Mahmudur, Alon Seifan, Krista Ryon, Christine A. Ganzer, Henriquez Adolfo, Cindy Shih, Richard S. Isaacson, Molly Greenwald
Publikováno v:
Current Aging Science
Background: Prodromal Neurodegenerative Disease (ND) due to tauopathies such as Alzheimer’s Disease (AD) and Synucleinopathies (SN) such as Parkinson's Disease (PD) and Dementia with Lewy Bodies (DLB) present subtly. Although ND are considered cogn
Autor:
Michael T. Lin, Katherine Hackett, Christine A. Ganzer, Mahreen Ahmed, Robert Krikorian, Chiashin Shih, Richard S. Isaacson, Peter Tamboer, Alon Seifan, Max J. Pensack, Matthew W. Schelke, Sheila Steinhof, Adolfo M. Henriquez, Hemali Patel
Publikováno v:
Research in developmental disabilities. 77
Background Neurodevelopmental learning and attentional disorders (NLAD) such as dyslexia, dyscalculia and attention deficit hyperactivity disorder (ADHD) affect at least 6% of the adult population or more. They are associated with atypical cognitive
Autor:
Jaya M. Satagopan, Richards Elizabeth C, Raymond E. Baser, Kenneth Cheung, Denise D. Correa, Sasan Karimi, Michael T. Lin, Lisa M. DeAngelis, John K. Lyo, Irene Orlow
Publikováno v:
Neurology. 83:320-327
Objective: The goal of this study was to assess whether the APOE e4 allele and other APOE single nucleotide polymorphisms (SNPs) influence neuropsychological and neuroimaging outcomes in patients with brain tumors. Methods: Two hundred eleven patient
Publikováno v:
American Journal of Physiology-Cell Physiology. 303:C318-C327
Small- and intermediate-conductance Ca2+-activated K+ channels (SK3/Kcnn3 and IK1/Kcnn4) are expressed in vascular endothelium. Their activities play important roles in regulating vascular tone through their modulation of intracellular concentration
Autor:
David Simon, Rebecca A. Betensky, Thomas Arzberger, Ippolita Cantuti-Castelvetri, Yong B. Tan, Michael T. Lin, Kangni Zheng, Andrew J. Lees, M. Flint Beal, Katie E. Jackson
Publikováno v:
Annals of Neurology. 71:850-854
Somatic mutations in mitochondrial DNA (mtDNA) are hypothesized to play a role in Parkinson disease (PD), but large increases in mtDNA mutations have not previously been found in PD, potentially because neurons with high mutation levels degenerate an
Publikováno v:
The Journal of Experimental Medicine
To be added
There is extensive evidence that cholesterol and membrane lipids play a key role in Alzheimer disease (AD) pathogenesis. Cyclodextrins (CD) are cyclic oligosaccharide compounds widely used to bind cholesterol. Because CD exerts signi
There is extensive evidence that cholesterol and membrane lipids play a key role in Alzheimer disease (AD) pathogenesis. Cyclodextrins (CD) are cyclic oligosaccharide compounds widely used to bind cholesterol. Because CD exerts signi