Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Michael T. Kirber"'
Autor:
Qingde Zhou, Allen Yen, Grzegorz Rymarczyk, Hirohide Asai, Chelsea Trengrove, Nadine Aziz, Michael T. Kirber, Gustavo Mostoslavsky, Tsuneya Ikezu, Benjamin Wolozin, Victoria M. Bolotina
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
PLA2g6 regulates store-operated Ca2+ entry and is linked to Parkinson’s disease. Here, Zhou et al find faulty PLA2g6-dependent Ca2+signaling in idiopathic PD patients, and show that its impairment triggers autophagic dysfunction and loss of dopamin
Externí odkaz:
https://doaj.org/article/33e1f0f92a0c4245b5c7415b37aee723
Autor:
Jeffrey R. Simard, Tova Meshulam, Biju K. Pillai, Michael T. Kirber, Kellen Brunaldi, Su Xu, Paul F. Pilch, James A. Hamilton
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 5, Pp 914-922 (2010)
Ectopic expression of caveolin-1 in HEK293 cells enhances FA sequestration in membranes as measured by a pH-sensitive fluorescent dye (1). We hypothesized that sequestration of FA is due to the enrichment of caveolin in the cytosolic leaflet and its
Externí odkaz:
https://doaj.org/article/1262d82de30b417b94bd7dccecea83a0
Autor:
Ivan Luptak, Robert J. Morgan, Daniel Moverman, Michael T. Kirber, Hannah Sarnak, Markus Bachschmid, Tomas Baka, Wilson S. Colucci, David R. Pimentel, Dominique Croteau
Publikováno v:
Int J Biochem Cell Biol
Calcium (Ca(2+)), an important second messenger, regulates many cellular activities and varies spatiotemporally within the cell. Conventional methods to monitor Ca(2+) changes, such as synthetic Ca(2+) indicators, are not targetable, while geneticall
Autor:
Wilson S. Colucci, Ivan Luptak, Dominique Croteau, Michael T. Kirber, Deborah A. Siwik, Jena B Goodman, David R. Pimentel
Publikováno v:
Free Radical Biology and Medicine. 128:S27
Background Although sarco-endoplasmic reticulum ATPase-2 (SERCA) is located in close proximity to mitochondria, its role in the regulation of mitochondrial calcium ([Ca2+]m) is not clear. Reactive oxygen species (ROS) such as H2O2 can oxidize SERCA a
Publikováno v:
Journal of Biological Chemistry. 287:40745-40757
Store-operated Ca(2+) entry is important for cell migration.This study presents characterization of localization and roles of Orai1, STIM1, and PLA2g6 in adhesion dynamics during cell migration.Orai1 and PLA2g6 are involved in adhesion formation at t
Autor:
Benjamin Wolozin, Grzegorz Rymarczyk, Michael T. Kirber, Qingde Zhou, Allen Yen, Victoria M. Bolotina, Hirohide Asai, Chelsea Trengrove, Nadine M. Aziz, Tsuneya Ikezu, Gustavo Mostoslavsky
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature Communications
Nature Communications
The etiology of idiopathic Parkinson's disease (idPD) remains enigmatic despite recent successes in identification of genes (PARKs) that underlie familial PD. To find new keys to this incurable neurodegenerative disorder we focused on the poorly unde
Autor:
Jessica E. Teague, David H. Sherr, Jennifer J. Schlezinger, Michael T. Kirber, Heui-Young Ryu
Publikováno v:
The Journal of Immunology. 185:3369-3378
Intercellular communication is an essential process in stimulating lymphocyte development and in activating and shaping an immune response. B cell development requires cell-to-cell contact with and cytokine production by bone marrow stromal cells. Ho
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 460:791-802
The role of protein kinase C (PKC) in Ca(2+) release through ryanodine receptors (RyRs) in the sarcoplasmic reticulum (SR) of vascular smooth muscle cells (SMCs) is not well understood. Caffeine was used to activate RyRs and the intracellular Ca(2+)
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 286:G833-G843
Ulcerative colitis (UC) affects colonic motor function, but the mechanism responsible for this motor dysfunction is not well understood. We have shown that neurokinin A (NKA) may be an endogenous neurotransmitter mediating contraction of human sigmoi
Autor:
Jose Behar, Weibiao Cao, Uy Dong Sohn, Piero Biancani, Qian Chen, Michael T. Kirber, Karen M. Harnett, Nayoung Kim
Publikováno v:
American Journal of Physiology-Cell Physiology. 280:C980-C992
ACh-induced contraction of esophageal circular muscle (ESO) depends on Ca2+influx and activation of protein kinase Cε (PKCε). PKCε, however, is known to be Ca2+independent. To determine where Ca2+is needed in this PKCε-mediated contractile pathwa