Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michael T. Cullen"'
Publikováno v:
Nature Reviews Cancer. 22:467-480
Publikováno v:
Nature reviews. Cancer. 22(8)
The natural mammalian polyamines putrescine, spermidine and spermine are essential for both normal and neoplastic cell function and replication. Dysregulation of metabolism of polyamines and their requirements is common in many cancers. Both clinical
Autor:
Nimit Singhal, Darren Sigal, Niall C. Tebbutt, Aram F Hezel, Adnan Nagrial, Sumit Lumba, Thomas J. George, Sheri Lynn Smith, Suzanne Gagnon, Michael T. Cullen, Michael Walker
Publikováno v:
Journal of Clinical Oncology. 40:575-575
575 Background: SBP-101, a polyamine metabolic inhibitor, inhibited growth in 6 human pancreatic ductal adenocarcinoma (PDA) cell lines and 3 murine xenograft tumor models of human PDA. SBP-101 monotherapy in heavily pre-treated PDA patients (> 2 pri
Autor:
Sumit Lumba, Suzanne Gagnon, Michael T. Cullen, Aram F. Hezel, Thomas J. George, Darren Sigal, Nimit Singhal, Adnan Nagrial, Niall C. Tebbutt, S. Smith, Michael Walker
Publikováno v:
Journal of Clinical Oncology. 39:4127-4127
4127 Background: SBP-101, a polyamine metabolic inhibitor, inhibited growth in 6 human pancreatic ductal adenocarcinoma (PDA) cell lines and 3 murine xenograft tumor models of human PDA. SBP-101 monotherapy in heavily pre-treated PDA patients (> 2 pr
Autor:
Thomas J. George, Michael T. Cullen, Dusan Kotasek, Michael Walker, Niall C. Tebbutt, Sumit Lumba, Suzanne Gagnon, Adnan Nagrial, S. Smith
Publikováno v:
Journal of Clinical Oncology. 38:710-710
710 Background: SBP-101, a polyamine metabolic inhibitor, inhibited growth in 6 human pancreatic ductal adenocarcinoma (PDA) cell lines and 3 murine xenograft tumor models of human PDA. SBP-101 monotherapy in heavily pre-treated PDA patients (> 2 pri
Autor:
Mitesh J. Borad, Michael Walker, Michael T. Cullen, Ajit K. Shah, Dusan Kotasek, Niall C. Tebbutt, Suzanne Gagnon, Erkut Borazanci, S. Smith
Publikováno v:
Journal of Clinical Oncology. 36:e16231-e16231
e16231Background: SBP-101 (diethyl dihydroxyhomospermine), a polyamine (PA) analogue of spermine, inhibited growth in 6 human PDA cell lines and 3 murine xenograft tumor models. A Phase 1 dose esca...
Publikováno v:
The Journal of Clinical Pharmacology. 45:589-596
This study evaluated the safety and pharmacokinetics of consecutive multiple-day dosing of palonosetron. Sixteen healthy subjects received an intravenous bolus dose of palonosetron 0.25 mg (n = 12) or placebo (n = 4) daily for 3 consecutive days. Saf
Autor:
Anil K. Bhandari, Ronald W. Hawkinson, Barry L. Alpert, Edward L.C. Pritchett, Michael T. Cullen, Albert L. Waldo, Jefferey L. Anderson, Richard W. Henthorn, E.Michael Gilbert
Publikováno v:
American Heart Journal. 124:381-386
The purpose of this study was to determine whether symptoms recorded at the time of transtelephonic ECG monitoring (TTEM) correlate with attacks of paroxysmal supraventricular tachycardia (PSVT) or paroxysmal atrial fibrillation (PAF). We studied 113
Autor:
Rena Buckstein, Maria R. Baer, Hagop M. Kantarjian, Lucy A. Godley, Julie S. Larsen, Maher Albitar, David P. Steensma, Sujata Arora, James L. Slack, Guillermo Garcia-Manero, Michael T. Cullen
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 27(23)
Purpose Decitabine, a DNA-targeted hypomethylating agent, is approved by the United States Food and Drug Administration for treatment of patients with myelodysplastic syndromes (MDS) on a schedule of 15 mg/m2 administered via intravenous (IV) infusio
Autor:
Robert Dreicer, Michael T. Cullen, Joseph S. Bubalo, Craig R. Nichols, Lawrence H. Einhorn, Mary J. Brames
Publikováno v:
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 15(11)
The aims of this study were to assess the safety and antiemetic efficacy of multiple-day dosing of palonosetron plus dexamethasone in patients receiving highly emetogenic multiple-day cisplatin-based chemotherapy for germ cell tumors.Forty-one men un