Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Michael T. Boyne"'
Autor:
William J. Kelley, Kathleen M. Wragg, Judy Chen, Tushar Murthy, Qichen Xu, Michael T. Boyne, Joseph R. Podojil, Adam Elhofy, Daniel R. Goldstein
Publikováno v:
JCI Insight, Vol 7, Iss 15 (2022)
Older people exhibit dysregulated innate immunity to respiratory viral infections, including influenza and SARS-CoV-2, and show an increase in morbidity and mortality. Nanoparticles are a potential practical therapeutic that could reduce exaggerated
Externí odkaz:
https://doaj.org/article/4576ad08e65547c38dee32f1176ea356
Autor:
Joseph R. Podojil, Andrew C. Cogswell, Ming-Yi Chiang, Valerie Eaton, Igal Ifergan, Tobias Neef, Dan Xu, Khyati A. Meghani, Yanni Yu, Sophia M. Orbach, Tushar Murthy, Michael T. Boyne, Adam Elhofy, Lonnie D. Shea, Joshua J. Meeks, Stephen D. Miller
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cancer treatment utilizing infusion therapies to enhance the patient’s own immune response against the tumor have shown significant functionality in a small subpopulation of patients. Additionally, advances have been made in the utilization of nano
Externí odkaz:
https://doaj.org/article/ab783c6c26c045b0aab255a9140c3f66
Autor:
Joseph R. Podojil, Samantha Genardi, Ming-Yi Chiang, Sandeep Kakade, Tobias Neef, Tushar Murthy, Michael T. Boyne, Adam Elhofy, Stephen D. Miller
Publikováno v:
The Journal of Immunology. 209:465-475
Type 1 diabetes (T1D) is an autoimmune disease characterized by T and B cell responses to proteins expressed by insulin-producing pancreatic β cells, inflammatory lesions within islets (insulitis), and β cell loss. We previously showed that Ag-spec
Autor:
Laxminarasimha, Donthireddy, Prashanthi, Vonteddu, Tushar, Murthy, Taekyoung, Kwak, Rukiye-Nazan, Eraslan, Joseph R, Podojil, Adam, Elhofy, Michael T, Boyne, John J, Puisis, Filippo, Veglia, Surya S, Singh, Farokh, Dotiwala, Luis J, Montaner, Dmitry I, Gabrilovich
Publikováno v:
Journal of Cancer. 13:1933-1944
In this study, we evaluated the ability of negatively charged bio-degradable nanoparticles, ONP- 302, to inhibit tumor growth. Therapeutic treatment with ONP-302 in vivo resulted in a marked delay in tumor growth in three different syngeneic tumor mo
Publikováno v:
In Journal of Pharmaceutical and Biomedical Analysis August-September 2012 67-68:42-50
Autor:
William J. Kelley, Kathleen M. Wragg, Judy Chen, Tushar Murthy, Qichen Xu, Michael T. Boyne, Joseph R. Podojil, Adam Elhofy, Daniel R. Goldstein
Publikováno v:
JCI insight. 7(15)
Older people exhibit dysregulated innate immunity to respiratory viral infections, including influenza and SARS-CoV-2, and show an increase in morbidity and mortality. Nanoparticles are a potential practical therapeutic that could reduce exaggerated
Autor:
Michael T. Boyne, Anneliese Faustino, John E. Schiel, Eric Pang, Deepali Rathore, Sarah Rogstad
Publikováno v:
Expert Review of Proteomics. 15:431-449
Mass spectrometry (MS) is widely used in the characterization of biomolecules including peptide and protein therapeutics. These biotechnology products have seen rapid growth over the past few decades and continue to dominate the global pharmaceutical
Autor:
Tobias L. Freitag, Joseph A. Murray, Michael T. Boyne, Michael Koren, Stephen D. Miller, Daniel A. Leffler, Daniel R. Getts, Mark Matson, Thomas H. Oliphant, Amy Morris, Adam C. Bledsoe, Jocelyn A. Silvester, Seppo Meri, Glennda Smithson, Michele Gerber, Robert Fogel, Ciaran P. Kelly, Paul K. Haynes, Adam Elhofy, M. Roy First, Mark Turner, Tsung Teh Wu, Barbara E. Rizzardi, Joseph R. Podojil
Publikováno v:
Gastroenterology
BACKGROUND & AIMS: In celiac disease (CeD), gluten induces immune activation, leading to enteropathy. TAK-101, gluten protein (gliadin) encapsulated in negatively charged poly(dl-lactide-co-glycolic acid) nanoparticles, is designed to induce gluten-s
Publikováno v:
Journal of the American Society for Mass Spectrometry. 28:786-794
The characterization sections of biologics license applications (BLAs) approved by the United States Food and Drug Administration (FDA) between 2000 and 2015 were investigated to examine the extent of the use of mass spectrometry. Mass spectrometry w
Autor:
Matthew R. Brown, Cyrus Agarabi, Sarah Rogstad, Brittany K. Chavez, Scott Lute, Michael T. Boyne, Kurt Brorson, David Awotwe-Otoo, Erik K. Read
Publikováno v:
Biotechnology Progress. 33:163-170
Linkage of upstream cell culture with downstream processing and purification is an aspect of Quality by Design crucial for efficient and consistent production of high quality biopharmaceutical proteins. In a previous Plackett-Burman screening study o