Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Michael T. Bethune"'
Publikováno v:
BioTechniques, Vol 62, Iss 3, Pp 123-130 (2017)
Peptide–major histocompatibility complex (pMHC) multimers enable the detection, characterization, and isolation of antigen-specific T-cell subsets at the single-cell level via flow cytometry and fluorescence microscopy. These labeling reagents expl
Externí odkaz:
https://doaj.org/article/1a26b447ac5340b8b5b5db3e954125e6
Autor:
Songming Peng, Jesse M. Zaretsky, Alphonsus H.C. Ng, William Chour, Michael T. Bethune, Jongchan Choi, Alice Hsu, Elizabeth Holman, Xiaozhe Ding, Katherine Guo, Jungwoo Kim, Alexander M. Xu, John E. Heath, Won Jun Noh, Jing Zhou, Yapeng Su, Yue Lu, Jami McLaughlin, Donghui Cheng, Owen N. Witte, David Baltimore, Antoni Ribas, James R. Heath
Publikováno v:
Cell Reports, Vol 28, Iss 10, Pp 2728-2738.e7 (2019)
Summary: Neoantigen-specific T cells are increasingly viewed as important immunotherapy effectors, but physically isolating these rare cell populations is challenging. Here, we describe a sensitive method for the enumeration and isolation of neoantig
Externí odkaz:
https://doaj.org/article/43a6df712a824f30a578af81377be174
Autor:
Susan P. Foy, Kyle Jacoby, Daniela A. Bota, Theresa Hunter, Zheng Pan, Eric Stawiski, Yan Ma, William Lu, Songming Peng, Clifford L. Wang, Benjamin Yuen, Olivier Dalmas, Katharine Heeringa, Barbara Sennino, Andy Conroy, Michael T. Bethune, Ines Mende, William White, Monica Kukreja, Swetha Gunturu, Emily Humphrey, Adeel Hussaini, Duo An, Adam J. Litterman, Boi Bryant Quach, Alphonsus H. C. Ng, Yue Lu, Chad Smith, Katie M. Campbell, Daniel Anaya, Lindsey Skrdlant, Eva Yi-Hsuan Huang, Ventura Mendoza, Jyoti Mathur, Luke Dengler, Bhamini Purandare, Robert Moot, Michael C. Yi, Roel Funke, Alison Sibley, Todd Stallings-Schmitt, David Y. Oh, Bartosz Chmielowski, Mehrdad Abedi, Yuan Yuan, Jeffrey A. Sosman, Sylvia M. Lee, Adam J. Schoenfeld, David Baltimore, James R. Heath, Alex Franzusoff, Antoni Ribas, Arati V. Rao, Stefanie J. Mandl
Publikováno v:
Nature, vol 615, iss 7953
T cell receptors (TCRs) enable T cells to specifically recognize mutations in cancer cells1–3. Here we developed a clinical-grade approach based on CRISPR–Cas9 non-viral precision genome-editing to simultaneously knockout the two endogenous TCR g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd691b6fa2cf73c26cc536f7201c6b0c
https://escholarship.org/uc/item/2g96s8v7
https://escholarship.org/uc/item/2g96s8v7
Autor:
Michael T Bethune, Marvin H Gee, Mario Bunse, Mark S Lee, Eric H Gschweng, Meghana S Pagadala, Jing Zhou, Donghui Cheng, James R Heath, Donald B Kohn, Michael S Kuhns, Wolfgang Uckert, David Baltimore
Publikováno v:
eLife, Vol 5 (2016)
T cells engineered to express a tumor-specific αβ T cell receptor (TCR) mediate anti-tumor immunity. However, mispairing of the therapeutic αβ chains with endogenous αβ chains reduces therapeutic TCR surface expression and generates self-reacti
Externí odkaz:
https://doaj.org/article/6a88487d0cf04964bf9e93ce1693a670
Autor:
B. Hutchinson, J Harraway, E Kluckow, Mark D. Pertile, Ricardo Palma-Dias, A Poulton, Debbie Nisbet, Anthea Lindquist, Melody Menezes, R. McCoy, Jane Halliday, Zeffie Poulakis, L. Bonacquisto, A Howden, Nicole Martin, L. Gugasyan, A Kulkarni, Lisa Hui, F. da Silva Costa, Michael T. Bethune
Publikováno v:
Ultrasound in Obstetrics & Gynecology. 56:215-224
OBJECTIVES: To perform individual record linkage of women undergoing screening with cell-free DNA (cfDNA), combined first-trimester screening (CFTS), second-trimester serum screening (STSS), and/or prenatal and postnatal cytogenetic testing with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aef597ca4ec2953c5207f15f5a7aebe
https://doi.org/10.1002/uog.21899
https://doi.org/10.1002/uog.21899
Publikováno v:
Sonography. 6:103-109
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d462028eb57831280f384defe841ab97
https://doi.org/10.1002/sono.12191
https://doi.org/10.1002/sono.12191
Autor:
Margaret B. Swift, Jesse M. Zaretsky, Alok V. Joglekar, Michael T. Bethune, David Baltimore, Stephanie Wong, John D. Jeppson, Songming Peng, James R. Heath, Michael T. Leonard, Antoni Ribas, Guideng Li
Publikováno v:
Nature methods, vol 16, iss 2
Nature methods
Nature methods
CD8+ T cells recognize and eliminate tumors in an antigen-specific manner. Despite progress in characterizing the antitumor T cell repertoire and function, identifying their target antigens remains a challenge. Here, we describe the use of chimeric r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddde0c193708314b7132a967ac83d6a4
https://doi.org/10.1038/s41592-018-0304-8
https://doi.org/10.1038/s41592-018-0304-8
Autor:
Ricardo Palma-Dias, J Harraway, Debbie Nisbet, Michael T. Bethune, E Kluckow, Mark D. Pertile, Fiona Norris, L Bonacquisto, Anthea Lindquist, B. Hutchinson, R. McCoy, Cecilia Pynaker, Melody Menezes, Fabricio da Silva Costa, A Poulton, Lisa Hui, L. Gugasyan, A Kulkarni, Jane Halliday, A Howden, Zeffie Poulakis, Nicole Martin
Publikováno v:
American Journal of Obstetrics and Gynecology. 225:527.e1-527.e12
The American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine recently recommended offering genetic counseling and diagnostic testing for enlarged nuchal translucency at ≥3.0 mm, regardless of previous negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7336a2c4ee538ef57d48fd662b083066
https://doi.org/10.1016/j.ajog.2021.03.050
https://doi.org/10.1016/j.ajog.2021.03.050
Publikováno v:
BioTechniques. 62:123-130
Peptide–major histocompatibility complex (pMHC) multimers enable the detection, characterization, and isolation of antigen-specific T-cell subsets at the single-cell level via flow cytometry and fluorescence microscopy. These labeling reagents expl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::befd7728715d4d3ab79a31309554a468
https://doi.org/10.2144/000114525
https://doi.org/10.2144/000114525
Autor:
John E. Heath, Alphonsus H. C. Ng, Songming Peng, Won Jun Noh, Jami McLaughlin, William Chour, Xiaozhe Ding, Michael T. Bethune, Antoni Ribas, Katherine Guo, Jongchan Choi, Yapeng Su, Alice Hsu, Jungwoo Kim, David Baltimore, Donghui Cheng, Elizabeth Holman, Jesse M. Zaretsky, Jing Zhou, James R. Heath, Yue Lu, Alexander M. Xu, Owen N. Witte
Publikováno v:
Cell reports
Cell reports, vol 28, iss 10
Cell Reports, Vol 28, Iss 10, Pp 2728-2738.e7 (2019)
Cell reports, vol 28, iss 10
Cell Reports, Vol 28, Iss 10, Pp 2728-2738.e7 (2019)
SUMMARY Neoantigen-specific T cells are increasingly viewed as important immunotherapy effectors, but physically isolating these rare cell populations is challenging. Here, we describe a sensitive method for the enumeration and isolation of neoantige
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c69d974ca195fd2061e9b5140e04cab
https://resolver.caltech.edu/CaltechAUTHORS:20190903-130240129
https://resolver.caltech.edu/CaltechAUTHORS:20190903-130240129