Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Michael T Reinartz"'
Autor:
Irena Brunskole Hummel, Michael T Reinartz, Solveig Kälble, Heike Burhenne, Frank Schwede, Armin Buschauer, Roland Seifert
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64556 (2013)
In neutrophils, activation of the β2-adrenergic receptor (β2AR), a Gs-coupled receptor, inhibits inflammatory responses, which could be therapeutically exploited. The aim of this study was to evaluate the effects of various β2AR ligands on adenosi
Externí odkaz:
https://doaj.org/article/bea713f0dd944c708b2197156e85c245
Autor:
Roland Seifert, Michael T. Reinartz, Irving W. Wainer, Solveig Kälble, Timo Littmann, Martin Göttle, Takeaki Ozawa
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 355:183-190
Beyond canonical signaling via Gαs and cAMP, the concept of functional selectivity at β2-adrenoceptors (β2ARs) describes the ability of adrenergic drugs to stabilize ligand-specific receptor conformations to initiate further signaling cascades com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116a11f0000f7b65521f9069064a0065
https://doi.org/10.1124/jpet.115.227959
https://doi.org/10.1124/jpet.115.227959
Autor:
Roland Seifert, Christine Happle, Ralph Scherer, Michael T. Reinartz, Solveig Kälble, Michael Kabesch, Martin Wetzke
Publikováno v:
Allergy. 71(8)
Asthma can be controlled well in most patients by inhaled β-adrenoreceptor (β2 AR) agonists and steroids. Poor response to β2 AR agonists is difficult to predict, especially in young children and by lung function testing, which may be affected by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cac7ed6f91c8f85723c49c2c372db0
https://pubmed.ncbi.nlm.nih.gov/27091647
https://pubmed.ncbi.nlm.nih.gov/27091647
Autor:
Timo Littmann, Stefan Dove, Irving W. Wainer, Roland Seifert, Takeaki Ozawa, Michael T. Reinartz, Volkhard Kaever, Solveig Kälble
Functional selectivity is well established as an underlying concept of ligand-specific signaling via G protein-coupled receptors (GPCRs). Functionally, selective drugs could show greater therapeutic efficacy and fewer adverse effects. Dual coupling o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f11749273e3f8ed80565fed459a3dc
Autor:
Alexander Wirth, Masha Y. Niv, Noga Kowalsman, Ute Renner, Andre Zeug, Nataliya Gorinski, Michael T. Reinartz, Roland Seifert, Evgeni Ponimaskin
Publikováno v:
Molecular pharmacology. 82(3)
Experimental evidence suggests that most members of class A G-protein coupled receptors (GPCRs) can form homomers and heteromers in addition to functioning as single monomers. In particular, serotonin (5-HT) receptors were shown to homodimerize and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e507388de0fb4ded8ace516cd95efe24
https://pubmed.ncbi.nlm.nih.gov/22669805
https://pubmed.ncbi.nlm.nih.gov/22669805