Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Michael T Meister"'
1
Akademický článek
Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes
Autor: Michael T Meister, Marian J A Groot Koerkamp, Terezinha de Souza, Willemijn B Breunis, Ewa Frazer‐Mendelewska, Mariël Brok, Jeff DeMartino, Freek Manders, Camilla Calandrini, Hinri H D Kerstens, Alex Janse, M Emmy M Dolman, Selma Eising, Karin P S Langenberg, Marc van Tuil, Rutger R G Knops, Sheila Terwisscha van Scheltinga, Laura S Hiemcke‐Jiwa, Uta Flucke, Johannes H M Merks, Max M van Noesel, Bastiaan B J Tops, Jayne Y Hehir‐Kwa, Patrick Kemmeren, Jan J Molenaar, Marc van de Wetering, Ruben van Boxtel, Jarno Drost, Frank C P Holstege
Publikováno v: EMBO Molecular Medicine, Vol 14, Iss 10, Pp 1-23 (2022)
Abstract Rhabdomyosarcomas (RMS) are mesenchyme‐derived tumors and the most common childhood soft tissue sarcomas. Treatment is intense, with a nevertheless poor prognosis for high‐risk patients. Discovery of new therapies would benefit from addi
Externí odkaz: https://doaj.org/article/bfe59c6efb18489cb65ad4d76f02464c
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2
Akademický článek
Selective BH3 mimetics synergize with BET inhibition to induce mitochondrial apoptosis in rhabdomyosarcoma cells
Autor: Ufuk Erdogdu, Nadezda Dolgikh, Stephanie Laszig, Vinzenz Särchen, Michael T. Meister, Marek Wanior, Stefan Knapp, Cathinka Boedicker
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 24, Iss 2, Pp 109-119 (2022)
BH3 mimetics are promising novel anticancer therapeutics. By selectively inhibiting BCL-2, BCL-xL, or MCL-1 (i.e. ABT-199, A-1331852, S63845) they shift the balance of pro- and anti-apoptotic proteins in favor of apoptosis. As Bromodomain and Extra T
Externí odkaz: https://doaj.org/article/0403c2302550453288f621f27f8c9d7f
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3
Imaging in rhabdomyosarcoma: a patient journey
Autor: Isabelle S. A. de Vries, Roelof van Ewijk, Laura M. E. Adriaansen, Anneloes E. Bohte, Arthur J. A. T. Braat, Raquel Dávila Fajardo, Laura S. Hiemcke-Jiwa, Marinka L. F. Hol, Simone A. J. ter Horst, Bart de Keizer, Rutger R. G. Knops, Michael T. Meister, Reineke A. Schoot, Ludi E. Smeele, Sheila Terwisscha van Scheltinga, Bas Vaarwerk, Johannes H. M. Merks, Rick R. van Rijn
Publikováno v: Pediatric Radiology. 53:788-812
Rhabdomyosarcoma, although rare, is the most frequent soft tissue sarcoma in children and adolescents. It can present as a mass at nearly any site in the body, with most common presentations in the head and neck, genitourinary tract and extremities.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::396b232bdbbd56b5a571da9336dc7545
https://doi.org/10.1007/s00247-023-05596-8
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4
Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma
Autor: Jeff DeMartino, Michael T. Meister, Lindy L. Visser, Mariël Brok, Marian J. A. Groot Koerkamp, Amber K. L. Wezenaar, Laura S. Hiemcke-Jiwa, Terezinha de Souza, Johannes H. M. Merks, Anne C. Rios, Frank C. P. Holstege, Thanasis Margaritis, Jarno Drost
Publikováno v: Nature Communications. 14
Paediatric rhabdomyosarcoma (RMS) is a soft tissue malignancy of mesenchymal origin that is thought to arise as a consequence of derailed myogenic differentiation. Despite intensive treatment regimens, the prognosis for high-risk patients remains dis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a864354a0caaf90decfe0c946bf88d9
https://doi.org/10.1038/s41467-023-38886-8
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5
Data from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets
Autor: Olaf Witt, Stefan M. Pfister, David Capper, Jan J. Molenaar, David T.W. Jones, Annette Kopp-Schneider, Peter Lichter, Ruth Witt, Angelika Freitag, Uta Dirksen, Andreas von Deimling, Felix Sahm, David Reuss, Stephan Wolf, Natalie Jäger, Till Milde, C. Michel Zwaan, Bianca Goemans, Maria Filippidou, Antonis Kattamis, Bernarda Kazanowska, Olli Lohi, Nicolas U. Gerber, Caroline Hutter, Ingrid Øra, Roman Tremmel, Matthias Schwab, Simone Hettmer, Monika Scheer, Michael T. Meister, Ewa Koscielniak, Simone Fulda, Petra Ketteler, Ines B. Brecht, Dominik T. Schneider, Michael C. Frühwald, Stefanie Hecker-Nolting, Michaela Nathrath, Wilhelm Wößmann, Birgit Burkhardt, Angelika Eggert, Matthias Fischer, Frank Westermann, Norbert Graf, Peter Vorwerk, Gabriele Calaminus, André O. von Bueren, Christof M. Kramm, Irene Schmid, Dietrich von Schweinitz, Stephan Tippelt, Gudrun Fleischhack, Jan-Henning Klusmann, Dirk Reinhardt, Roland Meisel, Arndt Borkhardt, Andrej Lissat, Andreas E. Kulozik, Arend von Stackelberg, Kerstin Grund, Christian Sutter, Steffen Hirsch, Nicola Dikow, Kathrin Schramm, Mirjam Blattner-Johnson, Pascal D. Johann, Sebastian Stark, Gnana Prakash Balasubramanian, Barbara C. Jones, Petra Fiesel, Karin P.S. Langenberg, Kristian W. Pajtler, Elke Pfaff, Cornelis M. van Tilburg
INFORM is a prospective, multinational registry gathering clinical and molecular data of relapsed, progressive, or high-risk pediatric patients with cancer. This report describes long-term follow-up of 519 patients in whom molecular alterations were
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff21fae7f2dbec73c8ce658d2e5de67
https://doi.org/10.1158/2159-8290.c.6549356.v1
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6
Supplementary Table from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets
Autor: Olaf Witt, Stefan M. Pfister, David Capper, Jan J. Molenaar, David T.W. Jones, Annette Kopp-Schneider, Peter Lichter, Ruth Witt, Angelika Freitag, Uta Dirksen, Andreas von Deimling, Felix Sahm, David Reuss, Stephan Wolf, Natalie Jäger, Till Milde, C. Michel Zwaan, Bianca Goemans, Maria Filippidou, Antonis Kattamis, Bernarda Kazanowska, Olli Lohi, Nicolas U. Gerber, Caroline Hutter, Ingrid Øra, Roman Tremmel, Matthias Schwab, Simone Hettmer, Monika Scheer, Michael T. Meister, Ewa Koscielniak, Simone Fulda, Petra Ketteler, Ines B. Brecht, Dominik T. Schneider, Michael C. Frühwald, Stefanie Hecker-Nolting, Michaela Nathrath, Wilhelm Wößmann, Birgit Burkhardt, Angelika Eggert, Matthias Fischer, Frank Westermann, Norbert Graf, Peter Vorwerk, Gabriele Calaminus, André O. von Bueren, Christof M. Kramm, Irene Schmid, Dietrich von Schweinitz, Stephan Tippelt, Gudrun Fleischhack, Jan-Henning Klusmann, Dirk Reinhardt, Roland Meisel, Arndt Borkhardt, Andrej Lissat, Andreas E. Kulozik, Arend von Stackelberg, Kerstin Grund, Christian Sutter, Steffen Hirsch, Nicola Dikow, Kathrin Schramm, Mirjam Blattner-Johnson, Pascal D. Johann, Sebastian Stark, Gnana Prakash Balasubramanian, Barbara C. Jones, Petra Fiesel, Karin P.S. Langenberg, Kristian W. Pajtler, Elke Pfaff, Cornelis M. van Tilburg
Supplementary Table from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1608d894805fd1b25b55cb28e9714e9f
https://doi.org/10.1158/2159-8290.22540340.v1
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7
Supplementary Figure from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets
Autor: Olaf Witt, Stefan M. Pfister, David Capper, Jan J. Molenaar, David T.W. Jones, Annette Kopp-Schneider, Peter Lichter, Ruth Witt, Angelika Freitag, Uta Dirksen, Andreas von Deimling, Felix Sahm, David Reuss, Stephan Wolf, Natalie Jäger, Till Milde, C. Michel Zwaan, Bianca Goemans, Maria Filippidou, Antonis Kattamis, Bernarda Kazanowska, Olli Lohi, Nicolas U. Gerber, Caroline Hutter, Ingrid Øra, Roman Tremmel, Matthias Schwab, Simone Hettmer, Monika Scheer, Michael T. Meister, Ewa Koscielniak, Simone Fulda, Petra Ketteler, Ines B. Brecht, Dominik T. Schneider, Michael C. Frühwald, Stefanie Hecker-Nolting, Michaela Nathrath, Wilhelm Wößmann, Birgit Burkhardt, Angelika Eggert, Matthias Fischer, Frank Westermann, Norbert Graf, Peter Vorwerk, Gabriele Calaminus, André O. von Bueren, Christof M. Kramm, Irene Schmid, Dietrich von Schweinitz, Stephan Tippelt, Gudrun Fleischhack, Jan-Henning Klusmann, Dirk Reinhardt, Roland Meisel, Arndt Borkhardt, Andrej Lissat, Andreas E. Kulozik, Arend von Stackelberg, Kerstin Grund, Christian Sutter, Steffen Hirsch, Nicola Dikow, Kathrin Schramm, Mirjam Blattner-Johnson, Pascal D. Johann, Sebastian Stark, Gnana Prakash Balasubramanian, Barbara C. Jones, Petra Fiesel, Karin P.S. Langenberg, Kristian W. Pajtler, Elke Pfaff, Cornelis M. van Tilburg
Supplementary Figure from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87241d6487fda7eea0b9f69782d2a059
https://doi.org/10.1158/2159-8290.22540361.v1
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8
Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma
Autor: Jeff DeMartino, Michael T. Meister, Lindy Visser, Mariël Brok, Marian J. A. Groot Koerkamp, Laura S. Hiemcke-Jiwa, Terezinha de Souza, Johannes H. M. Merks, Frank C. P. Holstege, Thanasis Margaritis, Jarno Drost
Publikováno v: bioRxiv
BioRxiv
Paediatric rhabdomyosarcoma (RMS) is a soft tissue malignancy of mesenchymal origin which is thought to arise as a consequence of derailed myogenic differentiation. Despite intensive treatment regimens, the prognosis for high-risk patients remains di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8bb156f85717f807999957a119c863
https://doi.org/10.1101/2022.07.15.497944
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