Výsledky vyhledávání - "Michael T, Dellinger"

Akademický článek

Meeting Report for the 2023 International Scientific Conference on Complex Lymphatic Anomalies

Autor: Michael T. Dellinger, Tiffany Ferry, David Williams, Tracy Milne, Louise Murgia, Michael Kelly

Publikováno v: Journal of Vascular Anomalies, Vol 5, Iss 2, p e085 (2024)

Objectives:. Complex lymphatic anomalies (CLAs) are rare diseases with variable clinical manifestations caused by the abnormal development of lymphatic vessels. The Lymphatic Malformation Institute (LMI), Lymphangiomatosis & Gorham’s Disease Allian

Externí odkaz: https://doaj.org/article/137975c3d167419d8f39c58a234f2111

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Akademický článek

Trametinib Inhibits Lymphatic Vessel Invasion of Bone in a Mouse Model of Gorham-Stout Disease

Autor: Anna L. McCarter, Michael T. Dellinger

Publikováno v: Journal of Vascular Anomalies, Vol 4, Iss 4, p e070 (2023)

Objective:. Gorham-Stout disease (GSD) is a rare lymphatic anomaly that can be caused by somatic activating mutations in KRAS. This discovery has led investigators to suggest that MEK inhibitors could be a novel treatment for GSD. However, the effect

Externí odkaz: https://doaj.org/article/628977654a84472b8067c0b9c3330262

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Akademický článek

Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function

Autor: Lorenzo M. Fernandes, Jeffrey Tresemer, Jing Zhang, Jonathan J. Rios, Joshua P. Scallan, Michael T. Dellinger

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Complex lymphatic anomalies (CLAs) are sporadically occurring diseases caused by the maldevelopment of lymphatic vessels. We and others recently reported that somatic activating mutations in KRAS can cause CLAs. However, the mechanisms by which activ

Externí odkaz: https://doaj.org/article/ba2b069fed614929b94de62055977d42

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Akademický článek

KRAS-driven model of Gorham-Stout disease effectively treated with trametinib

Autor: Nassim Homayun-Sepehr, Anna L. McCarter, Raphaël Helaers, Christine Galant, Laurence M. Boon, Pascal Brouillard, Miikka Vikkula, Michael T. Dellinger

Publikováno v: JCI Insight, Vol 6, Iss 15 (2021)

Gorham-Stout disease (GSD) is a sporadically occurring lymphatic disorder. Patients with GSD develop ectopic lymphatics in bone, gradually lose bone, and can have life-threatening complications, such as chylothorax. The etiology of GSD is poorly unde

Externí odkaz: https://doaj.org/article/daf96aceec344bbdab8af7aa33bd468c

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Akademický článek

The emergence of targetable MEKanisms in sporadic lymphatic disorders

Autor: Michael T Dellinger, Francis X McCormack

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 10, Pp 1-3 (2020)

Abstract Sporadic lymphatic diseases are orphans among orphans in the medical community, a diverse collection of disorders at the intersection of cardiac, gastrointestinal, pulmonary, dermatologic, and oncologic disease that receives only passing att

Externí odkaz: https://doaj.org/article/5f8356fd1eee46688c5f887a7456ceac

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