Early transcriptional responses in mouse embryos as a basis for selection of molecular markers predictive of valproic acid teratogenicity

Autor: Lennart Dencker, Måns Jergil, Kim Kultima, Hugh Salter, Anne-Lee Gustafson, Michael Stigson

Publikováno v: Reproductive Toxicology. 30:457-468

Cell-based in vitro assays would potentially reduce animal testing in preclinical drug development. Mouse embryos exposed to the teratogenic drug valproic acid (VPA) in utero for 1.5, 3 or 6h on gestational day 8 were analyzed using microarrays. Sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6f2bf5ffe833709e014009c3cfcc76
https://doi.org/10.1016/j.reprotox.2010.05.014

Cadmium-induced gene expression changes in the mouse embryo, and the influence of pretreatment with zinc

Autor: Anne-Lee Gustafson, Lennart Dencker, Birger Scholz, Michael Stigson, Kim Kultima, Estíbaliz L. Fernández

Publikováno v: Reproductive Toxicology. 22:636-646

Cadmium (Cd) administered to female C57BL/6 mice on gestation day 8 induces a high incidence of anterior neural tube defects (exencephaly). This adverse effect can be attenuated by maternal pretreatment with zinc (Zn). In this study we used replicate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41813e2841434a141c247f6113d2e6e
https://doi.org/10.1016/j.reprotox.2006.05.007

Valproic Acid Teratogenicity: A Toxicogenomics Approach

Autor: Michael Stigson, Birger Scholz, Lennart Dencker, Kim Kultima, Anna-Maja Nyström, Anne-Lee Gustafson

Publikováno v: Environmental Health Perspectives

Embryonic development is a highly coordinated set of processes that depend on hierarchies of signaling and gene regulatory networks, and the disruption of such networks may underlie many cases of chemically induced birth defects. The antiepileptic dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd915097aec1c5ba5c203a6a8abec28
http://europepmc.org/articles/PMC1277116

PG-M/Versican-like Proteoglycans Are Components of Large Disulfide-stabilized Complexes in the Axolotl Embryo

Autor: Michael Stigson, Jan Löfberg, Lena Kjellén

Publikováno v: Journal of Biological Chemistry. 272:3246-3253

Large disulfide-stabilized proteoglycan complexes were previously shown to be synthesized by the epidermis of axolotl embryos during stages crucial to subepidermal migration of neural crest cells. We now show that the complexes contain PG-M/versican-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc25650fe606add3e08396090643ac8
https://doi.org/10.1074/jbc.272.6.3246

Exposure to brominated flame retardant PBDE-99 affects cytoskeletal protein expression in the neonatal mouse cerebral cortex

Autor: Lennart Dencker, Michael Stigson, Per E. Andrén, Anna Nilsson, Kim Kultima, Birger Scholz, Asa Fex-Svenningsen, Henrik Alm

Publikováno v: Alm, H, Kultima, K, Scholz, B, Nilsson, A, Andrén, P E, Svenningsen, Å F, Dencker, L & Stigson, M 2008, ' Exposure to brominated flame retardant PBDE-99 affects cytoskeletal protein expression in the neonatal mouse cerebral cortex ', NeuroToxicology, vol. 29, no. 4, pp. 628-37 . https://doi.org/10.1016/j.neuro.2008.04.021

Polybrominated diphenyl ethers (PBDEs) are environmental contaminants found in human and animal tissues worldwide. Neonatal exposure to the flame retardant 2,2', 4,4',5-pentabromodiphenyl ether (PBDE-99) disrupts normal brain development in mice, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c62225fcaeeb21af3ff916056d4338
https://pubmed.ncbi.nlm.nih.gov/18550172